Foto del docente

Alessandra Locatelli

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Publications

N. Iaccarino, J. Amato, R. Morigi, A. Pagano, A. De Magis, G. Capranico, A. Locatelli, A. Graziadio, A. Leoni, M. Rambaldi, E. Novellino, S. Neidle, B. Pagano, A. Randazzo., Toward the development of specific G-quadruplex binders: biophysical studies of new hydrazone derivatives., in: 6th International Meeting on Quadruplex Nuceic Acids: G4thering. Prague, May 31st-June 3rd, 2017 - Abstract Book, 2017, pp. 132 - 132 (atti di: 6th International Meeting on Quadruplex Nuceic Acids: G4thering., Praga, 31 maggio-03 giugno 2017) [Abstract]

Morigi, Rita; Rambaldi, Mirella; Locatelli, Alessandra; Leoni, Alberto, Small-Molecules Targeting Kinases Involved in Pulmonary Hypertension: a Patent Review (2010-2015), «CURRENT MEDICINAL CHEMISTRY», 2016, 23, pp. 3510 - 3527 [Scientific article]

Graziadio, Alessandra; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella, Small-Molecules Targeting Sirtuin 1: A Patent Review (2012-2015), «MEDICINAL CHEMISTRY», 2016, 6, pp. 411 - 421 [Scientific article]

Amato, Jussara; Morigi, Rita; Pagano, Bruno; Pagano, Alessia; Ohnmacht, Stephan; De Magis Alessio; Tiang, Yee-Peng; Capranico, Giovanni; Locatelli, Alessandra; Graziadio, Alessandra; Leoni, Alberto; Rambaldi, Mirella; Novellino, Ettore; Neidle, Stephen; Randazzo, Antonio, Toward the Development of Specific G‑Quadruplex Binders: Synthesis, Biophysical, and Biological Studies of New Hydrazone Derivatives, «JOURNAL OF MEDICINAL CHEMISTRY», 2016, 59, pp. 5706 - 5720 [Scientific article]Open Access

Leoni, Alberto; Locatelli, Alessandra; Morigi, Rita; Rambaldi, Mirella, 2-Indolinone a versatile scaffold for treatment of cancer: A patent review (2008-2014), «EXPERT OPINION ON THERAPEUTIC PATENTS», 2016, 26, pp. 149 - 173 [Scientific article]

Cappadone, C; Stefanelli, C.; Malucelli, E.; Zini, M.; Onofrillo, C.; Locatelli, A.; Rambaldi, M.; Sargenti, A.; Merolle, L.; Farruggia, G.; Graziadio, A.; Montanaro, L.; Iotti, S., P53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells, «BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS», 2015, 467, pp. 348 - 353 [Scientific article]

Morigi Rita; Locatelli Alessandra; Leoni Alberto; Mirella Rambaldi, Recent Patents on Thiazole Derivatives Endowed with Antitumor Activity, «RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY», 2015, 10, pp. 280 - 297 [Scientific article]

Jussara Amato; Nunzia Iaccarino; Bruno Pagano; Rita Morigi; Alessandra Locatelli; Alberto Leoni; Mirella Rambaldi; Pasquale Zizza; Annamaria Biroccio; Ettore Novellino; Antonio Randazzo, Bis-indole derivatives with antitumor activity turn out to be specific ligands of human telomeric G-quadruplex., «FRONTIERS IN CHEMISTRY», 2014, 2, Article number: 54 , pp. 1 - 8 [Scientific article]

Alberto Leoni;Alessandra Locatelli;Rita Morigi;Mirella Rambaldi, Novel thiazole derivatives: a patent review (2008 – 2012; Part 1), «EXPERT OPINION ON THERAPEUTIC PATENTS», 2014, 24, pp. 201 - 216 [Scientific article]

Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi, Novel thiazole derivatives: a patent review (2008-2012. Part.2), «EXPERT OPINION ON THERAPEUTIC PATENTS», 2014, 24, pp. 759 - 777 [Scientific article]

Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Concettina Cappadone; Giovanna Farruggia; Stefano Iotti; Lucia Merolle; Maddalena Zini; Claudio Stefanelli, Substituted E-3-(3-indolylmethylene)1,3-dihydroindol-2-ones with antiproliferative activity. Study of the effects on HL-60 leukemia cells, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2014, 79, pp. 382 - 390 [Scientific article]

Sujeet Kumar; Vidya Gopalakrishnan; Mahesh Hegde; Vivek Rana; Sharad S. Dhepe; Sureshbabu A. Ramareddy; Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Mrinal Srivastava; Sathees C. Raghavan; Subhas S. Karki, Synthesis and antiproliferative activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives, «BIOORGANIC & MEDICINAL CHEMISTRY LETTERS», 2014, 24, pp. 4682 - 4688 [Scientific article]

Aldo Andreani; Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Rinaldo Cervellati; Emanuela Greco; Tamara P. Kondratyuk; Eun-Jung Park; Ke Huang; Richard B. van Breemen; John M. Pezzuto, Chemopreventive and antioxidant activity of 6-substituted imidazo [2,1-b]thiazoles, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2013, 68, pp. 412 - 421 [Scientific article]

A. Andreani; M. Granaiola; A. Locatelli; R. Morigi; M. Rambaldi; L. Varoli; F. Vieceli Dalla Sega; C. Prata; T. L. Nguyen; R. Bai; E. Hamel, Cytotoxic activities of substituted 3-(3,4,5-trimethoxybenzylidene)- 1,3-dihydroindol-2-ones and studies on their mechanisms of action, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2013, 64, pp. 603 - 612 [Scientific article]

Alessandra Locatelli;Sandro Cosconati;Matteo Micucci;Alberto Leoni;Luciana Marinelli;Andrea Bedini;Pierfranco Ioan;Santi Mario Spampinato;Ettore Novellino;Alberto Chiarini;Roberta Budriesi, Ligand Based Approach to L-Type Calcium Channel by Imidazo[2,1-b]thiazole-1,4-Dihydropyridines: from Heart Activity to Brain Affinity, «JOURNAL OF MEDICINAL CHEMISTRY», 2013, 56, pp. 3866 - 3877 [Scientific article]