23276 - General Pathology and Immunology

Learning outcomes

At the end of the course, students will be able to understand the causes and pathogenic mechanisms of human diseases, and the etiology of structures, functions and control mechanisms alterations at several levels of integration. The students will learn the principles and biological basis of immune response regulation, including the pathophysiology of immune response impairement in major diseases.

Course contents

Module 1

MECHANISMS OF DISEASES

Cell injury and adaptation. Cell death. Stem cells

ENVIRONMENTAL AND NUTRITIONAL DISEASES Diseased caused by chemical or physical agents; nutritional disorders and obesity.

ONCOLOGY

The neoplastic cell; tumor classification; carcinogenesis; epidemiology and prevention; molecular genetics of cancer, oncogenes and tumor suppressor genes; tumor progression; metastasis.

HEREDITARY DISEASES

Genetic diseases: autosomal dominant and recessive disorders, X-linked disorders, chromosomal disorders. Familial tumors. Multifactorial disorders (Alzheimer’s disease).

 

Module 2

Cellular pathology: the damage, DAMPS; PAMPS, MAMPS;

Inflammatory-reparative response: etiology and classification of acute inflammation, chemical mediators, vascular changes and exudate formation, cellular events and phagocytosis, systemic consequences and etiopathogenesis of fever; chronic and granulomatous inflammation, pathogenesis of tuberculosis; adult stem cells, reparative response: tissue repair and wound healing, fibrosis.

Immunology: cells and tissues of the immune system; innate and specific immunity; antigens; major histocompatibility complex; antigen processing and presentation; humoral and cell-mediated immune responses; antibody; complement; tolerance.

Immunopathology: Hypersensitivity Autoimmunity. Immunodeficiency syndrome. Graft rejection.

General physiopathology: hemostasis and hemorrhagic diseases; risk factors of atherosclerosis, formation of atheromatous plaque and related consequences; thrombosis; embolism; infarction; hypoxia and cyanosis; oedema.

Readings/Bibliography

Teaching slides are recommended (available on line on virtuale.unibo.it website).

REFERENCE BOOK LIST

1. Le basi della patologia generale di Sunil R. Lakhani. Ed. Zanichelli (recommended)
   
2. J.A.M. Maier – “Patologia generale e fisiopatologia per le professioni sanitarie” II edizione – Mc Graw Hill Editore
3. Patologia Generale e Fisiopatologia Generale
   F. MAINIERO et al. 2018/2019. Ed. Piccin

Teaching methods

Lectures (36 hours). 

Assessment methods

Student learning will be checked at the end of the course through a test. The overall knowledge in immunology, pathology and general physiopathology will be assessed using multiple-choice questions.

Teaching tools

Teaching slides will be available on line at Unibo e-learning website https://virtuale.unibo.it

Links to further information

http://corsi.unibo.it/InfermieristicaBologna/Pagine/default.aspx

Office hours

See the website of Manuela Ferracin

See the website of Massimiliano Bonafè