Dissertation topics suggested by the teacher.
Research line 1: Novel molecular strategies for cardiac regeneration
Heart dysfunction as a consequence of severe damages, such those induced by myocardial infarction, is a crucial public health problem and a leading cause of death in the western world today.
The aim of the studies carried out by our research group is to identify novel strategies for heart regeneration following severe damages, by direct stimulation of cell dedifferentiation, cell cycle re-entry and proliferation of endogenous cardiac muscle cells (cardiomyocytes).
This project involves the evaluation of differentiation status and proliferation of cardiomyocytes following the administration of specific stimuli (hormones, cytokines, growth factors...) or gene manipulation, and the analysis of the downstream molecular mechanisms.
Recent dissertations supervised by the teacher.
Second cycle degree programmes dissertations
- Analysis of the modulation of estrogen receptors on postnatal cardiomyocyte proliferative ability
- Characterization of heparin-starpeg hydrogel for bioprinting kidney cells
- Crosstalk between glucocorticoids and Neuregulin 1 in anthracyclines-induced cardiotoxicity
- Exploring combinatorial cardiac regenerative strategies based on small molecule inhibitors
- Exploring estradiol as a potential strategy to mend broken hearts: role and molecular mechanism in neonatal cardiomyocyte proliferation.
- Investigating maturational mechanisms of induced pluripotent stem cell-derived cardiomyocytes in 3-dimensional culture
- The impact of high doses of EGF on ERBB2-mediated phenotypes in breast cancer cells
- The impact of selective glucocorticoid receptor modulation on cardiomyocyte proliferation
- The role of ERBB2 in cellular senescence of breast epithelial cells: implications for cancer dormancy
PhD programmes thesis
- Dissecting the crosstalk between glucocorticoids and growth factors: implications for cardiac regenerative therapies
- ERBB and steroid hormone pathways in cell proliferation and differentiation
