Modified calcium silicate-containing adhesive systems

A bioactive/therapeutic bonding agent containing modified calcium-silicate cements preserving the longevity of resin dentine bonds.

Title of the patent Dental Adhesive SystemS
Thematic area Chemistry and biotechnology
Ownership Alma Mater Studiorum - Università di Bologna and King’s College London
Inventors Giovanni Valdrè, Romano Mongiorgi, Boris De Carlo, Salvatore Sauro, Timothy Watson, Francesco Mannocci
Protection International application
Licensing status Available for licensing agreement
Keywords Calcium silicate, Portland, smectite, hydrotalcite, titanium oxide, bioactive filler
Filed on Oct 20, 2011

Simplified etch-and-rinse and/or self-etch adhesive systems currently used in conservative/restorative dentistry are affected by reduced longevity due to the degradation of the hybrid layer.

The hybrid layer degradation is mainly due to the incapability of these bonding systems to completely replace the water from the extra-fibrillar and intra-fibrillar collagen compartments with resin monomers.

Moreover, these resin monomers within the hybrid layer are affected by hydrolytic degradation when exposed to fluids. 

A bioactive/therapeutic bonding agent containing modified calcium-silicate cements may accomplish this aim by replacing water from resin-sparse regions of the hybrid layer with apatite crystallites that are small enough to occupy the extrafibrillar and intrafibrillar compartments of the collagen matrix and restoring the enzyme exclusion and fossilization properties of mineralized dentine preserving the longevity of resin dentine bonds.

  • The adhesive systems may retain their bond strength for a longer period of time relative to known adhesive systems;
  • The bond strength does not degrade as quickly due to remineralisation/protection of the hybrid layer;
  • Some of the adhesive systems may also provide increased bond strength;
  • Calcium-silicate cements demonstrate a wide range of clinical applications including root-end filling material, root perforation repair, pulp capping and dentine hypersensitivity.