Foto del docente

Giuseppina Di Stefano

Associate Professor

Department of Medical and Surgical Sciences

Academic discipline: MED/04 Experimental Medicine and Pathophysiology


Iacovino L.G.; Rossi M.; Di Stefano G.; Rossi V.; Binda C.; Brigotti M.; Tomaselli F.; Pasti A.P.; Dal Piaz F.; Cerini S.; Hochkoeppler A., Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme, «BIOCHIMIE», 2022, 199, pp. 23 - 35 [Scientific article]

Pasti A.P.; Rossi V.; Di Stefano G.; Brigotti M.; Hochkoeppler A., Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme, «BIOSCIENCE REPORTS», 2022, 42, Article number: BSR20212654 , pp. 1 - 19 [Scientific article]Open Access

Rossi V.; Govoni M.; Farabegoli F.; Di Stefano G., Lactate is a potential promoter of tamoxifen resistance in MCF7 cells, «BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS», 2022, 1866, Article number: 130185 , pp. 130185 - N/A [Scientific article]

Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea, The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2022, 23, Article number: 8338 , pp. 1 - 14 [Scientific article]Open Access

Balboni A.; Govoni M.; Rossi V.; Roberti M.; Cavalli A.; Di Stefano G.; Manerba M., Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment, «BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS», 2021, 1865, Article number: 129760 , pp. 1 - 10 [Scientific article]

Govoni M.; Rossi V.; Di Stefano G.; Manerba M., Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin, «PATHOLOGY ONCOLOGY RESEARCH», 2021, 27, Article number: 1609951 , pp. 1 - 9 [Scientific article]Open Access

Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; Farabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A., Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib, «JOURNAL OF MEDICINAL CHEMISTRY», 2020, 63, pp. 2588 - 2619 [Scientific article]Open Access

Manerba, Marcella; Govoni, Marzia; Manet, Ilse; Leale, Antoniofrancesco; Comparone, Antonietta; Di Stefano, Giuseppina, Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir, «BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS», 2019, 1863, pp. 1177 - 1186 [Scientific article]

Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, Domenico Milano, Elisa Giacomini, Federico Falchi, Andrea Balboni, Marcella Manerba, Fulvia Farabegoli, Francesca De Franco, Janet Robertson, Saverio Minucci, Isabella Pallavicini, Giuseppina Di Stefano, Stefania Girotto, Roberto Pellicciari, and Andrea Cavalli, Rad51/Brca2 Disruptors Inhibit Homologous Recombination and Synergize with Olaparib in Pancreatic Cancer Cells, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2019, 165, pp. 80 - 92 [Scientific article]

Manerba M, Di Ianni L, Govoni M, Comparone A, Di Stefano G., The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells, «PLOS ONE», 2018, 13, Article number: e0202588 , pp. 1 - 17 [Scientific article]Open Access

Manerba, Marcella; Di Ianni, Lorenza; Govoni, Marzia; Roberti, Marinella; Recanatini, Maurizio; Di Stefano, Giuseppina, Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells, «EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES», 2017, 96, pp. 37 - 44 [Scientific article]Open Access

Manerba, Marcella; Di Ianni, Lorenza; Govoni, Marzia; Roberti, Marinella; Recanatini, Maurizio; Di Stefano, Giuseppina, LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells, «EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES», 2017, 105, pp. 91 - 98 [Scientific article]Open Access

Falchi, Federico; Giacomini, Elisa; Masini, Tiziana; Boutard, Nicolas; Di Ianni, Lorenza; Manerba, Marcella; Farabegoli, Fulvia; Rossini, Lara; Robertson, Janet; Minucci, Saverio; Pallavicini, Isabella; Di Stefano, Giuseppina; Roberti, Marinella; Pellicciari, Roberto; Cavalli, Andrea, Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors, «ACS CHEMICAL BIOLOGY», 2017, 12, pp. 2491 - 2497 [Scientific article]

Di Stefano, Giuseppina; Manerba, Marcella; Di Ianni, Lorenza; Fiume, Luigi, Lactate dehydrogenase inhibition: Exploring possible applications beyond cancer treatment, «FUTURE MEDICINAL CHEMISTRY», 2016, 8, pp. 713 - 725 [Scientific article]

Rupiani, Sebastiano; Guidotti, Laura; Manerba, Marcella; Di Ianni, Lorenza; Giacomini, Elisa; Falchi, Federico; Di Stefano, Giuseppina; Roberti, Marinella; Recanatini, Maurizio, Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A, «ORGANIC & BIOMOLECULAR CHEMISTRY», 2016, 14, pp. 10981 - 10987 [Scientific article]