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Chiara La Morgia

Senior assistant professor (fixed-term)

Department of Biomedical and Neuromotor Sciences

Academic discipline: MED/26 Neurology

Curriculum vitae

Personal data:

  • Date of birth: 3rd December 1977, Lanciano (CH), Italy
  • Nationality: Italian
  • Fiscal code: LMRCHR77T43E435I
  • Affiliations:
  • IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica,

    Ospedale Bellaria, Via Altura 3, Bologna (BO)

  • Dipartimento di Scienze Biomediche e NeuroMotorie (DIBINEM)

Università di Bologna, Via Ugo Foscolo 7, 40123, Bologna

  • e-mail: chiaralamorgia@gmail.com; chiara.lamorgia@unibo.it [mailto:chiara.lamorgia@unibo.it]
  • “Ordine dei Medici di Bologna”, number 1472 since 2002
Education and training:
  • 1996: High school degree, Liceo Classico “Vittorio Emanuele II”, 1996, final mark 60/60
  • 2002: MD degree, University of Bologna, Italy. Final mark: 110/110 cum laudae. Thesis: “Neurological complications in bone marrow transplantation”
  • 2003-2008: Residency in Neurology, Department of Neurological Sciences, University of Bologna, Italy. Final mark: 70/70 cum laudae. Thesis: “Circadian photoreception in hereditary optic neuropathies”
  • 2009-2012: PhD in Sleep Medicine, Department of Neurological Sciences, University of Bologna, Italy. Thesis: “Melanopsin retinal ganglion cells: relevance to circadian rhythms and sleep in neurodegeneration”
  • April 2014-September 2014: clinical fellowship in Neurophthalmology at the Doheny Eye Institute, University of Southern California (USC), now University of California Los Angeles (UCLA), Los Angeles, California, USA

    Research experience:

  • November 2005: granted as “Expert in Sleep Medicine” by the Italian Association of Sleep Medicine (AIMS)
  • 2008-now: research fellowship at Doheny Eye Institute, University of Southern California, Los Angeles (California, USA) for collaborative project on “Neurodegenerative disorders and circadian photoreception” with attendance periods January 25th-February 9th 2008; August 23th-September 13th 2008; February 19th- March 4th 2009; February 21st-March 13th 2010; August 20th-September 10th 2010; August 28th-September 12th 2011; February 15th-March 2nd 2012; July 17th-August 5th 2013; May 10th-May 25th 2013; March 24th-October 3rd 2014)
  • 2010-now: member of the international team ‘Projeto LHON/Brazil’ for the study of a LHON Brazilian family with a project on “Melanopsin retinal ganglion cells and pupillary reflex in Leber’s hereditary optic neuropathy patietns”
  • 2006-2010: component of the research team on “Telethon project GGP06233”, titled: “Pathogenic mechanism for degeneration of retinal ganglion cells in mitochondrial optic neuropathies”
  • 2010-now: component of the research team on “Telethon project, Program Project 2010”, titled “Therapeutic strategies to combat mitochondrial disorders”
  • 2010-now: component of the research project titled “Identification of predictive factors for conversion from mild cognitive impairment to dementia” (Fondazione Gino Galletti, Italy)
  • 2012-dec2017: Emilia-Romagna region Program Project "Recognition, diagnosis and therapy of mitochondrial disorders in neurological services of the Emilia-Romagna region" (grant ER-MITO)
  • January 2012-september 2015: research fellowship, project titled: “Function of melanopsin expressing retinal ganglion cells in neurological disorders and aging” Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Italy
  • 2013-now: member of the Committee “Sleep and Neurodegenerative Disorders”, Italian Sleep Society (AIMS)
  • 2015-now: collaborative project with the Neurosurgery Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna on “Study of the predictive role of OCT in the visual outcome of patients with pituitary adenoma”
  • 2015-now: collaborative project with fMRI Unit, S.Orsola-Malpighi Hospital on “fMRI study on cerebral responses to light stimulation in patients with Leber’s Hereditary Optic Neuropathy’
  • March 2017-now participation to a multicentric study titled “Multicentric study of the rest-activity genes and mitochondrial haplogroups in patients with mild-moderate Alzheimer’s disease and Mild Cognitive Impairment”, Coordinator Unit: Azienda Ospedaliero-Universitaria Pisana, UOC Neurologia, dr.ssa Enrica Bonanni
  • September 2015: research project titled “Melanopsin retinal ganglion cells and circadian rhythms: function and dysfunction in Alzheimer's disease and aging”– GR-2013-02358026 funded by the Italian Ministry of Health
  • Co-PI in the research project GR-2016-02361449 “Italian Project on Hereditary Optic Neropathies (IPHON): from genetic basis to therapy” funded by the Italian Ministry of Health

    Professional experience:

  • 2009-2012: clinical activity at the Neurologic Clinic Unit, Department of Neurological Sciences, University of Bologna (Day-Hospital, outpatient clinic and clinical ward)
  • 2013-now: clinical activity at the Unit of Neurology, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy
  • July 2011-May 2013: contract at the Department of Neurological Sciences, University of Bologna for the clinical trial sponsored by Sigma-Tau “Effects of l-acetylcarnitine on optic pathways neural conduction in Leber’s hereditary Optic neuropathy patients”
  • October 2013-March 2014: contract at the USL Bologna on a project on “Prevention of road accidents during working hours”
  • October 2015-now: Assistant Professor at the University of Bologna and clinical medical staff at the IRCCS Istituto delle Scienze Neurologiche di Bologna, Ospedale Bellaria, Bologna, Italy
  • May 2016-now: study coordinator and investigator of 2 phase III clinical trials on gene therapy in LHON patients
  • July 2016-now: investigator in the phase IV clinical trial on idebenone in LHON
  • Associate Professor in Neurology approval (valid from 28/03/2017 to 28/03/2023)

INTERNATIONAL COLLABORATIONS:

Professor Sadun Alfredo, Ophthalmology Unit, Doheny Eye Institute, University of Southern California, Los Angeles (California, USA)

Professor Jens Hannibal, University of Copenaghen, Department of Clinical Biochemistry, Bispebjerg Hospital and Righopitalet

AWARDS:

  • “Progetto Giovani”, 2005, 2006, 2007, 2008, 2009, 2010 and 2012 granted by Italian Neurological Society
  • “Progetto Giovani”, 2007 granted by Italian League against epilepsy
  • Award for the best poster, Società Italiana di Neurologia, 2007, abstract titled: “Rare mtDNA variants in Leber’s hereditary optic neuropathy families with recurrence of myoclonus”
  • Award for the best paper presentation, ‘Annual Meeting of the Italian Society of Neuropathology, 2009, abstract entitled “Melanopsin containing retinal ganglion cells are partially spared by neurodegeneration in Leber’s hereditary optic neuropathy”
  • Award for the best poster, XI Congress of the European Biological Rhythms Society, 2009, Strasbourg, France, abstract entitled “Circadian Photoreception in Mitochondrial Optic Neuropathies: relative sparing of Melanopsin-Containing Retinal Ganglion Cells”
  • Award “Franco Michele Puca” for the best contribution of a young scientist, XIX AIMS meeting, Bologna November 15-18th 2009, paper titled: “Circadian photoreception in hereditary optic neuropathies”
  • Travel grant for the Association for Research in Vision and Ophthalmology (ARVO) meeting, 2-6th may 2010, Fort Lauderdale, Miami
  • Award for the best oral presentation at the XLV Congresso AINP e XXXV AIRIC, Bologna, 3-6 Giugno 2010, with the paper “Melanopsin containing retinal ganglion cells are partially spared by neurodegeneration in Leber’s hereditary optic neuropathy”
  • International Scholarship Award for the paper titled: “Idebenone treatment in Leber’s hereditary optic neuropathy” at the 63rd AAN annual meeting, Hawaii, 9th-16th April 2011
  • “Stockgrand Travel Award Grant”, XII Congress of European Biological Rhythms Society Meeting”, Oxford, 20-26th August 2011
  • Award at the young investigator symposium “New tendencies in sleep medicine”, XXI Congresso Nazionale AIMS, Pavia, October 2-5th 2011
  • Selected by “Magnifico Rettore” (Prof. Ivano Dionigi) of the University of Bologna for a speech at the opening ceremony, Academic Year 2012-2013
  • “Marco Polo Programme” grant winner supporting a 6-months period in the USA with a research project on “Melanopsin retinal ganglion cells in neurodegenerative disorders and aging”, march 2014-september 2014

List of publications:

h-index:25

  1. La Morgia C, Mondini S, Guarino M, Bonifazi F, Cirignotta F. “Busulfan neurotoxicity: a case report”. Neurol Sci 2004; 25(2):95-97. [IF 2004: 1.059]
  2. Barboni P, Savini G, Valentino ML, La Morgia C, Bellusci C, De Negri AM, Sadun F, Carta A, Carbonelli M, Sadun A, and Carelli V. Leber's hereditary optic neuropathy with childhood onset. Invest Ophthalmol Vis Sci 2006;47(12):5303-5309. [IF 2006: 3.766]
  3. Vetrugno R, La Morgia C, D'Angelo R, Loi D, Provini F, Plazzi G, Montagna P. Augmentation of restless legs syndrome with long-term tramadol treatment. Mov Disord 2007;22(3):424-427. [IF 2007: 3.207]
  4. Carelli V, Franceschini F, Venturi S, Barboni P, Savini G, Barbieri G, Pirro E, La Morgia C, Valentino ML, Zanardi F, Violante FS, Mattioli S. Grand Rounds: Could Occupational Exposure to n-Hexane and Other Solvents Precipitate Visual Failure in Leber Hereditary Optic Neuropathy? Environ Health Perspect 2007;115(1):113-115. [IF 2007: 5.636]
  5. Carelli V, La Morgia C, Iommarini L, Carroccia R, Mattiazzi M, Sangiorgi S, Farnè S, Maresca A, Foscarini B, Lanzi L, Amadori M, Bellan M, Valentino ML. Mitochondrial optic neuropathies: how two genomes may kill the same cell type? Biosci Rep 2007;27(1-3):173-184. [IF 2007: 3.115]
  6. Hudson G, Carelli V, Spruijt L, Gerards M, Mowbray C, Achilli A, Pyle A, Elson J, Howell N, La Morgia C, Valentino ML, Huoponen K, Savontaus ML, Nikoskelainen E, Sadun AA, Salomao SR, Belfort R Jr, Griffiths P, Man PY, de Coo RF, Horvath R,Zeviani M, Smeets HJ, Torroni A, Chinnery PF. Clinical expression of Leber hereditary optic neuropathy is affected by the mitochondrial DNA-haplogroup background. Am J Hum Genet 2007;81(2):228-233. [IF 2007: 11.092]
  7. Amati-Bonneau P, Valentino ML, Reynier P, Gallardo ME, Bornstein B, BoissièreA, Campos Y, Rivera H, de la Aleja JG, Carroccia R, Iommarini L, Labauge P, Figarella-Branger D, Marcorelles P, Furby A, Beauvais K, Letournel F, Liguori R, La Morgia C, Montagna P, Liguori M, Zanna C, Rugolo M, Cossarizza A, Wissinger B, Verny C, Schwarzenbacher R, Martín MA, Arenas J, Ayuso C, Garesse R, Lenaers G, Bonneau D, Carelli V. OPA1 mutations induce mitochondrial DNA instability and optic atrophy 'plus' phenotypes. Brain 2008;131(Pt 2):338-351. [IF 2008: 9.603]
  8. La Morgia C, Achilli A, Iommarini L, Barboni P, Pala M, Olivieri A, Zanna C, Vidoni S, Tonon C, Lodi R, Vetrugno R, Mostacci B, Liguori R, Carroccia R, Montagna P, Rugolo M, Torroni A, Carelli V. Rare mtDNA variants in Leber hereditary optic neuropathy families with recurrence of myoclonus. Neurology 2008;70(10):762-770. [IF 2008: 7.043]
  9. La Morgia C, Parchi P, Capellari S, Lodi R, Tonon C, Rinaldi R, Mondini S, Cirignotta F 'Agrypnia excitata' in a case of sporadic Creutzfeldt-Jakob disease VV2. J Neurol Neurosurg Psychiatry 2009;80(2):244-6. [IF 2009: 4.869]
  10. Carelli V, La Morgia C, Valentino ML, Barboni P, Ross-Cisneros FN, Sadun AA. Retinal ganglion cells neurodegeneration in mitochondrial inherited disorders. Biochim Biophys Acta 2009;1787(5):518-28. [IF 2009: 3.688]
  11. Vetrugno R, Valentino ML, La Morgia C, Liguori R, Stecchi S, Mascalchi M, Fabbri M, Montagna P, Carelli V. Sleep-related periodic respiration with central sleep apnea in Leber Hereditary Optic Neuropathy (LHON). Sleep Med 2010;11(4):426-7. [IF 2011: 3.430]
  12. Cevoli S, Pallotti F, La Morgia C, Valentino ML, Pierangeli G, Cortelli P, Baruzzi A, Montagna P, Carelli V. High frequency of migraine-only patients negative for the 3243 A>G tRNALeu mtDNA mutation in two MELAS families. Cephalalgia 2010;30(8):919-27. [IF 2010: 4.265]
  13. La Morgia C, Ross-Cisneros FN, Sadun AA, Hannibal J, Munarini A, Mantovani V, Barboni P, Cantalupo G, Tozer KR, Sancisi E, Salomao SR, Moraes MN, Moraes-Filho MN, Heegaard S, Milea D, Kjer P, Montagna P, Carelli V. Melanopsin retinal ganglion cells are resistant to neurodegeneration in mitochondrial optic neuropathies. Brain 2010;133(Pt 8):2426-38. [IF 2010: 9.232]
  14. La Morgia C, Ross-Cisneros FN, Hannibal J, Montagna P, Sadun AA, Carelli V. Melanopsin-expressing retinal ganglion cells: implications for human diseases. Vision Res 2011 Jan 28;51(2):296-302. [IF 2011: 2.414]
  15. Lodi R, Tonon C, Valentino ML, Manners D, Testa C, Malucelli E, La Morgia C, Barboni P, Carbonelli M, Schimpf S, Wissinger B, Zeviani M, Baruzzi A, Liguori R, Barbiroli B, Carelli V. Defective Mitochondrial Adenosine Triphosphate Production in Skeletal Muscle From Patients With Dominant Optic Atrophy Due to OPA1 Mutations. Arch Neurol 2011 Jan;68(1):67-73. [IF 2011: 7.584]
  16. Sadun AA, La Morgia C, Carelli V. Leber's Hereditary Optic Neuropathy. Curr Treat Options Neurol 2011 Feb;13(1):109-17. [IF 2011: 1.292]
  17. Bonazza S, La Morgia C, Martinelli P, Capellari S. Strio-pallido-dentate calcinosis: a diagnostic approach in adult patients. Neurol Sci 2011 Aug;32(4):537-45. [IF 2011: 1.315]
  18. Barboni P, Savini G, Parisi V, Carbonelli M, La Morgia C, Maresca A, Sadun F, De Negri AM, Carta A, Sadun AA, Carelli V. Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy Measurements by Optical Coherence Tomography and Correlation with Age. Ophthalmology 2011 Oct;118(10):2076-80 [IF 2011: 5.454]
  19. Licchetta L, Bisulli F, Di Vito L, La Morgia C, Naldi I, Volta U, Tinuper P. Epilepsy in coeliac disease: not just a matter of calcifications. Neurol Sci 2011 Dec;32(6):1069-74 [IF 2011: 1.315]
  20. Carelli V, La Morgia C, Valentino ML, Rizzo G, Carbonelli M, De Negri AM, Sadun F, Carta A, Guerriero S, Simonelli F, Sadun AA, Aggarwal D, Liguori R, Avoni P, Baruzzi A, Zeviani M, Montagna P, Barboni P. Idebenone Treatment In Leber's Hereditary Optic Neuropathy. Brain 2011 Sep;134(Pt 9):e188 [IF 2011:9.457]
  21. La Morgia C, Barboni P, Rizzo G, Carbonelli M, Savini G, Scaglione C, Capellari S, Bonazza S, Giannoccaro MP, Calandra-Buonaura G, Liguori R, Cortelli P, Martinelli P, Baruzzi A, Carelli V. Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern? Eur J Neurol 2013, 20: 198–201 [IF 2013: 3.692]
  22. Achilli A, Iommarini L, Olivieri A, Pala M, Hooshiar Kashani B, Reynier P, La Morgia C, Valentino ML, Liguori R, Pizza F, Barboni P, Sadun F, De Negri AM, Zeviani M, Dollfus H, Moulignier A, Ducos G, Orssaud C, Bonneau D, Procaccio V, Leo-Kottler B, Fauser S, Wissinger B, Amati-Bonneau P, Torroni A, Carelli V. Rare primary mitochondrial DNA mutations and probable synergistic variants in Leber's hereditary optic neuropathy. PLoS One 2012;7(8):e42242. [IF 2011: 3.730]
  23. Maresca A, La Morgia C, Caporali L, Valentino ML, Carelli V. The optic nerve: A "mito-window" on mitochondrial neurodegeneration. Mol Cell Neurosci 2013 Jul;55:62-76 [IF 2013: 3.734]
  24. Rizzo G, Tozer KR, Tonon C, Manners D, Testa C, Malucelli E, Valentino ML, La Morgia C, Barboni P, Randhawa RS, Ross-Cisneros FN, Sadun AA, Carelli V, Lodi R. Secondary Post-Geniculate Involvement in Leber's Hereditary Optic Neuropathy. PLoS One 2012;7(11):e50230. [IF 2012: 3.730]
  25. Sadun AA, La Morgia C, Carelli V. Leber’s hereditary optic neuropathy: new quinone therapies change the paradigm. Expert Rev Ophthalmol 2012; 7(3): 251–259
  26. Caporali L, Ghelli AM, Iommarini L, Maresca A, Valentino ML, La Morgia C, Liguori R, Zanna C, Barboni P, De Nardo V, Martinuzzi A, Rizzo G, Tonon C, Lodi R, Calvaruso MA, Cappelletti M, Porcelli AM, Achilli A, Pala M, Torroni A, Carelli V. Cybrid studies establish the causal link between the mtDNA m.3890G>A/MT-ND1 mutation and optic atrophy with bilateral brainstem lesions. Biochim Biophys Acta 2013 Mar; 1832 (3):445-52. [IF 2013: 5.089]
  27. Carelli V, La Morgia C, Sadun AA. Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic options. Curr Opin Neurol 2013 Feb; 26 (1):52–58 [IF 2013: 5.729]
  28. Barboni P, Valentino ML, La Morgia C, Carbonelli M, Savini G, De Negri A, Simonelli F, Sadun F, Caporali L, Maresca A, Liguori R, Baruzzi A, Zeviani M and Carelli V. Idebenone treatment in patients with OPA1-mutant dominant optic atrophy. Brain 2013 Feb;136(Pt 2):e231. [IF 2013: 10.226]
  29. Barboni P, Carelli V, Savini G, Carbonelli M, La Morgia C, Sadun AA. Microcystic macular degeneration from optic neuropathy: not inflammatory, not trans-synaptic degeneration. Brain 2013 Jul;136(Pt 7):e239. [IF 2013: 10.226]
  30. Sadun AA, La Morgia C, Carelli V. Mitochondrial optic neuropathies: our travels from bench to bedside and back again An expansion of the 35(th) Susan Alper Memorial lecture by Alfredo A. Sadun, MD, PhD given at the Washington Hospital Medical Center on April 28, 2012. Clin Experiment Ophthalmol 2013 Sep-Oct; 41(7):702-712 [IF 2013:1.953]
  31. Moura AL, Nagy BV, La Morgia C, Barboni P, Oliveira AG, Salomão SR, Berezovsky A, de Moraes-Filho MN, Chicani CF, Belfort R Jr, Carelli V, Sadun AA, Hood DC, Ventura DF. The Pupil Light Reflex in Leber's Hereditary Optic Neuropathy: Evidence for Preservation of Melanopsin-Expressing Retinal Ganglion Cells. Invest Ophthalmol Vis Sci 2013 Jul 2;54(7):4471-7. [IF 2013: 3.661]
  32. Sadun AA, La Morgia C, Carelli V. Mitochondrial optic neuropathies: additional facts and concepts - response. Clin Experiment Ophthalmol 2014 Mar; 42(2):207-8 [IF 2014:2.347]
  33. Ziccardi L, Sadun F, De Negri AM, Barboni P,5, Savini G, Borrelli E, La Morgia C, Carelli V, Parisi V. Retinal function and neural conduction along the visual pathways in affected and unaffected carriers with Leber’s hereditary optic neuropathy. Invest Ophthalmol Vis Sci 2013, Oct 21;54(10):6893-901 [IF 2013: 3.661]
  34. Guaraldi P, Sancisi E, La Morgia C, Calandra-Buonaura G, Carelli V, Cameli O, Battistini A, Cortelli P, Piperno R. Nocturnal melatonin regulation in post-traumatic vegetative state: a possible role for melatonin supplementation? Chronobiol International 2014 Jun;31(5):741-5 [IF 2014: 3.343]
  35. Kaveh Moghadam K, Pizza F, Tonon C, Lodi R, Carelli V, Poli F, Franceschini C, Barboni P, Seri M, Ferrari S, La Morgia C, Testa C, Cornelio F, Liguori R, Winkelmann J, Lin L, Mignot E, Plazzi G. Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1. Sleep Medicine 2014 May; 15(5):582-5 [IF 2014: 3.154]
  36. Kaveh Moghadam K, Pizza F, La Morgia C, Franceschini C, Tonon C, Lodi R, Barboni P, Seri M, Ferrari S, Liguori R, Donadio V, Parchi P, Cornelio F, Inzitari D, Mignarri A, Capocchi G, Dotti MT, Winkelmann J, Lin L, Mignot E, Carelli V, Plazzi G. Narcolepsy is a common phenotype in both HSAN IE and ADCA-DN. Brain 2014 Jun; 137(Pt 6):1634-55 [IF 2014: 9.196]
  37. Carossa V, Ghelli A, Tropeano CV, Valentino ML, Iommarini L, Maresca A, Caporali L, La Morgia C, Liguori R, Barboni P, Carbonelli M, Rizzo G, Tonon C, Lodi R, Martinuzzi A, De Nardo V, Rugolo M, Ferretti L, Gandini F, Pala M, Achilli A, Olivieri A, Torroni A, Carelli V. A Novel in-Frame 18-bp Microdeletion in MT-CYB Causes a Multisystem Disorder with Prominent Exercise Intolerance. HumMutat. 2014 Aug;35(8):954-8 [IF 2014: 5.144]
  38. La Morgia C, Caporali L, Gandini F, Olivieri A, Toni F, Nassetti S, Brunetto D, Stipa C, Scaduto C, Parmeggiani A, Tonon C, Lodi R, Torroni A, Carelli V. Association of the mtDNA m.4171C>A/MT-ND1 mutation with both optic neuropathy and bilateral brainstem lesions. BMC Neurol. 2014 May 28;14:116. [IF 2014: 2.040]
  39. Barboni P, Savini G, Cascavilla ML, Caporali L, Milesi J, Borrelli E, La Morgia C, Valentino ML, Triolo G, Lembo A, Carta A, De Negri A, Sadun F, Rizzo G, Parisi V, Pierro L, Bianchi Marzoli S, Zeviani M, Sadun AA, Bandello F, Carelli V. Early Macular Retinal Ganglion Cell Loss in Dominant Optic Atrophy: Genotype-Phenotype Correlation. Am J Ophthalmol. 2014 Sep; 158(3):628-636 [IF 2014: 3.871]
  40. La Morgia C, Carbonelli M, Barboni P, Sadun AA, Carelli V. Medical management of hereditary optic neuropathies. Front Neurol. 2014 Jul 31;5:141 [IF 2015:3.184].
  41. Carelli V, Sabatelli M, Carrozzo R, Rizza T, Schimpf S, Wissinger B, Zanna C, Rugolo M, La Morgia C, Caporali L, Carbonelli M, Barboni P, Tonon C, Lodi R, Bertini E. 'Behr syndrome' with OPA1 compound heterozygote mutations. Brain 2015 Jan;138(Pt 1):e321. [IF 2015: 10.103]
  42. Maresca A, Caporali L, Strobbe D, Zanna C, Malavolta D, La Morgia C, Valentino ML, Carelli V. Genetic Basis of Mitochondrial Optic Neuropathies. Curr Mol Med. 2014;14(8):985-992. [IF 2014: 3.621]
  43. Santarelli R, Rossi R, Scimemi P, Cama E, Valentino ML, La Morgia C, Caporali L, Liguori R, Magnavita V, Monteleone A, Biscaro A, Arslan E, Carelli V. OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation. Brain 2015 Mar;138(Pt 3):563-76. [IF 2015: 10.103]
  44. Ziccardi L, Parisi V, Giannini D, Sadun F, De Negri AM, Barboni P, La Morgia C, Sadun AA, Carelli V. Multifocal VEP provide electrophysiological evidence of predominant dysfunction of the optic nerve fibers derived from the central retina in Leber's hereditary optic neuropathy. Graefes Arch Clin Exp Ophthalmol 2015 Mar 17. [Epub ahead of print] [IF 2015: 1.991]
  45. Manners DN, Rizzo G, La Morgia C, Tonon C, Testa C, Barboni P, Malucelli E, Valentino ML, Caporali L, Strobbe D, Carelli V, Lodi R. Diffusion Tensor Imaging Mapping of Brain White Matter Pathology in Mitochondrial Optic Neuropathies. AINR Am J Neuroradiol 2015 2015 Jul;36(7):1259-65 [IF 2015: 3.124]
  46. Baiardi S, La Morgia C, Mondini S, Cirignotta F. A restless abdomen and propriospinal myoclonus like at sleep onset: an unusual overlap syndrome. BMJ Case Rep 2015 Mar 27;2015.
  47. Carelli V, Musumeci O, Caporali L, Zanna C, La Morgia C, Del Dotto V, Porcelli AM, Rugolo M, Valentino ML, Iommarini L, Maresca A, Barboni P, Carbonelli M, Trombetta C, Valente EM, Patergnani S, Giorgi C, Pinton P, Rizzo G, Tonon C, Lodi R, Avoni P, Liguori R, Baruzzi A, Toscano A, Zeviani M. Syndromic parkinsonismand dementia associated with OPA1 missense mutations. Ann Neurol 2015 Jul; 78(1):21-38 [IF 2015: 9.638]
  48. Carbonelli M, La Morgia C, Savini G, Cascavilla ML, Borrelli E, Chicani F, do V F Ramos C, Salomao SR, Parisi V, Sebag J, Bandello F, Sadun AA, Carelli V, Barboni P. Macular Microcysts in Mitochondrial Optic Neuropathies: Prevalence and Retinal Layer Thickness Measurements. PLoS One. 2015 Jun 5;10(6):e0127906. [IF 2015: 3.057]
  49. Abrams AJ, Hufnagel RB, Rebelo A, Zanna C, Patel N , Gonzalez MA, Campeanu IJ, Griffin LB, Groenewald S, Strickland AV , Tao F, Speziani F, Abreu L, Caporali L, La Morgia C, Maresca A, Liguori R. Lodi R, Ahmed ZM, Sund KL, Wang X, Krueger LA , Peng Y, Prada CE, Prows CA, Bove K, Schorry EK, Antonellis A, Zimmerman HH, Abdulrahman OA, Yang Y, Downes SM, Prince J, Fontanesi F, Barrientos A, Nemeth AH, Carelli V, Huang T, Zuchner S, Dallman JE. Recessive mutations in SLC25A46 are associated with an optic atrophy “plus” phenotypic spectrum: characterization of an UGO1-like protein. Nat Genet. 2015 Aug;47(8):926-32. [IF 2015: 31.616]
  50. Giordano L, Deceglie S, d'Adamo P, Valentino ML, La Morgia C, Fracasso F, Roberti M, Cappellari M, Petrosillo G, Ciaravolo S, Parente D, Giordano C, Maresca A, Iommarini L, Del Dotto V, Ghelli AM, Salomao SR, Berezovsky A, Belfort R Jr, Sadun AA, Carelli V, Loguercio Polosa P, Cantatore P. Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways. Cell Death Dis. 2015 Dec 17;6:e2021. [IF 2015: 5.378]
  51. La Morgia C, Ross-Cisneros FN, Koronyo Y, Hannibal J, Gallassi R, Cantalupo G, Sambati L, Pan BX, Tozer KR, Barboni P, Provini F, Avanzini P, Carbonelli M, Pelosi A, Chui H, Liguori R, Baruzzi A, Koronyo-Hamaoui M, Sadun AA, Carelli V. Melanopsin retinal ganglion cell loss in Alzheimer's disease. Ann Neurol. 2016 Jan;79(1):90-109. [IF 2016:9.890]
  52. Balducci N, Savini G, Cascavilla ML, La Morgia C, Triolo G, Giglio R,Carbonelli M, Parisi V, Sadun AA, Bandello F, Carelli V, Barboni P. Macular nerve fibre and ganglion cell layer changes in acute Leber's hereditary optic neuropathy. Br J Ophthalmol. 2016 Sep;100(9):1232-7. [IF 2016:3.806]
  53. Carelli V, d'Adamo P, Valentino ML, La Morgia C, Ross-Cisneros FN, Caporali L, Maresca A, Loguercio Polosa P, Barboni P, De Negri A, Sadun F, Karanjia R, Salomao SR, Berezovsky A, Chicani F, Moraes M, Moraes Filho M, Belfort R Jr, Sadun AA. Parsing the differences in affected with LHON: genetic versus environmental triggers of disease conversion. Brain. 2016 Mar;139(Pt 3):e17. [IF 2016:10.292]
  54. Barboni P, Savini G, Carelli V, Balducci N, La Morgia C, Bandello F, Sadun AA. Re: Pilat et al.: High-resolution imaging of the optic nerve and retina in optic nerve hypoplasia (Ophthalmology 2015;122:1330-9). Ophthalmology. 2016 Mar;123(3):e19-20. [IF 2016: 8.204]
  55. Santarelli R, Cama E, Scimemi P, La Morgia C, Caporali L, Valentino ML, Liguori R, Carelli V. Reply: Both mitochondrial DNA and mitonuclear gene mutations cause hearing loss through cochlear dysfunction. Brain. 2016 Jun;139(Pt6):e34. [IF 2016:10.292]
  56. Yu-Wai-Man P, Votruba M, Burté F, La Morgia C, Barboni P, Carelli V. A neurodegenerative perspective on mitochondrial optic neuropathies. Acta Neuropathol. 2016 Dec;132(6):789-806 [IF 2016:12.213]
  57. Borrelli E, Triolo G, Cascavilla ML, La Morgia C, Rizzo G, Savini G, Balducci N, Nucci P, Giglio R, Darvizeh F, Parisi V, Bandello F, Sadun AA, Carelli V, Barboni P. Changes in Choroidal Thickness follow the RNFL Changes in Leber's Hereditary Optic Neuropathy. Sci Rep. 2016 Nov 17;6:37332. [IF 2016:4.259]
  58. Georg B, Ghelli A, Giordano C, Ross-Cisneros FN, Sadun AA, Carelli V, Hannibal J, La Morgia C. Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always. Mitochondrion. 2017 Apr 12. pii:S1567-7249(17)30087-9. [IF 2016:3.704]
  59. Pisani F, Pavlidis E, Facini C, La Morgia C, Fusco C, Cantalupo G. A 15-year epileptogenic period after perinatal brain injury. Funct Neurol. 2017 Jan/Mar;32(1):49-53. [IF 2016:1.855]
  60. Balducci N, Ciardella A, Gattegna R, Zhou Q, Cascavilla ML, La Morgia C, Savini G, Parisi V, Bandello F, Carelli V, Barboni P. Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy. Mitochondrion. 2017 Mar 10. pii: S1567-7249(17)30061-2. [IF 2016:3.704]
  61. Hwang TJ, Karanjia R, Moraes-Filho MN, Gale J, Tran JS, Chu ER, Salomao SR, Berezovsky A, Belfort R Jr, Moraes MN, Sadun F, DeNegri AM, La Morgia C, Barboni P, Ramos CD, Chicani CF, Quiros PA, Carelli V, Sadun AA. Natural History of Conversion of Leber's Hereditary Optic Neuropathy: A Prospective Case Series. Ophthalmology. 2017 Feb 10. pii: S0161-6420(16)30848-X. [IF 2016: 8.204]
  62. La Morgia C, Ross-Cisneros FN, Sadun AA, Carelli V. Retinal Ganglion Cells and Circadian Rhythms in Alzheimer's Disease, Parkinson's Disease, and Beyond. Front Neurol. 2017 May 4;8:162. [IF 2016: 3.552]
  63. Giannoccaro MP, La Morgia C, Rizzo G, Carelli V. Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease. Mov Disord. 2017 Mar;32(3):346-363. [IF 2016: 7.072]
  64. Caporali L, Maresca A, Capristo M, Del Dotto V, Tagliavini F, Valentino ML, La Morgia C, Carelli V. Incomplete penetrance in mitochondrial optic neuropathies. Mitochondrion. 2017 Jul 14. pii: S1567-7249(17)30207-6. [IF 2016:3.704]
  65. Caporali L, Bello L, Tagliavini F, La Morgia C, Maresca A, Di Vito L, Liguori R, Valentino ML, Cecchin D, Pegoraro E, Carelli V. DGUOK recessive mutations in patients with CPEO, mitochondrial myopathy, parkinsonism and mtDNA deletions. Brain. 2018 Jan 1;141(1):e3. [IF 2016:10.292]
  66. Baiardi S, La Morgia C, Sciamanna L, Gerosa A, Cirignotta F, Mondini S. Is the Epworth Sleepiness Scale a useful tool for screening excessive daytime sleepiness in commercial drivers? Accid Anal Prev. 2018 Jan;110:187-189. [IF 2016:2.685]
  67. Karanjia R, Berezovsky A, Sacai PY, Cavascan NN, Liu HY, Nazarali S, Moraes-Filho MN, Anderson K, Tran JS, Watanabe SE, Moraes MN, Sadun F, DeNegri AM, Barboni P, do Val Ferreira Ramos C, La Morgia C, Carelli V, Belfort R Jr, Coupland SG, Salomao SR, Sadun AA. The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy. Invest Ophthalmol Vis Sci. 2017 May 1;58(6):BIO300-BIO306. [IF 2016: 3.303]
  68. Carelli V, Carbonelli M, de Coo IF, Kawasaki A, Klopstock T, Lagrèze WA, La Morgia C, Newman NJ, Orssaud C, Pott JWR, Sadun AA, van Everdingen J, Vignal-Clermont C, Votruba M, Yu-Wai-Man P, Barboni P. International Consensus Statement on the Clinical and Therapeutic Management of Leber Hereditary Optic Neuropathy. J Neuroophthalmol. 2017 Dec;37(4):371-381. [IF 2016:2]
  69. Carelli V, La Morgia C, Ross-Cisneros FN, Sadun AA. Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet. 2017 Oct 1;26(R2):R139-R150. [IF 2016:5.340]
  70. La Morgia C, Di Vito L, Carelli V, Carbonelli M. Patterns of Retinal Ganglion Cell Damage in Neurodegenerative Disorders: Parvocellular vs Magnocellular Degeneration in Optical Coherence Tomography Studies. Front Neurol. 2017 Dec 22;8:710. [IF 2016: 3.552]
  71. Balducci N, Cascavilla ML, Ciardella A, La Morgia C, Triolo G, Parisi V, Bandello F, Sadun AA, Carelli V, Barboni P. Peripapillary vessel density changes in Leber's hereditary optic neuropathy: a new biomarker. Clin Exp Ophthalmol. 2018 May 22
  72. Caporali L, Iommarini L, La Morgia C, Olivieri A, Achilli A, Maresca A,Valentino ML, Capristo M, Tagliavini F, Del Dotto V, Zanna C, Liguori R, Barboni P, Carbonelli M, Cocetta V, Montopoli M, Martinuzzi A, Cenacchi G, De Michele G, Testa F, Nesti A, Simonelli F, Porcelli AM, Torroni A, Carelli V. Peculiar combinations of individually non-pathogenic missense mitochondrial DNA variants cause low penetrance Leber's hereditary optic neuropathy. PLoS Genet. 2018 Feb14;14(2):e1007210.
  73. Favoni V, Pierangeli G, Toni F, Cirillo L, La Morgia C, Abu-Rumeileh S, Messia M, Agati R, Cortelli P, Cevoli S. Idiopathic Intracranial Hypertension Without Papilledema (IIHWOP) in Chronic Refractory HeadacheFront in Neurol 2018; 9:503. doi: 10.3389/fneur.2018.00503

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