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Pier Giorgio Cozzi

Full Professor

Department of Chemistry "Giacomo Ciamician"

Academic discipline: CHIM/06 Organic Chemistry

Curriculum vitae

Birth-date: 07/25/1963            Nationality: Italian      Status: married, with Maria Dimoglou (Greek)


Home Address: Via A. Manarini 20, Ferrara (Italy). Tel. 0532-7903680532-790368. Cell phone 0039-340-14288330039-340-1428833


Professional Address : Dipartimento Di Chmica “G. Ciamician”, Via Selmi 2, 40126 Bologna, Italy.

Fax: 0039-051-2099456. Tel. 0039-051-20995110039-051-2099511.


Higher Education:

04/1991 to 10/1994 Research Associate at the University of Lausanne under the supervision of Prof. C. Floriani.

05/1988 to 01/1989 Laurea (5 years course work, including 13 organic courses and 17 other courses in chemistry, mathematics, and physics) at the University of Milan. Undergraduate thesis under the direction of Prof. C. Gennari.


Work experience and related subjects:

10/1994 to 2001 Permanent position as assistant (tenured) professor at the University of Bologna. 2001-2014 Permanent position as associate professor at Bologna University. The development of new, enantioselective catalytic reactions through an extensive knowledge of organic and inorganic literature and through experimental planning is my principal interest. Self-assembled chiral catalysts based on calixarenes and BINOL Lewis acid systems were studied and some promising preliminary results in this area have been published Titanium tetrafluoride and other inorganic fluorides was used in our laboratory as precursor of interesting new catalyst systems, used for example, in enantioselective catalytic reduction of ketones. Chiral Schiff bases complexes of group IV transition metals were used in promoting new interesting high diastereoselective carbon-carbon bond formation reactions. Chiral Shiff bases metal complexes of Cr, V, Co, In, and Sm were used in enantioselective mediated redox reactions. With professor S. Gambarotta (Ottawa) I have investigated the chemistry of bis-pyrrole and pyrroleBox ligands. The organometallic chemistry of U, Tm and Sm surrounded by chiral ligands was also explored. With drs. P. Van der Schaaf, U. Berens, N. End (CIBA) there was have a strong collaboration in the field of ligands design. One patent was filed. We have developed a new class of P,N –ligands based on heterocycle scaffolds (HetPHOX) and PyrPHOX that are cited on Books (Hartwig textbook). Furthermore, the experience in the fields allows the design of three different class of BOX ligands that give really interesting results in catalysis (IMOX, AlcOX). The formation of quaternary stereocenters with new synthetic methodologies were also investigated in our laboratory. The first enantioselective addition of alkynes to ketones was described. We have developed catalytic enantioselective variant of Imino-Reformatsky and Reformatsky reactions, and the first enantioselective addition of diazoacetate to ketones. Recently the laboratory was shifting the interest in more environmentally friendly reaction conditions. It was introduced new effective reaction promoted “on Water” and the chemistry of SN1-reaction with ferrocenyl alcohols for the preparation of chiral ligand, starting material for electronics, was investigated. Through an effective and rewarding European grant (w.w.w CATAFLU.OR. eu ) we have investigated new stereoselective organocatalytic reactions. By starting from no experience the group has introduced a new developing area in catalysis, the stereoselective SN1-type reactions that are now under investigations also in organometallic chemistry. Quite new interesting and highly stereoselective SN1 reactions were introduced, and these concepts were recently highlighted an Angewandte Chemie and in Synlett account. Professor Pier Giorgio Cozzi is active also in the design of ferrocene compounds for computation through QCA (MolarNet project), use of graphene and graphene oxide for catalysis, and functionalization of graphite, gold, ITO, and silica surfaces with tailored molecules for electronics.

9/2006 to 10/2006 Visiting professor in the Polytechnique of Hong Kong and SunYatSen University (QuangZhou, China). I have presented 4 lectures and I have started new catalytic enantioselective reactions in the field of alkynylation.

01/ 2003 to 02/2003 Visiting professor in the institute of Organic Chemistry , University of Aachen(Germany). I have presented 4 lessons to the Ph.D. student of the University of Aachen. 1) Chiral Schiff bases: conformations aggregation and multimetallic activation in catalysis. 2) Design and synthesis of chiral heterocyclic privileged ligands. 3) Catalytic enantioselective redox reactions. 3) Organocatalysis: proline, carbenes and something else. Working in the laboratory of professor Carsten Bolm I have discovered a new methodology for the preparation of chiral b-lactams and I have crystallized a copper chiral sulfoximine complex (first example in the literature). 

07/2002 to 08/2002 Visiting scientist with Professor Thomas Ward (3 weeks, Neuchătel, Switzerland). The synthesis of interesting new achiral ligands capable to select interaction with a protein was developed. The chiral ligands was used encapsulated in a protein to promote enantioselective transformation. The concept is new and really important.

07/2002 to 08/2002 Visiting scientist with Dr. Paul Van der Schaaf  at Ciba (1 week, Ciba, Basel). Further work on chiral ligands.

01/2002 to 02/2002 Visiting scientist with Dr. Paul Van der Schaaf  at Ciba (Ciba, Basel). I have developed a general synthesis for chiral ligands. The synthesis and properties of the ligands were studied and preliminary interesting results were obtained.

07/2001 to 08/2001 Visiting scientist with Professor S. Gambarotta (Ottawa). During this period 5 new ligands containing pyrrole were prepared. The structure of two of them were determined by X-ray ananlysis. Work is in progress to prepare new materials and complexes and to use these complexes in catalysis. The collaboration with professor Gambarotta is still in course.

10/2000 to 11/2000 Visiting scientist with Dr.s Andreas Hafner and Dr. Paul Van der Schaaf  at Ciba (Ciba, Basel). The work was successful in exploring a class of potentially useful ligands based on heterocycle scaffold (HetPHOX). The ligads were recently patented and will be described in ICOS-14 meeting.

08/2000 to 09/2000 Visiting scientist with prof. Karl Anker Jørgensen at Aarhüs University (Aarhüs, Denmark). During this short period was examined a catalytic enantioselective metathesis reaction based on ruthenium and the catalytic addition of R2Zn to activated iminoesters. In the second project promising results were obtained.

08/1999 to 09/1999 Visiting scientist with Prof. Andreas Pfaltz at Basel University (Basel, Switzerland). The preparation of new efficient and promising Phosphino-oxazoline for the enantioselective reduction of non functionalyzed double bond were developed.

07/1998 to 09/1998 Visiting scientist with Dr.s Andreas Hafner and Michael Tinkl at Ciba Specialty in Marly, (Fribourg, Switzerland). During this period i was successful in developing a new palladium  based methodology for the preparation of fine chemicals.

07/1997 to 09/1997 Visiting scientist with Prof. S.L. Regen at Lehigh University (Pa, USA). The preparation of new membrane device for the gas separation were accomplish using (PTMSP) as supporting material, a-cyclodextrine/sodium phenoxide as gutter layer, and a single monolayer of  a substituted calix[6]arene as primary barrier for the transport.

04/1991 to 10/1994 “Assistant diplomeè” n inorganic and organometallic chemistry at Lausanne University.  This work was oriented toward the study and development of organometallic Lewis acids, metal enolates, and organometallic intermediates, most of which were fully characterized in the solid state and in solution.

02/1990 to 03/1991 “Borsa di studio” with Prof. M. Cinquini and Prof. F. Cozzi at the University of Milan. During this period I played a considerable role in developing a new methodology for the synthesis of b-lactams using titanium enolates.

02/1989 to 10/1990 “Borsa di studio”  with Prof. C. Scolastico at the University of Milan. During this period, we achieved the total synthesis of an alkaloid and this compound showed interesting properties related to neurotoxin activity.

05/1988 to 01/1989 Graduate research at the University of Milan under the supervision of Prof. C. Gennari. Under his supervision, I reached a good level of expertise with enantioselective and diastereoselective Lewis acid-promoted reactions.


Language Proficiency. Fluently in English (written and oral) and French (oral). Italian native speaker.

Publications. 140 Publications on international journal, 3 patent,

Presentations. 13 oral presentation to international congress. More than 95 presentations to University, European Meetings and Industries.


Coordination and networking activity. Professor Pier Giorgio Cozzi has participated to two European Network in the 6th European Program (FP6).

1) The European ligbank® (

2) The IBA2C network

Professor Pier Giorgio Cozzi was the coordinator of the project CATAFLU.OR in FP7. (

4) Professor Pier Giorgio Cozzi was participating to the Marie Curie training network BioChemLig (FP7)

5) Professor Pier Giorgio Cozzi is participating to the European Network MolArNet( FP7).



1. The top 10 publications, as senior author

1.      Andrea Gualandi, Enriico Emer, Montse Guiteras Capdevila, Pier Giorgio Cozzi. Highly Enantioselective α Alkylation of aldehdyes with 1,3 Benzodithyolylium tetrafluoborate. Angew. Chem. Int. Ed. 2011, 50, 7842.

2.      Organocatalytic Asymmetric Alkylation of Aldehydes by SN1-Type Reaction of Alcohols P.G. Cozzi, F. Benfatti, L. Zoli, L Angew. Chem. Int. Ed. 2009, 48, 1313.

3.      A rational approach towards the nucleophilic substitutions of alcohols "on Water" P. G. Cozzi, L. Zoli L. Angew. Chem. Int. Ed. 2008, 47, 4162.

4.      Catalytic stereoselective benzylic C-H functionalizations by oxidative C-H activation and organocatalysis F. Benfatti, M. G.Capdevila, L. Zoli, E. Benedetto, P. G. Cozzi. Chem. Comm. 2009, 5919.

5.      A catalytic, Me2Zn-mediated, enantioselective reformatsky reaction with ketones P. G. Cozzi, Angew. Chem. Int. Ed. 2006, 45, 2951.

6.      A catalytic enantioselective imino-reformatsky reaction P. G. Cozzi, Adv. Synth. Catal. 2006, 348, 2075.

7.      Highly enantioselective addition of Me2Zn to aldehydes catalyzed by ClCr(Salen) P. G. Cozzi, P. Kotrusz J. Am. Chem. Soc. 2006, 128, 4940.

8.      Enantioselective alkynylation of ketones catalyzed by Zn(salen) complexes P. G. Cozzi, Angew. Chem. Int. Ed. 2003, 42, 2895.

9.      Metal-Salen Schiff base complexes in catalysis: practical aspects P. G. Cozzi Chem. Soc. Rev. 2004, 7, 410.

10.  The first catalytic enantioselective Nozaki-Hiyama reaction M. Bandini, P. G. Cozzi, P. Melchiorre, A. Umani-Ronchi. Angew. Chem. Int. Ed. 1999, 38, 3357.


3.      Patents

1)      Bistable carbazole compounds. Bramanti, Alessandro Paolo; Cozzi, Piergiorgio; Zoli, Luca (2012), IT 1391578 B1 20120111.

2)      Method for the synthesis of dipyrromethanes by "on water" reaction of aldehydes with pyrrole derivatives. (2011), IT 1390796 B1 20111019.

3)      Bistable carbazole compounds with transition metals as quantum computer components. Cozzi, Pier Giorgio; Zoli, Luca; Bramanti, Alessandro Paolo. U.S. Pat. Appl. Publ. (2011), US 20110155996 A1 20110630.

4)      Bistable carbazole compounds. Cozzi, Pier Giorgio; Zoli, Luca; Bramanti, Alessandro Paolo

5)      PCT Int. Appl. (2010), WO 2010028836 A1 20100318.  | 

6)      Preparation of isoxazoline derivatives and their use in stereoselective transition metal catalyzed reactions. End, Nicole; Stoessel, Catherine; Berens, Ulrich; Cozzi, Pier Giorgio. PCT Int. Appl. (2003), WO 2003014133 A1 20030220.


4. Invited presentations on selected International Meetings

-          XXIII International Symposium on Medicinal Chemistry (EFMC-ISMC) 2014, (Lisbon, Portugal) Invited key lecture.

-          VI International School On Organometallic Chemistry Marcial Moreno Mañas 2013, (Alicante, Spain). Invited plenary lecture

-          XXXVIII International Summer School on Organic Synthesis  "A. Corbella", 2013 (Gargnano, Italy), invited lecture.

-          ORCA Meeting 2012 (Athens, Greece) Invited Plenary lecture

-          CoGICo 2012 (Padua, Italy) Invited lecture

-          ANORQ Meeting 2012 (Caen, France) Invited plenary lecture

-          ESOC 2011 (Crete, Greece) Oral communication

-          ISCHIA Advanced School of Organic Chemistry.(Ischia Italy) Plenary lecture. 2010

-          SISOC VII Spanish-Italian Symposium of Organic Chemistry. (Oviedo, Spain). Invited lecture 2008.

-          OMCOS 14 (Nara, Japan). Invited lecture.2007

-          OMCOS 13 (Geneve, Switzerland). Oral communication 2005.

-          OMCOS 11 (Paris, France). Oral communication. 1999.

-          ICOS 11 (Christchurch, New Zealand). Oral communication. 1998.


-          Professor Pier Giorgio Cozzi has presented 3-4 lectures in all European Projects who has participate.

-          In addition in the project CATAFLU.OR Porfessor Cozzi has delivered four plenary lectures (Guangzhou, Hong Kong, 2 lectures, and Bratislava)

-          Professor Pier Giorgio Cozzi was invited in Japan for a series of 6 lecture by professor K. Maruoka in 2012. He was presented 6 lectures in Kyoto, Osaka, Nagoya, and Tokyo.


5. Research expeditions.

Professor Pier Giorgio Cozzi is the coordinator of the project CATAFLU.OR in the contest of FP7 financed with 2700000 Euros. Professor Pier Giorgio Cozzi was participating to Italian research projects all financed in the last 10 years.

6. Organization of International conferences.

1) European Workshop of Organocatalysis and final CATAFLU.OR meeting (2011).

2) CATAFLU.OR meeting (Bologna 2008)

3) IBAAC Meeting (Bologna 2007)


7. International Prizes/Awards/Academy memberships.

P G Cozzi received the 2007 C.I.N.M.P.I.S. award.

P. G. Cozzi was awarded two times by Royal Society of Chemistry (grants for International Authors). 1999. For promoting a visit to Professor A. Pfaltz. 2005. For promoting a visit to Professor A. Chan (Hong Kong).

In 2014 PG Cozzi was awarded by Chemical Society of Japan of a JSPS Fellowship under the FY2014 Program for Research. He will visit Japan and presenting more than 12 lectures in November 2014.


in 2015 PG Cozi received the P. Pino medal award from Italian Chemical Society


8. Major contributions to early careers of excellent researchers

P G. Cozzi has been the advisor brilliant young scientist. During his career Professor Pier Giorgio Cozzi has trained more than 25 MS students and 7 PhD students. He has supervised more than 10 postdocs coming from different countries (India, Belgium, Switzerland, Spain, France, Italy, Slovakia).

Professor Paolo Melchiorrre (ICIQ, Tarragona, Spain) that was recently awarded an ERC starting grant.

Professor Marco Bandini (Bologna University, Bologna, Italy). He was going through the first step of ERC selection for starting grant.


Highlights. a)The First Catalytic Enanatioselective Nozaki Hiyama Reaction. Bandini, M.; Cozzi, P.G.; Melchiorre, P.; Umani-Ronchi, A. Angew. Chem., Int. Ed. Engl., 1999,38, 3357 (VIP paper in Angewandte Chemie).

b) Enantioselective Alkynylation of Ketones Catalyzed by Zn(Salen) Complexes. P.G. Cozzi, Angew. Chem. Int. Ed. 2003, 42, 2895-2898. (HOT paper in Angewandte Chemie).

c) One-pot Three component Imino-Reformatsky Reaction, Cozzi P.G., Rivalta E. Highly Enantioselective Angew. Chem. Int. Ed., 2005, 44, 3600. (HOT paper in Angewandte Chemie).

d) Me2Zn Mediated Catalytic Enantioselective Reformatsky Reaction with Ketones Cozzi P. G.,. Angew. Chem. Int. Ed. 2006, 45, 2951. (HOT paper in Angewandte Chemie).

e) Pier Giorgio Cozzi , Luca Zoli A rational Approach Towards the Nucleophilics Substitution of Alcohols “on water”. Angew. Chem. Int . Ed . 2008, 47, 4162.(HOT paper in Angewandte Chemie)

f) Pier Giorgio Cozzi , Fides Benfatti, Luca Zoli Direct Nucleophilic substitution of  Alcohols “on water”. Angew. Chem. Int . Ed . 2009, 48, 1312.(HOT paper in Angewandte Chemie). This work was the Synfact of the month and was highlighted in ChemCatChem.

g) Andrea Gualandi, Enriico Emer, Montse Guiteras Capdevila, Pier Giorgio Cozzi. Highly Enantioselective α Alkylation of aldehdyes with 1,3 Benzodithyolylium tetrafluoborate. Angew. Chem. Int. Ed. 2011, 50, 7842. (VIP paper in Angewandte Chemie and Inside Cover). This work was highlighted in Angewandte Chemie and Synfact.


Professor Pier Giorgio Cozzi has published the 10th Angewandte paper since 2000 in 2010 and has published the author Page on angewandte Chemie.


From Web of Knowledge citation report:

Results found:                                                 137

Sum of the Times Cited :                                5687

Average Citations per Item:                            41.51


h-index: 43.


Guest Editor

P. G. Cozzi will be a Guest Editor for  the issue “Organocatalysis” published in 2012 by ChemCatChem.

The project CATAFLU.OR of the Fp7 coordinated by Professor pier Giorgio Cozzi was highlighted and received a COVER picture on ChemCatChem.


International Advisory Board

Professor P.G.Cozzi is in the International Advisory Board of ChemPlusChem and Asian Journal of Organic Chemistry. Is also in the Boards of: Letters in Organic Chemistry, Current Chemical Biology, Current Organic Chemistry.


Participation to institutionnel charges

P. G. Cozzi is actively participating to the PhD school in Bologna University, organizing the lectures for organic Chemistry Course. In 2013 he has organized a mini symposium with four chemists working in industry. Normally  2-3 distinguished speakers are always invited to deliver lectures seminar in PhD school.



Societá Chimica Italiana (from 2010)

American Chemical Society ACS (from 2004)


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