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Jessica Fiori

Assistant professor

Department of Chemistry "Giacomo Ciamician"

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Curriculum vitae

From 2009 Jessica Fiori is assistant professor in Medicinal Chemistry at the University of Bologna. Her current research activity is devoted to mass spectrometric strategies for the identification and characterization of bioactive molecules or natural compounds in different matrices and for the study of peptides involved in protein aggregation disorders such as Alzheimer’s disease. Very recently she focused her interest on proteins and peptides involved in pathological events and on gut microbiota metabolites, which provide a relevant contribution to the host’s nutritional, immunological and physiological status. She is author and co-author of many scientific articles published on peer reviewed international journals.

Education

Master Degree in Chemistry and Pharmaceutical Technology in 1998 from the University of Bologna, PhD in Pharmaceutical Sciences, 2003, from the same University for studies regarding the photochemical properties of drugs.

Academic career

After several years of post-doc fellowship, since December 2008 she works as assistant professor in Medicinal Chemistry at the Department of Pharmacy and Biotechnology and from 2018 at the Department of Chemistry "G. Ciamician, University of Bologna. In 2015 she obtained the National Scientific Qualification as Associate Professor in Medicinal Chemistry. In 2018 she obtained the National Scientific Qualification as Associate Professor in Analytical Chemistry. In 2000 she spent a research period at GlaxoSmithKline (Ware, United Kingdom), carrying out a research project aimed at the development of analytical methodology for photostability studies on drugs; in 2005 she collaborated with the Prof. A. P. Bruins group at the Mass Spectrometry Core Facility, University of Groningen (The Netherland), working on the optimization of conditions for effective electrochemical cleavage of peptides and proteins.

Scientific activities

Her work at the Department of Chemistry has been mainly focused on the development of new analytical methods for the characterization and dosage of drugs and bioactive molecules. The methodologies involved in these studies are spectroscopic techniques such as UV and mass spectrometry (MS), separation techniques, like liquid chromatography (HPLC), gas chromatography (GC), and combined techniques, i.e. LC-MS, GC-MS, MALDI-MS (Matrix Assisted Laser Desorption Ionization – MS). The research interests and applications are: (i) medicinal chemistry (characterization, determination, dosage of drugs, natural compounds and bioactive molecules in complex matrices); (ii)  proteins, peptides, biomarkers, proteins mutation, acetilation and isoforms, protein-protein interactions for the study of different pathologies; (iii) microbiology, interaction between bacteria and human proteins and, very recently, the determination of gut microbiota metabolites, which provide a relevant contribution to the host's nutritional, immunological and physiological status.She has established national and international scientific collaborations. Dr. Fiori is the author of 67 papers on international journals, one book chapter, and several oral communications at international congresses. 

Teaching activities

From 2018: Professor of Cosmetic ingredient analysis and quality assurance_Unit 1 Cosmetig ingredient analysis, Master degree in Advanced Cosmetic Sciences, Università di Bologna, Polo di Rimini.

Dal 2009 al 2016: teaching activity at the corse of Analisi farmaceutica II and Analisi dei Prodotti per la Salute II, 1st cycle degree Controllo di Qualità dei Prodotti per la Salute (CQPS), Scuola di Farmacia e Biotecnologie, Università di Bologna, Polo di Rimini.

International and national research projects, selected for funding based on calls that involved competitive peer-reviewed

2017. Antibiotic prophylaxis in infants with congenital abnormalities of kidney and urinary tract: the impact of the developmental trajectory of gut microbiome assembly, metabolic programming and the gut resistome profile. Progetto finanziato dalla ricerca finalizzata, Ministero della Salute (Project code RF-2016-02363563), WP leader of the Università of Bologna.

2016. Plant food in human evolution: Factors affecting the harvest of nutrients from the floral environment (HARVEST), ERC Starting Grant 2015, Collaborator.

2015-2018. Innovative Food Product Development Cycle: Frame for Stepping Up Research Excellence of FINS – FOODstars. H2020-TWINN-2015 (H2020-EU.4.b. - Twinning of research institutions, project ID: 692276), Collaborator.

2015. Composition of Gut Microbiota and impact on immune system recovery and acute graft versus host disease in pediatric patients undergoing hematopoietic stem cell transplantation”. Finanziato dalla ricerca finalizzata, Ministero della Salute (Project code GR-2013-02357136), Collaborator.

2007-2013. Bio-Inspired Self-assembled Nano-Eanabled Surfaces (BISNES), FP7 SEVENTH FRAMEWORK PROGRAMME THEME 4 NMP - Nanosciences, Nanotechnologies, Materials and new Production Technologies (H2020, Grant No. 214538), Collaborator.

Referee for international scientific journals

Referee for the following international scientific journals: Analytica Chimica Acta, Chromatographia, Journal of Chromatography A, Journal of Pharmaceutical and Biomedical Analysis, Analytical Letters.

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