Dr Fiori's scientific activity has been mainly focused on the
development of new analytical methods for the characterization and
dosage of drugs and bioactive molecules. The methodologies involved
in these studies are spectroscopic techniques such as UV and mass
spectrometry (MS), separation techniques, like liquid
chromatography (HPLC), gas chromatography (GC), and combined
techniques, i.e. LC-MS, GC-MS, MALDI-MS (Matrix Assisted Laser
Desorption Ionization – MS).
The research interests and applications are:
- Medicinal chemistry (characterization, determination, dosage,
photoreactivity, stability of drugs, natural compounds and
bioactive molecules).
- Complex matrices (pharmaceutical formulations, medicated
feedstuff, cellular and vegetal extracts, biological fluids).
- Proteomics (peptides, biomarkers, proteins mutation,
acetilation and isoforms, protein-protein interactions,
proteins-drug interactions).
- Microbiology (interaction between bacteria and human
proteins).
- Metabolomics (Very recently she focused her interest on gut
microbiota metabolites, as short chain fatty acids (SCFAs) and methylamines (TMA, TMOA), which
provide a relevant contribution to the host's nutritional,
immunological and physiological status).
The studies were often carried out in collaboration with
research groups within the Faculty of Pharmacy, or with Companies
(GlaxoSmithKline, Endura, TreI).
Dr Fiori was also involved in an European project (BISNES)
focused on the design, fabrication and implementation of biomimetic
nanostructures which complement biomolecular surfaces and modulate
the biomolecular activity.
Dr Fiori in these years is co-author in 57 papers on
international journal and of numerous communication at national and
international meetings.
