Laura Poppi, Samuel H Myers, Viola Previtali, Francesco Rinaldi, Fulvia Farabegoli, Giuseppina Di Stefano, Naomi Walsh, Marinella Roberti, Andrea Cavalli, A RAD51/BRCA2 small molecule inhibitor enhances the antineoplastic effect of the PARPi talazoparib in pancreatic cancer, in: EACR 2023: Innovative Cancer Science, 12-15 June 2023, Torino, Italy, FEBS PRESS, 2023, pp. 1 - 597 (atti di: EACR 2023: Innovative Cancer Science, Torino, Italy, 12-15 June 2023) [atti di convegno-poster]
Myers S. H., Poppi L., Rinaldi F., Veronesi M., Ciamarone A., Previtali V., Bagnolini G., Schipani F., Ortega Martínez J. A., Girotto S., Di Stefano G., Farabegoli F., Walsh N., De Franco F., Roberti M., Cavalli A., An 19F NMR fragment-based approach for the discovery and development of BRCA2-RAD51 inhibitors to pursuit synthetic lethality in combination with PARP inhibition in pancreatic cancer, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2023, 265, pp. 1 - 20 [articolo]
Rossi, Valentina; Govoni, Marzia; Di Stefano, Giuseppina, Lactate Can Modulate the Antineoplastic Effects of Doxorubicin and Relieve the Drug's Oxidative Damage on Cardiomyocytes, «CANCERS», 2023, 15, pp. 3728 - 3747 [articolo]Open Access
Valentina Rossi; Marzia Govoni; Giuseppina Di Stefano, Lactate preserves genome integrity and extends proliferative potential in cancer cells, in: EACR 2023: Innovative Cancer Science, 12-15 June 2023, Torino, Italy, FEBS PRESS, 2023, pp. 1 - 597 (atti di: EACR 2023: Innovative Cancer Science, Torino, Italy, 12-15 June 2023) [atti di convegno-poster]
Previtali V.; Myers S.H.; Poppi L.; Wynne K.; Casamassima I.; Girotto S.; Di Stefano G.; Farabegoli F.; Roberti M.; Oliviero G.; Cavalli A., Preomic profile of BxPC-3 cells after treatment with BRC4, «JOURNAL OF PROTEOMICS», 2023, 288, Article number: 104983, pp. 1 - 11 [articolo]
Iacovino L.G.; Rossi M.; Di Stefano G.; Rossi V.; Binda C.; Brigotti M.; Tomaselli F.; Pasti A.P.; Dal Piaz F.; Cerini S.; Hochkoeppler A., Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme, «BIOCHIMIE», 2022, 199, pp. 23 - 35 [articolo]Open Access
Pasti A.P.; Rossi V.; Di Stefano G.; Brigotti M.; Hochkoeppler A., Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme, «BIOSCIENCE REPORTS», 2022, 42, Article number: BSR20212654, pp. 1 - 19 [articolo]Open Access
Samuel Harry Myers , Viola Previtali, Laura Poppi, Francesco Rinaldi, Fabrizio Schipani, Jose Antonio Ortega, Francesca De Franco, Marina Veronesi, Roberto Pellicciari, Marinella Roberti, Stefania Girotto, Giuseppina Di Stefano, Andrea Cavalli, Identification and subsequent development of RAD51-BRCA2 disruptors through a fragment-based approach, in: ACS Spring 2022, 2022, pp. 1 - 1 (atti di: ACS Spring 2022, San Diego Convention Center, Room 16A, 20/03/2022) [atti di convegno-abstract]
Previtali V., Myers S. H., Bagnolini G., Poppi L., Rinaldi F., Schipani F., Ortega J. A., De Franco F., Pellicciari R., Girotto S., Oliviero G., Walsh N., Valenti G., Tirelli N., Di Stefano G., Roberti M., Cavalli A., Insights into the activity of ARN24089, a new RAD51-BRCA2 disruptor that inhibits homologous recombination and achieves synthetic lethality in pancreatic cancer, in: ACS Spring 2022, 2022, pp. 1 - 1 (atti di: ACS Spring 2022, San Diego Convention Center, Room 16A, 20/03/2023) [atti di convegno-abstract]
Rossi V.; Govoni M.; Farabegoli F.; Di Stefano G., Lactate is a potential promoter of tamoxifen resistance in MCF7 cells, «BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS», 2022, 1866, Article number: 130185, pp. 130185 - N/A [articolo]
Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea, The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2022, 23, Article number: 8338, pp. 1 - 14 [articolo]Open Access
Govoni M.; Rossi V.; Di Stefano G.; Manerba M., Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin, «PATHOLOGY ONCOLOGY RESEARCH», 2021, 27, Article number: 1609951, pp. 1 - 9 [articolo]Open Access
Balboni A.; Govoni M.; Rossi V.; Roberti M.; Cavalli A.; Di Stefano G.; Manerba M., Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment, «BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS», 2021, 1865, Article number: 129760, pp. 1 - 10 [articolo]
Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; Farabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A., Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib, «JOURNAL OF MEDICINAL CHEMISTRY», 2020, 63, pp. 2588 - 2619 [articolo]Open Access
Manerba, Marcella; Govoni, Marzia; Manet, Ilse; Leale, Antoniofrancesco; Comparone, Antonietta; Di Stefano, Giuseppina, Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir, «BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS», 2019, 1863, pp. 1177 - 1186 [articolo]
