New synthetic process of phenolic derivatives

"Green" procedure for obtaining phenol derivatives of high industrial interest using glycerol carbonate.

Title of the patent Process for obtaining phenolic derivatives through the use of glycerol carbonate
Thematic area Chemistry and biotechnology
Ownership Alma Mater Studiorum – Università di Bologna
Inventors Fabrizio Cavani, Tommaso Tabanelli, Carlo Giliberti
Protection International
Licensing status Available for licensing agreement
Keywords Phenol, catechol, glycerol carbonate, cyclization reaction, base catalysed reactions
Filed on Mar 23, 2017

Organic carbonates are among the most promising green candidates for the replacement of conventional harmful solvents and reagents for the development of innovative intermediates in the pharmaceutical, lubricants and polymers sectors. In particular, they are the most environmentally friendly alternative for carbonylation and alkylation reactions.

Synthesis of phenolic derivatives through the alkylation and consecutive intramolecular cyclization reaction of catechol and glycerol carbonate.

• very good yield

• innovative and ecological process

• glycerol carbonate is a safe, non-toxic and environmentally friendly compound

• higher selectivity

• the reaction does not require any reaction solvent or halogenated compound