- Docente: Paola Fantazzini
- Credits: 6
- SSD: FIS/07
- Language: Italian
- Moduli: Paola Fantazzini (Modulo 1) Leonardo Brizi (Modulo 2)
- Teaching Mode: Traditional lectures (Modulo 1) Traditional lectures (Modulo 2)
- Campus: Bologna
- Corso: Second cycle degree programme (LM) in Physics (cod. 8025)
Learning outcomes
At the end of the course, the student will know a critical knowledge of important physical experimental procedures applied to medicine, including advanced techniques for diagnosis, for functional analysis and for radiotherapy. The student will have the possibility to use software for simulation of NMR experiments and for data inversion.
Course contents
Physical basis of Nuclear Magnetic Resonance (NMR) - Time Domain NMR (TD-NMR). Relaxometry - Relaxation times and molecular motion. Blembergen, Purcell, Pound theory- Surface effects - Relaxation times in biological tissues - Inversion from data time domain to relaxation times - UPEN algorithm and UpenWin software - Ex situ analyses. Imaging (MRI) spin-warp method - k-space and k-space mapping- PERFIDI filters. Chemical Shift Imaging. Molecular Diffusion Imaging. Fiber Tractography. Functional MRI.
X rays- X rays production - Interactions photons-matter. CT scanners - photon energy for medical CT- beam hardening. Hounsfielf units - Applications.
SPECT – PET- physical basis- Applications.
Radiotherapy – LINAC - Adrotherapy. Bragg peak- Applications.
Ultrasounds in medicine
Readings/Bibliography
Callaghan, Principles of MRMicroscopy e sito online di Hornak;
R. Zannoli e C. Orsi, Elementi di Strumentazione Medica, Società Editoriale Esculapio (1999)
M. Marengo, La Fisica in Medicina Nucleare, Patron Editore, Bologna, (2006)
Teaching methods
classroom lessons
Assessment methods
Oral examination, after discussion of scientific reports on data analysis, based on the application of dedicated algoritms and softwares elucidated during the lectures.
Teaching tools
use of softwares for data simulations and data inversion (2 CFU)
Office hours
See the website of Paola Fantazzini
See the website of Leonardo Brizi