Foto del docente

Stefania Trazzi

Junior assistant professor (fixed-term)

Department of Biomedical and Neuromotor Sciences

Academic discipline: BIO/09 Physiology

Publications

Fuchs C.; Medici G.; Trazzi S.; Gennaccaro L.; Galvani G.; Berteotti C.; Ren E.; Loi M.; Ciani E., CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling, «BRAIN PATHOLOGY», 2019, 29, pp. 1 - 17 [Scientific article]

Ren E.; Roncace V.; Trazzi S.; Fuchs C.; Medici G.; Gennaccaro L.; Loi M.; Galvani G.; Ye K.; Rimondini R.; Aicardi G.; Ciani E., Functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are rescued by a TrkB agonist, «FRONTIERS IN CELLULAR NEUROSCIENCE», 2019, 13, pp. 1 - 15 [Scientific article]

Trazzi, Stefania; De Franceschi, Marianna; Fuchs, Claudia; Bastianini, Stefano; Viggiano, Rocchina; Lupori, Leonardo; Mazziotti, Raffaele; Medici, Giorgio; Martire, Viviana Lo; Ren, Elisa; Rimondini, Roberto; Zoccoli, Giovanna; Bartesaghi, Renata; Pizzorusso, Tommaso; Ciani, Elisabetta*, CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder, «HUMAN MOLECULAR GENETICS», 2018, 27, pp. 1572 - 1592 [Scientific article]

Fuchs, Claudia; Gennaccaro, Laura; Trazzi, Stefania; Bastianini, Stefano; Bettini, Simone; Martire, Viviana Lo; Ren, Elisa; Medici, Giorgio; Zoccoli, Giovanna; Rimondini, Roberto; Ciani, Elisabetta*, Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder, «NEURAL PLASTICITY», 2018, 2018, pp. 1 - 18 [Scientific article]

Fuchs, Claudia; Fustini, Norma; Trazzi, Stefania; Gennaccaro, Laura; Rimondini, Roberto; Ciani, Elisabetta*, Treatment with the GSK3-beta inhibitor Tideglusib improves hippocampal development and memory performance in juvenile, but not adult, Cdkl5 knockout mice, «EUROPEAN JOURNAL OF NEUROSCIENCE», 2018, 47, pp. 1054 - 1066 [Scientific article]

Guidi, Sandra; Bianchi, Patrizia; Stagni, Fiorenza; Giacomini, Andrea; Emili, Marco; Trazzi, Stefania; Ciani, Elisabetta; Bartesaghi, Renata, Lithium Restores Age Related Olfactory Impairment in the Ts65Dn Mouse Model of Down Syndrome, «CNS & NEUROLOGICAL DISORDERS. DRUG TARGETS», 2017, 16, pp. 812 - 819 [Scientific article]

Trazzi, Stefania; Fuchs, Claudia; Viggiano, Rocchina; De Franceschi, Marianna; Valli, Emanuele; Jedynak, Paulina; Hansen, Finn K; Perini, Giovanni; Rimondini, Roberto; Kurz, Thomas; Bartesaghi, Renata; Ciani, Elisabetta, HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder, «HUMAN MOLECULAR GENETICS», 2016, 25(18), pp. 3887 - 3907 [Scientific article]

Stagni, F; Giacomini, A; Emili, M; Trazzi, S; Guidi, S; Sassi, M; Ciani, E; Rimondini, R; Bartesaghi, R, Short- and long-term effects of neonatal pharmacotherapy with epigallocatechin-3-gallate on hippocampal development in the Ts65Dn mouse model of Down syndrome, «NEUROSCIENCE», 2016, 333, pp. 277 - 301 [Scientific article]

Giacomini, Andrea; Stagni, Fiorenza; Trazzi, Stefania; Guidi, Sandra; Emili, Marco; Brigham, Elizabeth; Ciani, Elisabetta; Bartesaghi, Renata, Inhibition of APP gamma-secretase restores Sonic Hedgehog signaling and neurogenesis in the Ts65Dn mouse model of Down syndrome, «NEUROBIOLOGY OF DISEASE», 2015, 82, pp. 385 - 396 [Scientific article]

Fuchs, C.; Rimondini, R.; Viggiano, R.; Trazzi, S.; De Franceschi, M.; Bartesaghi, R.; Ciani, E., Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder, «NEUROBIOLOGY OF DISEASE», 2015, 82, pp. 298 - 310 [Scientific article]

Trazzi S;Fuchs C;De Franceschi M;Mitrugno VM;Bartesaghi R;Ciani E, APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome., «NEUROBIOLOGY OF DISEASE», 2014, 67, pp. 24 - 36 [Scientific article]

Bianchi P; Bettini S; Guidi S; Ciani E; Trazzi S; Stagni F; Ragazzi E; Franceschini V; Bartesaghi R., Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome, «EXPERIMENTAL NEUROLOGY», 2014, 251, pp. 1 - 11 [Scientific article]

Fuchs C;Trazzi S;Torricella R;Viggiano R;De Franceschi M;Amendola E;Gross C;Calzà L;Bartesaghi R;Ciani E, Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling., «NEUROBIOLOGY OF DISEASE», 2014, 70, pp. 53 - 68 [Scientific article]

Sandra Guidi;Fiorenza Stagni;Patrizia Bianchi;Elisabetta Ciani;Elena Ragazzi;Stefania Trazzi;Gabriele Grossi;Chiara Mangano;Laura Calzà;Renata Bartesaghi, Early Pharmacotherapy with Fluoxetine Rescues Dendritic Pathology in the Ts65Dn Mouse Model of Down Syndrome, «BRAIN PATHOLOGY», 2013, 23, pp. 129 - 143 [Scientific article]

Trazzi S; Fuchs C; Valli E; Perini G; Bartesaghi R; Ciani E., The amyloid precursor protein (APP) triplicated gene impairs neuronal precursor differentiation and neurite development through two different domains in the Ts65Dn mouse model for down syndrome., «THE JOURNAL OF BIOLOGICAL CHEMISTRY», 2013, 288, pp. 20817 - 20829 [Scientific article]

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