Research Activities:
Scientific Research in the field of Experimental and
Clinico-Pathological studies on head and neck, neuroendocrine,
thyroid, lung , breast and gastro-intestinal tumor.
Full knowledge and use of diagnostic morphological
techniques (such as fluorescence in situ hybridization and
immunohistochemistry) and molecular (comparative genomic
hybridization analysis of clonality by analysis of the D-loop
region of mitochondrial DNA and the study of micro-RNA, Next
Generation Sequensing analysis), in 'field research and diagnostics
in surgical pathology and cytopathology.
Relevant Research results:
· the PI has
identified a new aggressive variant of thyroid carcinoma so called
the Hobnail papillary thyroid carcinoma as (see reference 17,
Asioli S et al Am J Surg Pathol 2010).
· the PI showed
an extension of the phenotypes associated with mutations in DICER1
including Head and Neck diseases ( see reference Foulkes WD et al.
Hum Mutat. 2011) in collaboration with the Research Institute,
McGill University Health Centre, Montreal, Quebec, Canada.
· Clinical
trials: HER-EAGLE (MO23009) faunded by Roche. Dr.
Giovanni Castegnaro, Clinical Research Associate, MediData
srl - Studi e Ricerche www.medidata.it c/o Centro servizi Città
Nova, Viale Virgilio 56/A, 41123 Modena, Italy Tel: +39 059
88.60.134, Fax: +39 059 84.83.05. Recruitment of patients
with HER2 positive advanced gastric adenocarcinoma closed in
February 2012.
Collaborations:
· Research
Collaborator of Laboratory Medicine and Pathology, Mayo Clinic,
Rochester, MN, USA
· Research
Collaborator of University of Madison, Wisconsin, USA.
· Research
Colaborator of the Research Institute, McGill University Health
Centre, Montreal, Quebec, Canada.
· Research
Colaborator of the, Department of Medicine, University of
Washington, Seattle, Washington 98109, USA.
Grant Proposals (Total =12 grants):
· Head of
research 8 projects funded by the University of Turin (ex-finance
60% MIUR, 5 projects 2008, 2009, 2010, 2011, 2012, 2013) and
by Regione Piemonte (Piedmont Healthcare Research aimed Region,
3 projects 2007, 2008, 2008-bis and 1 project of CRT
foundation 2008) See Websites: www.sitouniversitario.cineca.it and
http://www.ricerca-sanitaria-finalizzata.it.
Awards
Paired Related Homeobox 1 (PRRX1) Is Associated with
Epithelial-Mesenchymal Transition (EMT) in Thyroid Tumors . Garcia
CM, Guo Z, Hardin H, Buehler D, Nose V, Asioli S, et
al. was selected in the Stowell-Orbison/Surgical
Pathology/Autopsy Awards Poster Session at United States &
Canadian Academy of Pathology (USCAP) Annual Meeting 2014, San
Diego, CA, USA; Modern Pathology 2014 Feb.
Organisational skills :
· Member of
Endocrine Society of Pathology
· Member of
Endocrine Tumor Team of Romagna (NetteR)
· Member of
Merkel cell carcinoma Multi-center Interest Group
· Member of
Adriatic Society of Pathology.
· Member of
SIAPEC-IAP (Italian Society of Pathological Anatomy & Citology
– Italian division of International Academy of Pathology) sub-group
of Head and Neck pathology.
Publications:
Author of 71 publications, since 2002, on "peer review
journals", 4 book chapter, and 44 abstracts published on
peer review journals.
The current bibliometric data
are:
Articles published in journals with impact factor:
71/71
Impact Factor of the total journal papers:206,428
Impact Factor for the average article in a
journal:3.88
Number of citations: 1145 (Scopus), 912 (ISI Web of Science), 1543 (Google Scholar) h-index:20 (Scopus) 18 (ISI Web of Science), 23 (Google Scholar).
