91404 - Forensic Molecular Biology

Learning outcomes

At the end of the course, students will acquire theoretical and methodological knowledge about the main applications of molecular biology in forensic sciences. In particular, students will learn and apply molecular methods (based on DNA, RNA, protein analysis) for the identification of biological specimens, for personal identification and ancestry reconstruction, for parentage testing, and for the prediction of physical characteristics (such as eye, hair and skin color, craniofacial morphology, etc.). Students will also acquire practical skills on the main statistical and bioinformatical methods of data analysis.

Course contents

The course contents will be organized according to the following topics:

• Human genetic variability
• Analysis of biological samples from different specimens
  
• Molecular anthropology techniques for the analysis of genetic markers and DNA polymorphisms (mtDNA, Y and X, autosomal DNA)
• Statistical methods in genetic and forensic analysis
  
• DNA databases used in forensic and population genetic fields
• Personal identification and reconstruction of biogeographical ancestry
• Genetic genealogies in the genomic era
• Prediction of phenotypic traits based on genetic data
• Application of human epigenetic variability in forensics

Readings/Bibliography

The slides of the lecturers will be provided during the course. Additional readings from the following book: “Forensic DNA Applications: An Interdisciplinary Perspective” (2014), Edited by Dragan Primorac and Moses Schanfield. CRC Press, Taylor Francis Group.

Teaching methods

The course consists of two parts:

Module1: lectures (3 CFU, 24 hours)

Module2: lectures (1 CFU, 8 hours), in-silico exercises (1 CFU, 10 hours), laboratory activities (1 CFU, 12 hours).

 

According to this typology of activities, in order to follow such a course the students should have attended Module 1 and 2 (e-learning) and Module 3 for specific training on safety and health at study locations.

Information about Module 1 and 2 are available at: https://www.unibo.it/it/servizi-e-opportunita/salute-e-assistenza/salute-e-sicurezza/sicurezza-e-salute-nei-luoghi-di-studio-e-tirocinio

Information about dates and modes of Module 3 are available at the web page of the Second Cycle Degree in Biodiversity and Evolution.

Assessment methods

Written test including a combination of multiple-choice and open questions, and based on all topics covered during the course.

Teaching tools

PDF slides of the course, computer exercises and laboratory activities.

Office hours

See the website of Stefania Sarno

See the website of Cristina Giuliani