- Docente: Pier Giorgio Cozzi
- Credits: 3
- SSD: CHIM/06
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LS) in Industrial Molecular Biotechnologies (cod. 0444)
Learning outcomes
The combinatorial chemistry is the Science of molecular diversity and rational screening.
Course contents
Synthesis of combinatorial libraries using portioning-mixing procedure. One bead-one compound combinatorial library method. Synthesis and screening of positional scanning synthetic combinatorial libraries. Highthroughput combinatorial synthesis of discrete compounds: non-chemical encoding and direct sorting. Positional addressable parallel synthesis. Resins and anchors for solid phase organic synthesis. Organic reactions on solid support: an overview. Analytical methods in combinatorial chemistry. Multicomponents reactions for chemical libraries: Biginelli, Passerini and Ugi.Combinatorial methods for materials discovery. Combinatorial methods for discovery of biologically active compounds.
Readings/Bibliography
Combinatorial chemistry, a practical approach,
Hicham Fenniri Ed.
Teaching methods
Lessons and practical synthesis of combinatorial library using a combichem apparatus.
Assessment methods
Discussion, comments and analysis of a recent article of combinatorial chemistry concerned a biological problem.
Teaching tools
Photocopies, overheads and other materials taken from original articles. Note from the professors.
Office hours
See the website of Pier Giorgio Cozzi