GABRIELE D'UVA - SHORT CURRICULUM VITAE
Current position.
2023-present: Associate Professor of Molecular Biology (SSD BIO/11), Department of Medicine and Surgical Sciences (DIMEC), University of Bologna, Italy.
Personal data.
Born in Galatina (Lecce) in 1980.
Education.
2011: Ph.D. in “Biotechnology, Pharmacology and Toxicology” (University of Bologna, Italy).
2007: Master's Degree in Biotechnology (University of Bologna, Italy).
Past Positions.
2022: Associate Professor of Molecular Biology (SSD BIO/11) and Head of a Research Unit, Department of Specialist Diagnostic and Experimental Medicine (DIMES), University of Bologna, Italy.
2022: Researcher (RTD-b), Head of a Research Unit and lecturer in Molecular Biology (SSD BIO/11), Department of Specialist Diagnostic and Experimental Medicine (DIMES), University of Bologna, Italy.
2017-2019: Principal Investigator (Head of a Research Unit), IRCCS MultiMedica, Milan, Italy.
2016: Senior Researcher (Project Leader), IRCCS MultiMedica, Milan, Italy.
2012-2015: Post-doctoral researcher, Biological Regulation Dept., Weizmann Institute of Science, Israel.
2011: Post-doctoral researcher, Immunology Dept., Weizmann Institute of Science, Israel.
2009-2011: Visiting PhD student, Immunology Dept., Weizmann Institute of Science, Israel.
2008-2009: PhD student, CRBA, Sant'Orsola-Malpighi Hospital and University of Bologna, Italy.
2005-2007: Master student, CRBA, Sant'Orsola-Malpighi Hospital and University of Bologna, Italy.
Institutional, Organizational, and Service Activities.
023-present: Member of the Working Group supporting the research delegate (GdL Ricerca) of the Department of Medicine and Surgical Sciences (DIMEC) at the University of Bologna.
2023-present: Elected member of the Board (Associate Professors category) of the Department of Medicine and Surgical Sciences (DIMEC) at the University of Bologna.
2022-present: Member of the Teaching Staff of the Ph.D. Program in Surgical Sciences and Innovative Technologies, University of Bologna.
2021: Member of the Teaching Staff of the Ph.D. Program in Surgical Sciences, University of Bologna
2022: Member of the University Working Group on the scientific project of the Biomedical Tower.
2021-2022: Elected member of the Board (Researcher category) of the Department of Specialist Diagnostic, Experimental Medicine (DIMES) at the University of Bologna.
2018-present: President of "Ricercatori e scienziati Italiani all'Estero - RIE" Association.
2018-2019: Coordinator of scientific projects on "Cardiac regenerative medicine and cardiotoxicity" within the research line 1 (Cardiovascular diseases and pluripathological subject: physiopathology, translational research, and assistance) at IRCCS MultiMedica (Milan).
2017-2019: Director of Cardiac Regeneration laboratory, IRCCS MultiMedica, Milan, Italy.
Commissions of trust.
Member of the ERA-CVD Review Board of ERA-CVD Joint Transnational Call of the European Union's Horizon 2020 Framework Programme, External Expert of COST (European Cooperation in Science and Technology).
Scientific societies.
Member of "International Society for Heart Research" (ISHR), "Heart Failure Association” (HFA), "European Society of Cardiology" (ESC) and some of its Councils ("Council on Cardiovascular Genomics", “Council on Stroke”) and working groups ("WG on Development, Anatomy and Pathology", "WG on Cardiovascular Regenerative & Reparative Medicine", "WG on Cellular Biology of the Heart”, "WG on Myocardial Function").
Member of "Association of Cell Biology and Differentiation" (ABCD), "Società Italiana di Biochimica e Biologia Molecolare" (SIB), "Federation of European Biochemical Societies" (FEBS)
Editorial and reviewer activity.
Reviewer for peer-reviewed international journals in the fields of cardiovascular diseases, stem cells and cancer, including Journal of the National Cancer Institute (JNCI), Carcinogenesis, Stem cells, Frontiers in Cardiovascular Medicine, Frontiers in Physiology, Food and Chemical Toxicology, Histochemistry & Cytochemistry, Plos One.
Reviewer editor of “Frontiers in Cardiovascular Medicine” journal (“Cardiovascular Biologics and Regenerative Medicine” section).
Chief Editor of Bitnos, a collaborative web platform providing online biomedical tools and resources.
Teaching activity.
2019-present: Professor of Molecular Biology in Single cycle degree programme in Medicine and Surgery (Teaching activity in English), Medicine and Surgery (Teaching activity in Italian) and School of Dentistry (Teaching activity in Italian) of University of Bologna.
2019-present: Professor of the Elective Course "REGENERATIVE MEDICINE: UNFOLDING THE NANOWORLD OF STEM CELLS TOWARDS A SELF-HEALING POTENTIAL" (Teaching activity in English) in Second cycle degree programme in Medical Biotechnology and in Single cycle degree programme in Medicine and Surgery at University of Bologna.
Mentoring activity.
Supervision of research activities of postgraduate and postdoctoral researchers, PhD students and Master students.
Research support (competitive funding).
Competitive grants for research activity from various public and private bodies, including the European Union, the Ministry of Education and Research (PRIN calls, ...), AIRC, Fondazione CARISBO, Fondazione Luisa Fanti Melloni and Fondazione Cariplo.
Scientific interests and laboratory activity.
Current research interests are centred on regulatory molecular mechanisms governing stem/progenitor cell expansion and differentiation or mature cell dedifferentiation during physiological tissue renewal/regeneration and cancer development. Part of the research activities are focused on the cardiotoxic side effects of anticancer therapies.
Laboratory activities are also conducted in collaboration with IRCCS Sant'Orsola, the Interuniversity Consortium Institute of National Biostructures and Biosystems (INBB, Bologna), and the Center for Applied Biomedical Research (CRBA, Bologna).
Website: duvalab.com
Publications.
Publication of numerous papers in international peer-reviewed journals, including prestigious journals (Nature 2018; Nature Communications 2014; Nature Immunology 2012; Nature Immunology 2011). Discovered a crucial role for the ERBB2 tyrosine kinase receptor (Nature Cell Biology, 2015) and and the glucocorticoid receptor (GR) (Nature Cardiovascular Research, 2022) in heart development and regeneration, with significant scientific and media coverage.
Patents.
Co-inventor of a method to enhance cardiac regeneration with an agent that increases the activity or expression of ErbB2 along with neuregulin treatment (“Methods, kits and devices for promoting cardiac regeneration").
Seminars and meetings.
Keynote speaker in international conferences, including CardioCure (Innsbruck, Austria, 2019), Masterclass in Cardiac regeneration in translational research (Utrecht, The Netherlands, 2019), NCCR Meeting (Hamburg, Germany, 2016).
Invited speaker in international conferences, including STEMNET Meeting (Brescia, Italy, 2023), CNIC conference (Madrid, Spain, 2022), ERA-NET on Cardiovascular Diseases Symposium (Riga, Latvia, 2022 and 2019), ICAMP Congress (Milan, Italy, 2016), Heart Failure Association Winter Research Meeting (Les Diablerets, Switzerland, 2016), Congresso “Meccanismi, diagnosi e trattamento della tossicità cardiovascolare in oncologia” (Meldola, Italy, 2015).
Selected speaker in international conferences, including ABCD Congress 2019 (Bologna, Italy), ABCD Meeting 2018 (Pavia, Italy), CONGRESSO NAZIONALE SIC (Rome, Italy), ABCD Congress 2015 (Bologna, Italy), SIPMeT (Italian association of pathology and translational medicine) Young Scientist Meeting 2015 (Alba - CN, Italy), Keystone Symposia "Heart Disease and Regeneration: Insights from Development" (Colorado, USA), The 5th Young Investigators Stem Cell Meeting organized by Israeli Stem Cells Society - ISSC (Technion, Haifa, Israel), EMBO meeting “Cardiac Biology - From Development to Regenerative Medicine” (EMBL Heidelberg, Germany).
Invited seminars in Universities and Research Institutions, including the Department of Molecular Biotechnology and Health Sciences at University of Turin, Division of Genetics and Cell Biology at San Raffaele Hospital (Milan), IRCCS MultiMedica (Milan), Department of Cell Physiology and Metabolism at University of Geneva (Switzerland), FIRC Institute of Molecular Oncology - IFOM (Milan, Italy), National Institute of Molecular Genetics - INGM (Milan, Italy), Venetian Institute of Molecular Medicine - VIMM (Padova, Italy) and Department of Molecular Medicine at Sapienza University of Rome.
Poster presentation as senior author in international conferences, including XXIII International Society for Heart Research (ISHR) WORLD CONGRESS (Beijing, China), ERA-Net on Cardiovascular Diseases (ERA-CVD) Symposium" (Riga, Latvia), Heart Failure Association Winter Research Meeting - European Society of Cardiology (Les Diablerets, Switzerland), ACC 2018 "NEW TECHNOLOGIES AND STRATEGIES TO FIGHT CANCER" (San Raffaele Hospital, Milan, Italy), Nature Conference: Regeneration (San Raffaele Hospital, Milan, Italy), ABCD Meeting 2017 (Bologna, Italy), Annual meeting of the Working Groups on “Myocardial Function” and “Cellular Biology of the Heart” of European Society of Cardiology (Villa Monastero, Varenna, Italy), 4th INTERNATIONAL CONFERENCE TRANSLATIONAL RESEARCH IN ONCOLOGY (Forlì, Italy).
Honours and awards.
National and international media coverage, including articles in Il Resto del Carlino, Le Scienze, SkyTG24, La Repubblica, Sky News, and TV/radio interviews on RAI channels for the last-authored scientific article entitled "Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration" (Pianca, Sacchi [...] D’Uva, Nature Cardiovascular Research, 2022).
Commentary article in Nature Reviews Cardiology for the last-authored scientific article entitled "Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration" (Pianca, Sacchi [...] D’Uva, Nature Cardiovascular Research, 2022).
Commentary articles in prestigious scientific journals (Nature, Nature Drug Discovery and Science) for the first-authored scientific article “D’Uva [...] and Tzahor, Nature Cell Biology, 2015”.
International media coverage (including The Guardian, The Times of Israel and RAINEWS) for the scientific article “D’Uva [...] and Tzahor, Nature Cell Biology, 2015”.
International media coverage (including TIME, Daily Mail and Huffington Post) for the scientific article “Lauriola [...] D'Uva [...] and Yarden, Nature Communications, 2012”.
Journal cover and commentary article in Nature Immunology (May 2011) for the scientific article “Schajnovitz [...] D'Uva [...] and Lapidot, Nature Immunology, 2012”.
Research fellowships, including the Feinberg Postdoctoral Fellowship, Sergio Lombroso fellowship, Marco Polo fellowship...
Public engagement.
Dissemination of science for the general public by writing lay articles (Sanità al futuro 2019, Sanità al futuro 2019) and by participating as a guest in public events (LEbiotech 2020, Conversazioni sul futuro 2018).
