Foto del docente

Jessica Fiori

Assistant professor

Department of Chemistry "Giacomo Ciamician"

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Research

Dr Fiori's scientific activity has been mainly focused on the development of new analytical methods for the characterization and dosage of drugs and bioactive molecules. The methodologies involved in these studies are spectroscopic techniques such as UV and mass spectrometry (MS), separation techniques, like liquid chromatography (HPLC), gas chromatography (GC), and combined techniques, i.e. LC-MS, GC-MS, MALDI-MS (Matrix Assisted Laser Desorption Ionization – MS).

The research interests and applications are:     

- Medicinal chemistry (characterization, determination, dosage, photoreactivity, stability of drugs, natural compounds and bioactive molecules).

- Complex matrices (pharmaceutical formulations, medicated feedstuff, cellular and vegetal extracts, biological fluids).

- Proteomics (peptides, biomarkers, proteins mutation, acetilation and isoforms, protein-protein interactions, proteins-drug interactions).

- Microbiology (interaction between bacteria and human proteins).

- Metabolomics (Very recently she focused her interest on gut microbiota metabolites, as short chain fatty acids (SCFAs) and methylamines (TMA, TMOA), which provide a relevant contribution to the host's nutritional, immunological and physiological status).

The studies were often carried out in collaboration with research groups within the Faculty of Pharmacy, or with Companies (GlaxoSmithKline, Endura, TreI).

Dr Fiori was also involved in an European project (BISNES) focused on the design, fabrication and implementation of biomimetic nanostructures which complement biomolecular surfaces and modulate the biomolecular activity.

Dr Fiori in these years is co-author in 57 papers on international journal and of numerous communication at national and international meetings.

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