03766 - Immunology (AK-A)

Academic Year 2022/2023

  • Teaching Mode: Traditional lectures
  • Campus: Bologna
  • Corso: Single cycle degree programme (LMCU) in Medicine and Surgery (cod. 8415)

Course contents

Immunology for Medical School

Introduction to the Immune System (IS): functions and features of IS; innate and acquired immunity; cells of the IS: lymphocytes, macrophages, granulocytes, dendritic cells, etc. Primary and secondary response.

Organs and tissues of the IS: generative and secondary organs (bone marrow, thymus, lymph nodes, spleen, SI associated to the mucoses). Lymphatic System and lymphocyte recirculation. 

Innate Immunity: physical barriers, preformed proteins, professional phagocytes, NK and NKT cels, gamma-delta lymphocytes. Mechanisms of phagocytosis and killing of pathogens. Role and receptors of NK cells (NKC and LRC). Mechanisms of antigen recognition of Innate Immunity (TLR, RIG, NLR and inflammasome). The memory of Innate Immunity: the trained immunity.

Specific Immunity: features and functions, antigen receptors of cells of the specific immunity (membrane-linked antibodies and TCR), antigen recognition; creation of the receptor repertoire, somatic recombination, clonal distribution. MHC molecules, antigen processing and presentation; proteasome and immunoproteasome. Dendritic cells.

B Lymphocytes: features, development, maturation and activation; structure of B cell receptor. Functions in the Immune response: secreted antibodies: structure, functions, classification. Monoclonal antibodies in diagnostics and therapies.

T lymphocytes: features of T helper (CD4+) and cytotoxic (CD8+), development, maturation and activation; structure of T cell receptor. Functions in the Immune response: cell-mediated immunity. Production of cytokines, Th1 and Th2 lymphocytes, natural and induced Treg. Cytotoxicity. Regional immunity: the intestinal mucoses. Relationships with the gut microbiota. Th17 lymphocytes. Engineered T cells: CAR-T cells.

T-B Cooperation; costimulation: role of accessorial molecules; T-dependent and independent responses; isotypic switch; suppression of T cell response. Cytokines and cytokine receptors. Th1 and Th2 responses.

Tolerance: recognition and discrimination between self and non-self. Mechanisms of central and peripheral tolerance (anergy, deletion and suppression).

Effective phase of the Immune Response. Complement; activation of macrophages M1 and M2; delayed type hypersensitivity; Cytotoxic T lymphocytes activation;

 

Immunopathology (hypersensitivity and immunodeficiencies), response to pathogens, vaccinology, and transplant immunology: for this part of the program, please refer to the web page of the module (AK-b) held by Dr. Miriam Capri.

 

Readings/Bibliography

Abbas, Lichtman, Pillai: Immunologia Cellulare e Molecolare,2022 (decima edizione), Piccin Libraria.

Dianzani e Puccillo (a cura di): Immunologia e Immunopatologia, Edi-Ermes, 2022

Geha, Notarangelo: Casi Studio in Immunologia, 2019 (settima edizione), Piccin.

Teaching methods

frontal lectures with ppt slides

Assessment methods

Students will have access to the exam if they have attended at least 66% of the lectures.

The learning assessment is in written form and consists of two parts:

- the first part consists of two free-answer questions on themes of the Course. Every question can contribute to the final mark with 10 points out of 30. Insufficient answer (<6 out of 10) to one of these questions leads to test failure with no further evaluation of the second part.

- the second part consists of 40 quiz of the type "true-or-false" on themes of the Course. Every correct answer contributes with 3/10 points, every wrong answer leads to a penalty of -1/10. The total points available for this parts are 12.

Further information on exam evaluation can be be required during the first lesson of the Course.

Warning: in case of Covid-19 pandemic reactivation, it is possible that exams and lectures will be required to be done in remote. In this case,  exams will be given online with the Microsoft Teams platform in oral form. Students must register as usual in Almaesami, and they will receive an e-mail with the link and timetable of the exam session.

In case of changes of exam modes, students will be promptly notified, both during lectures and on Almaesami website.

The aim of the oral exam is to evaluate the knowledge of the student on the course's topics and the capability to perform logical connections.

Grading procedure:

- knowledge of a very limited number of topics and limited analytical capacity → 18-19 out of 30;

- knowledge of a limited number of topics and basic analytical capacity → 20-24 out of 30;

- knowledge of a consistent number of topics and good analytical capacity → 25-29 out of 30;

- knowledge of all topics and very good analytical capacity → 30-30L out of 30.

Attention: a single exam mark will be registered for the Integrated Course by averaging the two marks of Immunology and Molecular Pathology. 

The Responsible for the Integrated Course is in charge for the registration of the final mark. A number of calls for the Immunology Exam will be created on Almaesami JUST FOR THE REGISTRATION OF THE FINAL MARK. Students who have the marks for both Immunology and Molecular Pathology are required to enroll in one of these calls. Upon enrollment, the Responsible of the Integrated Course will proceed with the registration of the final mark. Presence is not required.

It is strongly suggested to obtain the marks for the two parts of the Integrated Course (immunology and Molecular Pathology) within one year.

Teaching tools

power point files available at https://virtuale.unibo.it/course/view.php?id=16951

Office hours

See the website of Stefano Salvioli

SDGs

Good health and well-being

This teaching activity contributes to the achievement of the Sustainable Development Goals of the UN 2030 Agenda.