Foto del docente

Giovanni Perini

Professore ordinario

Dipartimento di Farmacia e Biotecnologie

Settore scientifico disciplinare: BIOS-14/A Genetica

Pubblicazioni

Murray, J. E.; Valli, E.; Milazzo, G.; Mayoh, C.; Gifford, A. J.; Fletcher, J. I.; Xue, C.; Jayatilleke, N.; Salehzadeh, F.; Gamble, L. D.; Rouaen, J. R. C.; Carter, D. R.; Forgham, H.; Sekyere, E. O.; Keating, J.; Eden, G.; Allan, S.; Alfred, S.; Kusuma, F. K.; Clark, A.; Webber, H.; Russell, A. J.; de Weck, A.; Kile, B. T.; Santulli, M.; De Rosa, P.; Fleuren, E. D. G.; Gao, W.; Wilkinson-White, L.; Low, J. K. K.; Mackay, J. P.; Marshall, G. M.; Hilton, D. J.; Giorgi, F. M.; Koster, J.; Perini, G.; Haber, M.; Norris, M. D., The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis, «NATURE COMMUNICATIONS», 2024, 15, pp. 1 - 21 [articolo]Open Access

De Rosa P.; Severi F.; Zadran S.K.; Russo M.; Aloisi S.; Rigamonti A.; Capranico G.; Milazzo G.; Perini G., MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitors’ Efficacy in Neuroblastoma Cells, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2023, 24, Article number: 24065408, pp. 5408 - 5424 [articolo]Open Access

Tao L.; Mohammad M.A.; Milazzo G.; Moreno-Smith M.; Patel T.D.; Zorman B.; Badachhape A.; Hernandez B.E.; Wolf A.B.; Zeng Z.; Foster J.H.; Aloisi S.; Sumazin P.; Zu Y.; Hicks J.; Ghaghada K.B.; Putluri N.; Perini G.; Coarfa C.; Barbieri E., MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma, «NATURE COMMUNICATIONS», 2022, 13, pp. 1 - 17 [articolo]Open Access

Milazzo G.; Perini G.; Giorgi F.M., Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells, «GENES», 2022, 13, pp. 2240 - 2254 [articolo]Open Access

Gamble L.D.; Purgato S.; Henderson M.J.; Di Giacomo S.; Russell A.J.; Pigini P.; Murray J.; Valli E.; Milazzo G.; Giorgi F.M.; Cowley M.; Ashton L.J.; Bhalshankar J.; Schleiermacher G.; Rihani A.; Van Maerken T.; Vandesompele J.; Speleman F.; Versteeg R.; Koster J.; Eggert A.; Noguera R.; Stallings R.L.; Tonini G.P.; Fong K.; Vaksman Z.; Diskin S.J.; Maris J.M.; London W.B.; Marshall G.M.; Ziegler D.S.; Hogarty M.D.; Perini G.; Norris M.D.; Haber M., A g316a polymorphism in the ornithine decarboxylase gene promoter modulates mycn‐driven childhood neuroblastoma, «CANCERS», 2021, 13, Article number: 1807, pp. 1807 - 1825 [articolo]Open Access

Tao L.; Moreno-Smith M.; Ibarra-Garcia-Padilla R.; Milazzo G.; Drolet N.A.; Hernandez B.E.; Oh Y.S.; Patel I.; Kim J.J.; Zorman B.; Patel T.; Kamal A.H.M.; Zhao Y.; Hicks J.; Vasudevan S.A.; Putluri N.; Coarfa C.; Sumazin P.; Perini G.; Parchem R.J.; Uribe R.A.; Barbieri E., CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming, «ADVANCED SCIENCE», 2021, 8, Article number: 2005047, pp. 1 - 22 [articolo]Open Access

Moreno-Smith M.; Milazzo G.; Tao L.; Fekry B.; Zhu B.; Mohammad M.A.; Di Giacomo S.; Borkar R.; Reddy K.R.K.; Capasso M.; Vasudevan S.A.; Sumazin P.; Hicks J.; Putluri N.; Perini G.; Eckel-Mahan K.; Burris T.P.; Barbieri E., Restoration of the molecular clock is tumor suppressive in neuroblastoma, «NATURE COMMUNICATIONS», 2021, 12, Article number: 4006, pp. 4006 - 4021 [articolo]Open Access

Mercatelli D.; Balboni N.; Palma A.; Aleo E.; Sanna P.P.; Perini G.; Giorgi F.M., Single-cell gene network analysis and transcriptional landscape of MYCN-amplified neuroblastoma cell lines, «BIOMOLECULES», 2021, 11, Article number: 177, pp. 1 - 18 [articolo]Open Access

Ciaccio R.; De Rosa P.; Aloisi S.; Viggiano M.; Cimadom L.; Zadran S.K.; Perini G.; Milazzo G., Targeting oncogenic transcriptional networks in neuroblastoma: From N-Myc to epigenetic drugs, «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES», 2021, 22, Article number: 12883, pp. 12883 - 12916 [articolo]Open Access

Milazzo G.; Mercatelli D.; Di Muzio G.; Triboli L.; De Rosa P.; Perini G.; Giorgi F.M., Histone deacetylases (HDACs): Evolution, specificity, role in transcriptional complexes, and pharmacological actionability, «GENES», 2020, 11, Article number: 556, pp. 1 - 49 [articolo]Open Access

Mzoughi, Slim; Fong, Jia Yi; Papadopoli, David; Koh, Cheryl M; Hulea, Laura; Pigini, Paolo; Di Tullio, Federico; Andreacchio, Giuseppe; Hoppe, Michal Marek; Wollmann, Heike; Low, Diana; Caldez, Matias J; Peng, Yanfen; Torre, Denis; Zhao, Julia N; Uchenunu, Oro; Varano, Gabriele; Motofeanu, Corina-Mihaela; Lakshmanan, Manikandan; Teo, Shun Xie; Wun, Cheng Mun; Perini, Giovanni; Tan, Soo Yong; Ong, Chee Bing; Al-Haddawi, Muthafar; Rajarethinam, Ravisankar; Hue, Susan Swee-Shan; Lim, Soon Thye; Ong, Choon Kiat; Huang, Dachuan; Ng, Siok-Bian; Bernstein, Emily; Hasson, Dan; Wee, Keng Boon; Kaldis, Philipp; Jeyasekharan, Anand; Dominguez-Sola, David; Topisirovic, Ivan; Guccione, Ernesto, PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis, «NATURE COMMUNICATIONS», 2020, 11, pp. 3520 - 3533 [articolo]Open Access

Bibbo' S.; Lamolinara A.; Capone E.; Purgato S.; Tsakaneli A.; Panella V.; Sallese M.; Rossi C.; Ciufici P.; Nieddu V.; De Laurenzi V.; Iezzi M.; Perini G.; Sala G.; Sala A., Repurposing a psychoactive drug for children with cancer: p27 Kip1-dependent inhibition of metastatic neuroblastomas by Prozac, «ONCOGENESIS», 2020, 9, pp. 1 - 8 [articolo]Open Access

Roberto Bernardoni, Giorgia Giordani, Elisabetta Signorino, Sara Monticelli, Francesca Messa, Monica Pradotto, Valentina Rosso, Enrico Bracco, Angela Giangrande, Giovanni Perini, Giuseppe Saglio, Daniela Cilloni, A new BCR-ABL1 Drosophila model as a powerful tool to elucidate pathogenesis and progression of chronic myeloid leukemia, «HAEMATOLOGICA», 2019, 104, pp. 717 - 728 [articolo]Open Access

Koach, Jessica; Holien, Jessica K; Massudi, Hassina; Carter, Daniel R; Ciampa, Olivia C; Herath, Mika; Lim, Taylor; Seneviratne, Janith A; Milazzo, Giorgio; Murray, Jayne E; McCarroll, Joshua A; Liu, Bing; Mayoh, Chelsea; Keenan, Bryce; Stevenson, Brendan W; Gorman, Michael A; Bell, Jessica L; Doughty, Larissa; Hüttelmaier, Stefan; Oberthuer, Andre; Fischer, Matthias; Gifford, Andrew J; Liu, Tao; Zhang, Xiaoling; Zhu, Shizhen; Gustafson, W Clay; Haber, Michelle; Norris, Murray D; Fletcher, Jamie I; Perini, Giovanni; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M, Drugging MYCN oncogenic signalling through the MYCN-PA2G4 binding interface, «CANCER RESEARCH», 2019, 79, pp. 5652 - 5667 [articolo]Open Access

Laura D. Gamble, Stefania Purgato, Jayne Murray, Lin Xiao, Denise M. T. Yu, Kimberley M. Hanssen, Federico M. Giorgi, Daniel R. Carter, Andrew J. Gifford, Emanuele Valli, Giorgio Milazzo, Alvin Kamili, Chelsea Mayoh, Bing Liu, Georgina Eden, Sara Sarraf, Sophie Allan, Simone Di Giacomo, Claudia L. Flemming, Amanda J. Russell, Belamy B. Cheung, Andre Oberthuer, Wendy B. London, Matthias Fischer, Toby N. Trahair, Jamie I. Fletcher, Glenn M. Marshall, David S. Ziegler, Michael D. Hogarty, Mark R. Burns, Giovanni Perini, Murray D. Norris, and Michelle Haber, Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma, «SCIENCE TRANSLATIONAL MEDICINE», 2019, 11, pp. 1 - 12 [articolo]

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