Foto del docente

Alessandra Locatelli

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Publications

Marzano S.; Miglietta G.; Morigi R.; Marinello J.; Arleo A.; Procacci M.; Locatelli A.; Leoni A.; Pagano B.; Randazzo A.; Amato J.; Capranico G., Balancing Affinity, Selectivity, and Cytotoxicity of Hydrazone-Based G-Quadruplex Ligands for Activation of Interferon β Genes in Cancer Cells, «JOURNAL OF MEDICINAL CHEMISTRY», 2022, 65, pp. 12055 - 12067 [Scientific article]Open Access

Francesca Bonvicini, Alessandra Locatelli, Rita Morigi, Alberto Leoni, Giovanna Angela Gentilomi, Isatin Bis-Indole and Bis-Imidazothiazole Hybrids: Synthesis and Antimicrobial Activity, «MOLECULES», 2022, 27, pp. 5781 - 5792 [Scientific article]Open Access

Das A.; Greco G.; Kumar S.; Catanzaro E.; Morigi R.; Locatelli A.; Schols D.; Alici H.; Tahtaci H.; Ravindran F.; Fimognari C.; Karki S.S., Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives, «COMPUTATIONAL BIOLOGY AND CHEMISTRY», 2022, 97, Article number: 107641 , pp. 1 - 18 [Scientific article]Open Access

Morigi R.; Catanzaro E.; Locatelli A.; Calcabrini C.; Pellicioni V.; Leoni A.; Fimognari C., Synthesis and biological evaluation of new bis-indolinone derivatives endowed with cytotoxic activity, «MOLECULES», 2021, 26, Article number: 6277 , pp. 1 - 15 [Scientific article]Open Access

Verardi L.; Fiori J.; Andrisano V.; Locatelli A.; Morigi R.; Naldi M.; Bertucci C.; Strocchi E.; Boga C.; Micheletti G.; Calonghi N., Indole derivative interacts with estrogen receptor beta and inhibits human ovarian cancer cell growth, «MOLECULES», 2020, 25, Article number: 4438 , pp. 1 - 15 [Scientific article]Open Access

Amato J.; Miglietta G.; Morigi R.; Iaccarino N.; Locatelli A.; Leoni A.; Novellino E.; Pagano B.; Capranico G.; Randazzo A., Monohydrazone Based G-Quadruplex Selective Ligands Induce DNA Damage and Genome Instability in Human Cancer Cells, «JOURNAL OF MEDICINAL CHEMISTRY», 2020, 63, pp. 3090 - 3103 [Scientific article]Open Access

Emanuela Pesce, Nicoletta Pedemonte, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Synthesis and biological evaluation of thiazole derivatives on basic defects underlying cystic fibrosis., «BIOORGANIC & MEDICINAL CHEMISTRY LETTERS», 2020, 30, Article number: 127473 , pp. 1 - 7 [Scientific article]Open Access

Alessandra Locatelli, Luisa Iommarini, Alessandra Graziadio, Alberto Leoni, Anna Maria Porcelli, Stefano Iotti, Emil Malucelli, Francesco Francia, Giovanni Venturoli, Giovanna Farruggia, Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose, «RSC ADVANCES», 2019, 9, pp. 15350 - 15356 [Scientific article]Open Access

Morigi, R., Locatelli, A., Leoni, A., Rambaldi, M., Bortolozzi, R., Mattiuzzo, E., Ronca, R., Maccarinelli, F., Hamel, E., Bai, R., Brancale, A., Viola, G., Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2019, 166, pp. 514 - 530 [Scientific article]Open Access

Conti, Ilaria; Morigi, Rita; Locatelli, Alessandra*; Rambaldi, Mirella; Bua, Gloria; Gallinella, Giorgio; Leoni, Alberto, Synthesis of 3-(Imidazo[2,1-b]thiazol-6-yl)-2H-chromen-2-one derivatives and study of their antiviral activity against parvovirus B19, «MOLECULES», 2019, 24, Article number: 1037 , pp. 1 - 15 [Scientific article]Open Access

Leoni, Alberto; Frosini, Maria; Locatelli, Alessandra; Micucci, Matteo; Carotenuto, Claudio; Durante, Miriam; Cosconati, Sandro; Budriesi, Roberta*, 4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2019, 169, pp. 89 - 102 [Scientific article]Open Access

Morigi, Rita; Vitali, Beatrice; Prata, Cecilia; Palomino, Rogers A. A; Graziadio, Alessandra; Locatelli, Alessandra; Rambaldi, Mirella; Leoni, Alberto, Investigation on the effects of antimicrobial imidazo[2,1-b]thiazole derivatives on the genitourinary microflora, «MEDICINAL CHEMISTRY», 2018, 14, pp. 311 - 319 [Scientific article]

R. Morigi, J. Amato, N. Iaccarino, B. Pagano, A. Locatelli, A. Leoni, M. Rambaldi, G. Miglietta, J. Marinello, G. Capranico, E. Novellino, A. Randazzo, Targeting human telomeric and promoter G-quardruplexes: synthesis, biophysical and biological studies of new guanylhydrazones as potential antitumor agents, in: BIONIC 2018: Biology of non-canonical nucleic acids: from humans to pathogens. 26th - 28th September 2018 - Padova, Italy - Abstract Book, Padova, 2018, pp. 126 - 126 (atti di: BIONIC 2018: Biology of non-canonical nucleic acids: from humans to pathogens., Padova, 26-28 settembre 2018) [Abstract]

Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella, A Patent Review on Thiazole Derivatives (2008-2013), «ACTA CHIMICA & PHARMACEUTICA INDICA», 2017, 7, Article number: 103 , pp. 1 - 35 [Scientific article]

Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella, Imidazo[2,1-b] Thiazole: Introduction, Current and Perspective, «BIOENERGETICS», 2017, 6, Article number: Chemistry Journals-17-99R1 , pp. 1 - 3 [Scientific article]