Salvatore Nesci born in 1982, married, four children. He is Associate Professor (SDS
BIO/10 - Biochemistry) at the University of Bologna.
Degrees
- 2004 - B. Sc. in Biology, 110/110 cum laude, University
of Calabria
- 2006 - M. Sc. in Biology, 110/110 cum laude, University
of Calabria
Undergraduate training
Stage: Use of the confocal microscope, "Institute on
Membrane Technology" (ITM-CNR), Rende, Italy.
Training: Analysis of plasma proteins of membrane-grown
hepatic cells, "Institute on Membrane Technology" (ITM-CNR),
Rende, Italy.
Post-degree training and activities
- 2007 - qualification to the biologist profession.
- 2007 - 2010 - PhD in Biochemistry, Department of Biochemistry "G. Moruzzi", University of Bologna.
- September 2008 - March 2009 - Marco Polo fellowship and
visiting scientist at the Environmental Chemistry Department of
IDAEA-CSIC (formerly the IIQAB-CSIC) (Barcelona, Spain), under
the supervision of Dr. Cinta Porte.
- July 2010 - July 2012 - Postdoctoral Research Associate, Department of Veterinary Medical Sciences, University of Bologna.
- March 2012 - May 2012 - Marco Polo fellowship and visiting
scientist at the Medical Research Council: Mitochondrial Biology
Unit (Cambridge, UK) under the supervision of Dr. Michael P.
Murphy.
- December 2012 - November 2017 – Junior assistant professor (Scientific
Disciplinary Sector BIO/10 - Biochemistry), Department of
Veterinary Medical Sciences, University of Bologna.
- January 2013 - Present - Member of the Italian Society of
Biochemistry and Molecular Biology (SIB).
- July 2017 –Associate Professor Qualification for the disciplinary scientific sector BIO/10 - Biochemistry.
- November 2017 - november 2020 – Senior assistant professor (Scientific Disciplinary Sector BIO/10 - Biochemistry), Department of Veterinary Medical Sciences, University of Bologna.
- November 2020 - Present – Associate Professor (Scientific Disciplinary Sector BIO/10 - Biochemistry), Department of Veterinary Medical Sciences, University of Bologna.
- February 2022 – National Scientific qualification as full professor in the Italian higher education system for the disciplinary field of 05/E1 - General Biochemistry (Academic Recruitment Field 05/E - Experimental and clinical biochemistry and molecular biology, according to the national classification).
- October 2022 - Tutor of the “Collegio Superiore” of the University of Bologna.
- March 2023 – Eligibility to Full Professor, disciplinary field of 05/E1 - General Biochemistry sector BIO/10 – Biochemistry (RIF: O18C1II2022/1511/R22), in the procedure announced by the University of Bologna with DR 1953/2022 dated 03/12/2022 pursuant to art. 18 law 240/2010.
Grants, prizes, awards and on-going research projects
- 2008 - Marco Polo fellowship IDAEA–CSIC (formerly the IIQAB-CSIC) (Barcelona, Spain);
- 2012 - Marco Polo fellowship MRC-Mitochondrial Biology Unit (Cambridge, UK);
- 2013 - Young SIB (Italian Biochemical Society) Researchers Award;
- 2017 - Travel Fellowship of Membrane Group of SIB (Italian Biochemical Society);
- 2018 - PI of the one-year project “Mitochondrial permeability and F-ATPase: implications in high impact diseases in Emilia-Romagna” (CARISBO foundation, number 2017-0313);
- 2018 - Participant in the two-year project “Hydrogen sulphide as modulator of mitochondrial bioenergetics in cell function: effects under physio-pathological conditions and in phylogenetically distinct species, (University of Bologna Almaidea Senior Grant 2017).
- 2018 - PI of the Funding for Basic Research (FFABR 2017).
- 2019 - Participant in the one-year project “Mitochondrial permeability, aging and related diseases in Emilia-Romagna” (CARISBO foundation, number 2018-0375).
- 2020 - PI of the one-year project “Mitochondrial permeability transition pore modulation as a therapy for cardiovascular diseases of great impact in Emilia-Romagna” (CARISBO foundation, number 2019-0534).
- 2021- PI of the one-year project “Effects of bergamot polyphenols on human murine lipodystrophic adipocytes with LMNA gene mutations linked to aging diseases” (CARISBO foundation, number 2021/0173).
- 2022 - PI of the one-year project “Molecular strategies in mitochondria to limit cardiovascular damage in a porcine preclinical model of DCD (donation after cardiac death): mitochondrial permeability transition pore and F1FO-ATPase as biological targets” (Almaidea Grant 2022 – University of Bologna).
- 2023 – Co-PI of the two-year project “Mitochondrial dysfunction associated to permeability transition pore phenomenon in lung inflammation controls mitochondria-derived vesicles biogenesis and release in cystic fibrosis” (PRIN 2022 PNRR, n° P202242AFC), Italian Ministry of University and Research.
- 2023 - PI of the two-year projec “Dissecting a molecular mechanism for cardiac hypertrophy in hypertension: roles of mitochondrial NDUFC2-dependent Complex I dysfunction and of mitochondrial permeability transition” (PRIN Under40 2022, n° 2022E75TWB), Italian Ministry of University and Research.
Research interests and skills
Great interest in the mitochondrial bioenergetics, in particular
for the enzymatic catalysis of F1FO-ATPase and the electron
transport chain.
Scientific expertise acquired:
The mitochondrial F1FO-ATPase activity and kinetics and
mitochondrial respiration analysis.
Proteomic techniques to the characterization of protein thiols
modification in mitochondria.
Head Space Solid Phase MicroExtraction (HS-SPME) coupled with
gas chromatography (GC) for organotin analysis.
The endocrine system, detoxification mechanisms and lipid
metabolism analysis.
Guest Editor of Special Issue
- “Mitochondrial Biology in Health and Disease” of the Frontiers in Bioscience-Landmark;
- "Cell Metabolism and Small Natural Compounds" of the International Journal of Molecular Sciences;
- "Molecular targets to counteract the mitochondrial dysfunctions associated with cardiovascular diseases: in the search of new molecules" of the Pharmacological Research;
- "Impaired Mitochondrial Bioenergetics under Pathological Conditions" of the Life;
- "Multiple Enzyme Mechanism and Functions in Mitochondrial Biology" of the International Journal of Molecular Sciences;
- "Nutraceuticals and Membrane Transport Systems: Beneficial Effects on Human Health" of the Frontiers in Pharmacology and Frontiers in Physiology.
Editorial board member
- “Cellular Metabolism Therapy” Section Editor of Journal of Translational Medicine;
- Associate Editor of Journal of Biochemical and Molecular Toxicology;
- Associate Editor in “Protein Biochemistry for Basic and Applied Sciences” section of Frontiers in Molecular Biosciences;
- Associate Editor in “Nutrition & metabolism” section of Journal of Translational Medicine;
- Associate Editor of Bioenergetics Communications;
- Editorial Board member of Medicinal Research Reviews;
- Topic Editor for Life.
Journal referee
Signal Transduction and Targeted Therapy; ACS Medicinal Chemistry Letters; Redox Biology; Journal of Pharmaceutical Analysis; PLOS ONE; Journal of Bioenergetics and Biomembranes; Analytical Chemistry; Current Medicinal Chemistry; BBA - Molecular Cell Research; Obesity Reviews; Medicinal Chemistry Letters; Journal of Physiology; Journal of Medicinal Chemistry; Biochemical and Biophysical Research Communications; Pharmacological Research; Journal of Medical Virology; Trends in Pharmacological Sciences; International Immunopharmacology; Ecotoxicology and Environmental Safety; Disease Models & Mechanisms; Frontiers in Endocrinology; Membranes; iScience; Journal of Cellular Physiology; Human Mutation; Biology; European Journal of Clinical Investigation; European Journal of Cell Biology; Journal of Global Antimicrobial Resistance; BBA Biomembranes; Cell Death and Disease; Cells; Drug Discovery Today; Biotechnology Journal; Environmental Science and Pollution Research; Frontiers in Physiology; Chemosphere; Process Biochemistry; Comparative Biochemistry and Physiology – Part C; Environmental Pollution; Journal of Food Composition and Analysis.
Reviewer
- Grant evaluator for “Kuwait Foundation for the Advancement of Sciences” 2024
- Grant evaluator for “The Netherlands Organisation for Scientific Research” 2024
- Grant evaluator for “National Science Center Poland” 2024
- Grant evaluator for “Basic Research Evaluation 2017 – University of Verona”.
- Appointment of external auditor VQR 2015-19.
