07732 - Clinical Pathology

Academic Year 2022/2023

  • Teaching Mode: Blended Learning
  • Campus: Ravenna
  • Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 5708)

Learning outcomes

To allow the students to acquire the fundamental notions for a critical evaluation and interpretation of the results of the main clinical laboratory tests. In particular, the student will learn to recognize and discuss the clinical meaning of laboratory data which characterize the following pathological conditions: acute and chronic inflammations; coagulation disorders; lipid disorders; hepatic disorders, renal disorders; diabetes.

Course contents

- Complete blood count with leukocyte formula.

- The laboratory in the evaluation of the haemostatic function. Laboratory investigations for the evaluation of platelet function, the plasma phase of coagulation and the fibrinolytic system; laboratory investigations for the definition of hypercoagulability states.

- Anemias. Laboratory classification. Microcytic, normocytic and megaloblastic anemias.

- Serum proteins. Electrophoretic separation of serum proteins; electrophoretic profiles associated with specific pathologies; acute phase proteins and erythrocyte sedimentation rate (ESR).


- Laboratory diagnosis of dyslipoproteinemias. Lipoproteins and atherosclerosis; quantitative and qualitative evaluation of the lipoprotein structure.

- The laboratory in the diagnostic evaluation of diabetes. Diabetes classification; metabolic changes in diabetes; laboratory tests for the diagnosis of diabetes and for the control of the diabetic patient.

- First level laboratory tests for the study of liver function. Bilirubin and urobilinogen; serum enzymes indicators of cytolysis and cholestasis, albumin / globulin ratio; clotting factors.

- Laboratory tests for the study of renal functions. Urinalysis (chemical, physical and sediment); determination of the blood concentration of non-protein nitrogen compounds (creatininemia).

- Clinical and laboratory correlation (blood and urine tests, histopathological data) between hematopoietic dyscrasias and renal disease (5 experimental hours).

Readings/Bibliography

- Marcello Ciaccio e Giuseppe Lippi: Biochimica Clinica e Medicina di Laboratorio. Terza edizione, 2020 EdiSES Università S.r.l. - Napoli.

- Italo Antonozzi e Elio Gulletta: Medicina di Laboratorio: Logica & Patologia Clinica. Terza edizione, 2019 Piccin Nuova Libraria S.p.A. Padova.

Teaching methods

The course consists of 2 CFU, corresponding to 16 hours. Of these 5 hours will be conducted according to an experimental model in which students will independently follow a path aimed at understanding the importance that laboratory tests have in identifying the effects that some haematological diseases may have on renal function.

Assessment methods

The exam will be held jointly with the Colleagues of Clinical Microbiology and Clinical Biochemistry. Each candidate will be asked three questions on topics from the three disciplines selected by the commission. The final mark will correspond to the average of the marks obtained in the individual tests.

Teaching tools

The slides shown during the lessons are available at the Web site: https://virtuale.unibo.it/ Username e password are reserved to students of Bologna University.

Office hours

See the website of Gianandrea Pasquinelli

SDGs

Good health and well-being Quality education

This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.