Foto del docente

Giovanni Perini

Full Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/18 Genetics

Director of First Cycle Degree in Biotechnology

Publications

Mercatelli D.; Balboni N.; Palma A.; Aleo E.; Sanna P.P.; Perini G.; Giorgi F.M., Single-cell gene network analysis and transcriptional landscape of MYCN-amplified neuroblastoma cell lines, «BIOMOLECULES», 2021, 11, pp. 1 - 18 [Scientific article]

Milazzo G.; Mercatelli D.; Di Muzio G.; Triboli L.; De Rosa P.; Perini G.; Giorgi F.M., Histone deacetylases (HDACs): Evolution, specificity, role in transcriptional complexes, and pharmacological actionability, «GENES», 2020, 11, pp. 1 - 49 [Scientific article]

Mzoughi, Slim; Fong, Jia Yi; Papadopoli, David; Koh, Cheryl M; Hulea, Laura; Pigini, Paolo; Di Tullio, Federico; Andreacchio, Giuseppe; Hoppe, Michal Marek; Wollmann, Heike; Low, Diana; Caldez, Matias J; Peng, Yanfen; Torre, Denis; Zhao, Julia N; Uchenunu, Oro; Varano, Gabriele; Motofeanu, Corina-Mihaela; Lakshmanan, Manikandan; Teo, Shun Xie; Wun, Cheng Mun; Perini, Giovanni; Tan, Soo Yong; Ong, Chee Bing; Al-Haddawi, Muthafar; Rajarethinam, Ravisankar; Hue, Susan Swee-Shan; Lim, Soon Thye; Ong, Choon Kiat; Huang, Dachuan; Ng, Siok-Bian; Bernstein, Emily; Hasson, Dan; Wee, Keng Boon; Kaldis, Philipp; Jeyasekharan, Anand; Dominguez-Sola, David; Topisirovic, Ivan; Guccione, Ernesto, PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis, «NATURE COMMUNICATIONS», 2020, 11, pp. 3520 - 3533 [Scientific article]

Bibbo' S.; Lamolinara A.; Capone E.; Purgato S.; Tsakaneli A.; Panella V.; Sallese M.; Rossi C.; Ciufici P.; Nieddu V.; De Laurenzi V.; Iezzi M.; Perini G.; Sala G.; Sala A., Repurposing a psychoactive drug for children with cancer: p27 Kip1-dependent inhibition of metastatic neuroblastomas by Prozac, «ONCOGENESIS», 2020, 9, pp. 1 - 8 [Scientific article]Open Access

Roberto Bernardoni, Giorgia Giordani, Elisabetta Signorino, Sara Monticelli, Francesca Messa, Monica Pradotto, Valentina Rosso, Enrico Bracco, Angela Giangrande, Giovanni Perini, Giuseppe Saglio, Daniela Cilloni, A new BCR-ABL1 Drosophila model as a powerful tool to elucidate pathogenesis and progression of chronic myeloid leukemia, «HAEMATOLOGICA», 2019, 104, pp. 717 - 728 [Scientific article]Open Access

Koach, Jessica; Holien, Jessica K; Massudi, Hassina; Carter, Daniel R; Ciampa, Olivia C; Herath, Mika; Lim, Taylor; Seneviratne, Janith A; Milazzo, Giorgio; Murray, Jayne E; McCarroll, Joshua A; Liu, Bing; Mayoh, Chelsea; Keenan, Bryce; Stevenson, Brendan W; Gorman, Michael A; Bell, Jessica L; Doughty, Larissa; Hüttelmaier, Stefan; Oberthuer, Andre; Fischer, Matthias; Gifford, Andrew J; Liu, Tao; Zhang, Xiaoling; Zhu, Shizhen; Gustafson, W Clay; Haber, Michelle; Norris, Murray D; Fletcher, Jamie I; Perini, Giovanni; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M, Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface, «CANCER RESEARCH», 2019, 79, pp. 5652 - 5667 [Scientific article]

Laura D. Gamble, Stefania Purgato, Jayne Murray, Lin Xiao, Denise M. T. Yu, Kimberley M. Hanssen, Federico M. Giorgi, Daniel R. Carter, Andrew J. Gifford, Emanuele Valli, Giorgio Milazzo, Alvin Kamili, Chelsea Mayoh, Bing Liu, Georgina Eden, Sara Sarraf, Sophie Allan, Simone Di Giacomo, Claudia L. Flemming, Amanda J. Russell, Belamy B. Cheung, Andre Oberthuer, Wendy B. London, Matthias Fischer, Toby N. Trahair, Jamie I. Fletcher, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Mark R. Burns, Giovanni Perini, Murray D. Norris, and Michelle Haber, Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma, «SCIENCE TRANSLATIONAL MEDICINE», 2019, 11, pp. 1 - 12 [Scientific article]

Wong M.; Sun Y.; Xi Z.; Milazzo G.; Poulos R.C.; Bartenhagen C.; Bell J.L.; Mayoh C.; Ho N.; Tee A.E.; Chen X.; Li Y.; Ciaccio R.; Liu P.Y.; Jiang C.C.; Lan Q.; Jayatilleke N.; Cheung B.B.; Haber M.; Norris M.D.; Zhang X.D.; Marshall G.M.; Wang J.Y.; Huttelmaier S.; Fischer M.; Wong J.W.H.; Xu H.; Perini G.; Dong Q.; George R.E.; Liu T., JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma, «NATURE COMMUNICATIONS», 2019, 10, pp. 1 - 15 [Scientific article]Open Access

Liu, Pei Y; Tee, Andrew E; Milazzo, Giorgio; Hannan, Katherine M; Maag, Jesper; Mondal, Sujanna; Atmadibrata, Bernard; Bartonicek, Nenad; Peng, Hui; Ho, Nicholas; Mayoh, Chelsea; Ciaccio, Roberto; Sun, Yuting; Henderson, Michelle J; Gao, Jixuan; Everaert, Celine; Hulme, Amy J; Wong, Matthew; Lan, Qing; Cheung, Belamy B; Shi, Leming; Wang, Jenny Y; Simon, Thorsten; Fischer, Matthias; Zhang, Xu D; Marshall, Glenn M; Norris, Murray D; Haber, Michelle; Vandesompele, Jo; Li, Jinyan; Mestdagh, Pieter; Hannan, Ross D; Dinger, Marcel E; Perini, Giovanni; Liu, Tao, The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35, «NATURE COMMUNICATIONS», 2019, 10, pp. 1 - 17 [Scientific article]Open Access

Ferrucci, Francesca; Ciaccio, Roberto; Monticelli, Sara; Pigini, Paolo; di Giacomo, Simone; Purgato, Stefania; Erriquez, Daniela; Bernardoni, Roberto; Norris, Murray; Haber, Michelle; Milazzo, Giorgio; Perini, Giovanni, MAX to MYCN intracellular ratio drives the aggressive phenotype and clinical outcome of high risk neuroblastoma, «BIOCHIMICA ET BIOPHYSICA ACTA», 2018, 1861, pp. 235 - 245 [Scientific article]

Agarwal, Saurabh; Milazzo, Giorgio; Rajapakshe, Kimal; Bernardi, Ronald; Chen, Zaowen; Barberi, Eveline; Koster, Jan; Perini, Giovanni; Coarfa, Cristian; Shohet, Jason M., MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma, «ONCOTARGET», 2018, 9, pp. 20323 - 20338 [Scientific article]

Macchia, Gemma; Severgnini, Marco; Purgato, Stefania; Tolomeo, Doron; Casciaro, Hilen; Cifola, Ingrid; L'Abbate, Alberto; Loverro, Anna; Palumbo, Orazio; Carella, Massimo; Bianchini, Laurence; Perini, Giovanni; De Bellis, Gianluca; Mertens, Fredrik; Rocchi, Mariano; Storlazzi, Clelia T, The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer, «GENETICS», 2018, 208, pp. 951 - 961 [Scientific article]

Tolomeo, Doron; Capozzi, Oronzo; Stanyon, Roscoe R.; Archidiacono, Nicoletta; D'Addabbo, Pietro; Catacchio, Claudia R.; Purgato, Stefania; Perini, Giovanni; Schempp, Werner; Huddleston, John; Malig, Maika; Eichler, Evan E.; Rocchi, Mariano, Epigenetic origin of evolutionary novel centromeres, «SCIENTIFIC REPORTS», 2017, 7, pp. 1 - 10 [Scientific article]

Wong, Matthew; Tee, Andrew E.L.; Milazzo, Giorgio; Bell, Jessica L.; Poulos, Rebecca C.; Atmadibrata, Bernard; Sun, Yuting; Jing, Duohui; Ho, Nicholas; Ling, Dora; Liu, Pei Yan; Zhang, Xu Dong; Hüttelmaier, Stefan; Wong, Jason W.H.; Wang, Jenny; Polly, Patsie; Perini, Giovanni; Scarlett, Christopher J.; Liu, Tao, The histone methyltransferase DOT1L promotes neuroblastoma by regulating gene transcription, «CANCER RESEARCH», 2017, 77, pp. 2522 - 2533 [Scientific article]

Gherardi, Samuele; Bovolenta, Matteo; Passarelli, Chiara; Falzarano, Maria Sofia; Pigini, Paolo; Scotton, Chiara; Neri, Marcella; Armaroli, Annarita; Osman, Hana; Selvatici, Rita; Gualandi, Francesca; Recchia, Alessandra; Mora, Marina; Bernasconi, Pia; Maggi, Lorenzo; Morandi, Lucia; Ferlini, Alessandra; Perini, Giovanni, Transcriptional and epigenetic analyses of the DMD locus reveal novel cis‑acting DNA elements that govern muscle dystrophin expression, «BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS», 2017, 1860, pp. 1138 - 1147 [Scientific article]