Claudia Sebastiana Nobili pursued a degree in Classical Studies and graduated with honors in Italian Literature from the University of Bologna in 1993, with a thesis on Giovanni Boccaccio. She was later awarded a doctoral fellowship in "Theory and Analysis of Texts" at the University of Bergamo, where she deepened her studies in rhetoric and literary theory, expanding her research to early 20th-century literature and theater, with a particular focus on the works of Luigi Pirandello.
In 1998, Nobili was granted a postdoctoral fellowship at the University of Bologna, where she presented a project involving the translation and commentary of Salimbene de Adam’s "Chronica", which was published with a facing-text edition by the Istituto Poligrafico dello Stato. During this period, she also began teaching the course "Modern Italian Literature" for the American consortium of Vassar, Wellesley, and Wesleyan Universities.
From 2002 to 2014, she served as a researcher at the Faculty of Cultural Heritage Conservation at the University of Bologna. Following her appointment, Nobili continued her collaboration with American universities: she was invited by the University of California, Los Angeles (UCLA), to serve as a referee for the international journal "Viator: Medieval and Renaissance Studies", and she established ties with the Center for Italian Studies at the University of Pennsylvania in Philadelphia. She also spent time in the United States as a Visiting Professor: first in 2003 at Vassar College (NY), and again in 2008 at the University of Colorado, Boulder.
She authored the “Guida al ‘Fu Mattia Pascal'” (Carocci, 2004), and the volume "“«La materia del sogno». Pirandello tra racconto e visione»” (Giardini, 2007), in which Pirandello’s texts are examined through the lens of contemporary theatre and film theory. At the same time, she continued her work on Giovanni Boccaccio, organizing conferences and publishing essays dedicated to the Genealogy, Filocolo, and the Decameron. In 2014, she published an introductory study on Boccaccio’s works and the critical debate surrounding them (Unicopli), followed by a comprehensive volume released in 2017 by Longo Editore (Ravenna), titled "La consolazione della letteratura. Un itinerario fra Dante e Boccaccio". She has been invited to participate in numerous Lecturae Dantis and is a member of the scientific committee for the biennial International Dante Conference.
Since 2015, Nobili has served as Coordinator of the Degree Program in Cultural Heritage, as representative to the School Council of Humanities, and as Delegate for Teaching at the Department of Cultural Heritage (DBC) until 2023. At the university level, she has also served as a member of the Research Quality Assurance Board—representing the humanities area—by appointment of the Rector, and was a member of the University’s Teaching Observatory.
She is currently Full Professor of Italian Literature at the Department of Cultural Heritage (Ravenna campus), a member of the Governing Board of the Biblioteca Classense Institution, and a member of the University’s Quality Board for Doctoral Research. In 2023, she was elected to the Executive Committee of the Commissione per i Testi di Lingua and to the Scientific Council of the Società Dantesca Italiana.