00061 - Biochemistry

Learning outcomes

The course aims to provide the students of the basic knowledge of biochemistry and molecular biology. Information at the molecular level regarding the structure and function of the biological molecules will be presented as tools to understand the main methabolic pathways, the mechanism of action of drugs and the molecular mechanisms involved with deseases development.

Course contents

1. Basic measure Units.

2. Water structure and the concept of pH

3. The major chemical bonds of biological molecules
4.Proteins structure and function
a) The aminoacids, their structure and the peptidic bond
b) Primary structure of proteinsS
c) Secondary structure of proteins.
d) Tertiary structure of proteins.
e) Proteins' folding and the "Anfinsen cage".
f) Quaternary structure of proteins: From Mioglobin to 
Hemoglobin.
5. Molecular Biology
6. Enzymology
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"First part of the test"

7. The sugars
8. The lipids
9. The enzime cofactors
10. Bioenergetics and the Methabolism.
11. The glycolisis and the related pathways for glucose availability and degradation.
12. The Citric acid cycle.
13. The oxydative phosphorylation-
14. The lipids methabolism.
15. The amino acids methabolism and the urea cycle.

Readings/Bibliography

FONDAMENTI DI BIOCHIMICA di D. Voet, J. Voet e C. Pratt, edizioni Zanuchelli

BIOCHIMICA di L. Stryer, 4a edizione, ed. Zanichelli 

PRINCIPI DI BIOCHIMICA di A. Lehninger et al., 2a edizione, ed. Zanichelli.

All the quoted books are available for consultation at the "Biblioteca della Università di Bologna-sede di Rimini"  in Via Angherà 22.

Teaching methods

Lectures are based on Power Points projections

Assessment methods

The final test is oral. An "in itinere" intermediate exam (see the Program) is possible for all those students that will register for it.

Teaching tools

PDF presentations are stored  in AMS Campus (servizi online "Materiale didattico).

Office hours

See the website of Paolo Neyroz