Foto del docente

Pier Luigi Martelli

Full Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/10 Biochemistry

Director of Second Cycle Degree in Bioinformatics

Research

The research activity of PLM focuses on the development of systems based on Neural Networks, Hidden Markov Models and Support Vector Machines for the prediction of functional and structural features in proteins. In particular he developed systems for the prediction of the secondary structure of proteins, of the topology and topography of membrane proteins (both from inner and outer membranes), of the bonding state of cysteines, of the subcellular localization. Moreover he studied and simulated the protein folding process, he modelled the structure of different proteins,  integrating computational and experimental information, he analysed the interaction between proteins and ligands by means of docking procedures and molecular dynamics simulations.


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