- Docente: Francesco Novello Paglianti
- Credits: 5
- SSD: MED/04
- Language: Italian
- Moduli: Francesco Novello Paglianti (Modulo 1) Annalisa Pession (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Second cycle degree programme (LS) in Biological and Health Sciences (cod. 0441)
Learning outcomes
The aim of the course is to give advanced information about
pathological mechanisms, genetics of pathology and genetic analysis
of tumors in animal models.
Course contents
organ and system pathology: heart diseases, respiratory
diseases,
kidney diseases, circulatory diseases, alterations of saline
balance, red cells diseases.
oncology: oncogenes and oncosuppressors, hereditary cancers:
brca
and breast cancer, colon cancer and satellite instability,
oligodendrogliomas and loh analysis, medullary thyroid
carcinomas
and ret mutations.
genetics: most frequent mutations in mendelian diseases,
genotype/phenotype correlation, main mutation analysis
techniques:
familiar hypercholesterolemia, sickle cells anemia, cystic
fibrosis, x-fragile syndrome. genetic imprinting.
Animal models:
Mouse: transgenic mice, conditional and inducible KO, orthotopic
models. ici. Modelling of pediatric tumours: retinoblastoma,
medulloblastoma and neuroblastoma.
Drosophila: transgenesis and binary genetic
systems. Study of oncogenes and tumour
suppressors.
Readings/Bibliography
Pontieri Russo Frati, Patologia generale ( IIIed) vol.II. Piccin
ed
Robbins, Basi Patologiche delle Malattie
Harrison's, Principles of internal medicine McGraw-Hill
eds
Teaching methods
Oral lectures.
Assessment methods
Oral exam.
Teaching tools
Trasparencies and power point presentations.
Office hours
See the website of Francesco Novello Paglianti
See the website of Annalisa Pession