Foto del docente

Gabriele Matteo D'Uva

Associate Professor

Department of Experimental, Diagnostic and Specialty Medicine - DIMES

Academic discipline: BIO/11 Molecular Biology

Curriculum vitae

GABRIELE D'UVA - SHORT CURRICULUM VITAE

Current position.

2019-present: Researcher / Assistant Professor of Molecular Biology (RTD-b), Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Italy. 

Personal data.

Born in Galatina (Lecce) in 1980. 

Education.

2011: Ph.D. in “Biotechnology, Pharmacology and Toxicology” (University of Bologna, Italy).

2007: Master's Degree in Biotechnology (University of Bologna, Italy).

Past Positions.

2017-2019: Group Leader, IRCCS MultiMedica, Milan, Italy.

2016: Researcher, IRCCS MultiMedica, Milan, Italy.

2012-2015: Post-doctoral researcher, Biological Regulation Dept., Weizmann Institute of Science, Israel.

2011: Post-doctoral researcher, Immunology Dept., Weizmann Institute of Science, Israel.

2009-2011: Visiting PhD student, Immunology Dept., Weizmann Institute of Science, Israel.

2008-2009: PhD student, CRBA, Sant'Orsola-Malpighi Hospital and University of Bologna, Italy.

2005-2007: Master student, CRBA, Sant'Orsola-Malpighi Hospital and University of Bologna, Italy.

Managerial responsibilities.

2021-present: Member of the Board of Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna

2021-present: Member of the academic board of the PhD Program in Surgical Sciences and Innovatives  Technologies, University of Bologna

2018-present: President of "Ricercatori e scienziati Italiani all'Estero - RIE [https://ricercatoriestero.org/] " Association.

2018-2019: Head of "Regenerative medicine and cardiotoxicity" Research Activities, IRCCS MultiMedica, Milan, Italy.

2017-2019: Director of Cardiac Regeneration laboratory, IRCCS MultiMedica, Milan, Italy.

Commissions of trust.

Member of the ERA-CVD Review Board of ERA-CVD Joint Transnational Call of the European Union's Horizon 2020 Framework Programme, External Expert of COST (European Cooperation in Science and Technology).

Scientific societies.

Member of "International Society for Heart Research" (ISHR), "Heart Failure Association” (HFA), "European Society of Cardiology" (ESC) and some of its Councils ("Council on Cardiovascular Genomics", “Council on Stroke”) and working groups ("WG on Development, Anatomy and Pathology", "WG on Cardiovascular Regenerative & Reparative Medicine", "WG on Cellular Biology of the Heart”, "WG on Myocardial Function").

Member of "Association of Cell Biology and Differentiation" (ABCD), "Società Italiana di Biochimica e Biologia Molecolare" (SIB), "Federation of European Biochemical Societies" (FEBS)

Editorial and reviewer activity.

Reviewer for peer-reviewed international journals in the fields of cardiovascular diseases, stem cells and cancer, including Journal of the National Cancer Institute (JNCI), Carcinogenesis, Stem cells, Frontiers in Cardiovascular Medicine, Frontiers in Physiology, Food and Chemical Toxicology, Histochemistry & Cytochemistry, Plos One.

Reviewer editor of “Frontiers in Cardiovascular Medicine” journal (“Cardiovascular Biologics and Regenerative Medicine” section).

Chief Editor of Bitnos, a collaborative web platform providing online biomedical tools and resources.

Teaching activity.

2019-present: Professor of Molecular Biology in Single cycle degree programme in Medicine and Surgery (Teaching activity in English), Medicine and Surgery (Teaching activity in Italian) and School of Dentistry (Teaching activity in Italian) of University of Bologna.

2019-present: Teacher of the Elective Course "REGENERATIVE MEDICINE: UNFOLDING THE NANOWORLD OF STEM CELLS TOWARDS A SELF-HEALING POTENTIAL" (Teaching activity in English) in Second cycle degree programme in Medical Biotechnology and in Single cycle degree programme in Medicine and Surgery at University of Bologna.

Mentoring activity.

Supervision of research activities of postgraduate and postdoctoral researchers, PhD students and Master students.

Research support (competitive funding).

He has obtained competitive grants for his research activity from various public and private bodies, including the European Union, AIRC, Fondazione CARISBO, Fondazione Luisa Fanti Melloni and Fondazione Cariplo.

Scientific interests and laboratory activity.

His current research interests are centred on regulatory molecular mechanisms governing stem/progenitor cell expansion and differentiation or mature cell dedifferentiation during physiological tissue renewal/regeneration and cancer development. Part of the research activities are focused on the cardiotoxic side effects of anticancer therapies. He recently uncovered a crucial role for the tyrosine kinase receptor ERBB2 and glucocorticoid receptor (GR) in cardiac development and regeneration.

Laboratory activities are performed at the Centre for Applied Biomedical Research (CRBA, Bologna) and in collaboration with the Interuniversity Consortium Biostructures and Biosystems National Institute (INBB, Bologna) and IRCCS MultiMedica (Milan).

Website: duvalab.com 

Publications.

He has published more than 20 publications in peer-reviewed international journals, including prestigious journals (Nature 2018; Nature Communications 2014; Nature Immunology 2012; Nature Immunology 2011). He uncovered a key role for ERBB2 co-receptor in cardiac regeneration (Nature Cell Biology, 2015), which has had a significant scientific and mass-media coverage.

Patents.

He is co-inventor of a method of potentiating cardiac regeneration with an agent which upregulates activity or expression of ErbB-2 along with neuregulin treatment (“Methods, kits and devices for promoting cardiac regeneration").

Seminars and meetings.

Keynote speaker in international conferences, including CardioCure (Innsbruck, Austria, 2019), Masterclass in Cardiac regeneration in translational research (Utrecht, The Netherlands), NCCR Meeting (Hamburg, Germany, 2016).

Invited speaker in international conferences, including ERA-NET on Cardiovascular Diseases Symposium (Latvia), ICAMP Congress (Milan), Heart Failure Association Winter Research Meeting (Switzerland), Congresso “Meccanismi, diagnosi e trattamento della tossicità cardiovascolare in oncologia” (Meldola, Italy, 2015).

Selected speaker in international conferences, including ABCD Congress 2019 (Bologna, Italy), ABCD Meeting 2018 (Pavia, Italy), CONGRESSO NAZIONALE SIC (Rome, Italy), ABCD Congress 2015 (Bologna, Italy), SIPMeT (Italian association of pathology and translational medicine) Young Scientist Meeting 2015 (Alba - CN, Italy), Keystone Symposia "Heart Disease and Regeneration: Insights from Development" (Colorado, USA), The 5th Young Investigators Stem Cell Meeting organized by Israeli Stem Cells Society - ISSC (Technion, Haifa, Israel), EMBO meeting “Cardiac Biology - From Development to Regenerative Medicine” (EMBL Heidelberg, Germany).

Invited seminars in Universities and Research Institutions, including the Department of Molecular Biotechnology and Health Sciences at University of Turin, Division of Genetics and Cell Biology at San Raffaele Hospital (Milan), IRCCS MultiMedica (Milan), Department of Cell Physiology and Metabolism at University of Geneva (Switzerland), FIRC Institute of Molecular Oncology - IFOM (Milan, Italy), National Institute of Molecular Genetics - INGM (Milan, Italy), Venetian Institute of Molecular Medicine - VIMM (Padova, Italy) and Department of Molecular Medicine at Sapienza University of Rome.

Poster presentation as senior author in international conferences, including XXIII International Society for Heart Research (ISHR) WORLD CONGRESS (Beijing, China), ERA-Net on Cardiovascular Diseases (ERA-CVD) Symposium" (Riga, Latvia), Heart Failure Association Winter Research Meeting - European Society of Cardiology (Les Diablerets, Switzerland), ACC 2018 "NEW TECHNOLOGIES AND STRATEGIES TO FIGHT CANCER" (San Raffaele Hospital, Milan, Italy), Nature Conference: Regeneration (San Raffaele Hospital, Milan, Italy), ABCD Meeting 2017 (Bologna, Italy), Annual meeting of the Working Groups on “Myocardial Function” and “Cellular Biology of the Heart” of European Society of Cardiology (Villa Monastero, Varenna, Italy), 4th INTERNATIONAL CONFERENCE TRANSLATIONAL RESEARCH IN ONCOLOGY (Forlì, Italy).

Honours and awards.

Commentary articles for the scientific article “D’Uva et al, Nature Cell Biology, 2015” in Nature, Nature Drug Discovery and Science.

International media coverage (including The Guardian, The Times of Israel and RAINEWS) for the scientific article “D’Uva et al., Nature Cell Biology, 2015”.

International media coverage (including TIME, Daily Mail and Huffington Post) for the scientific article “Lauriola et al., Nature Communications, 2012”.

Journal cover and commentary article in Nature Immunology (May 2011) for the scientific article “Schajnovitz et al., Nature Immunology, 2012”.

Research fellowships, including the Feinberg Postdoctoral Fellowship, Sergio Lombroso fellowship, Marco Polo fellowship...

Public engagement.

Dissemination of science for the general public by writing lay articles (Sanità al futuro 2019, Sanità al futuro 2019) and by participating as a guest in public events (LEbiotech 2020, Conversazioni sul futuro 2018).

Latest news

At the moment no news are available.