Foto del docente

Manuela Bartolini

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/08 Pharmaceutical Chemistry


Keywords: IMERs (Immobilized Enzyme Reactors) Alzheimer's disease spectrophotometric and fluorometric techniques Proteomics and glycomics Biorecognition phenomena

- Alzheimer's disease. Studies of structure-activity relationships and mechanism of action of new synthetic and natural compounds on target enzymes (acetylcholinesterase and butyrylcolinesterase) and aggregation of beta amyloid peptide.

- Advanced analytical methods in drug discovery, glycomics and proteomics. Development of bioreactors containing immobilized enzymes for the on-line evaluation of biologically active compounds, for protein digestion in proteomic approaches and for protein deglycosylation in glycomic approaches.

- Diabetes mellitus. Investigation of the role of advanced glycation end-products in the onset of chronic complications of diabetes associated with RAGE activation.

- Investigation of biorecognition phenomena by optical biosensor.