Foto del docente

Valentina Ambrosini

Associate Professor

Department of Experimental, Diagnostic and Specialty Medicine - DIMES

Academic discipline: MED/36 Imaging and Radiotherapy

Research

Keywords: 68Ga-DOTANOC PET/CT neuroendocrine tumours oncology pulmonary disorders 18F-FDG 18F-DOPA theranostic

Clinical and pre-clinical applications of PET/CT in both humans and small animals, with particular emphasis to oncology and respiratory medicine. Particular interest is devoted to the study of PET/CT employment in highly malignant tumours (e. g. lymphoma, breast, colon, prostate, lung carcinoma, sarcomas, testicular tumours)  for staging, early assessment to therapy response, identification of the primary tumour site in patients with known secondary lesions, early detection of disease relapse after therapy. 

Clinical applications of PET/CT with 18F-FDG and non-FDG tracers (68Ga-DOTANOC, 18F-DOPA 11C-Colina, 11C-Acetato, 11C-Metionina, 68Ga-PSMA). In particolar employment of 68Ga-DOTANOC for the assessment of patients with neuroendocrine tumours. Employment of PET/CT in the study of inflammaotory disorders and lung disorders.

Clinical research:

- imaging of neuroendocrine tumours employing 68Ga-DOTA-NOC PET/CT

- imaging of neuroendocrine tumours employing18F-DOPA PET/CT

- imaging of neuroendocrine tumours employing 18F-FDG PET/CT (low grade forms or low expression of somatostatin receptors)

- 68Ga-DOTA-NOC PET/CT in patients with idiopathic pulmonary fibrosis

- PET/CT imaging of sarcoidosis (disease extension, response to therapy, detection of relapse)

- Role of 11C-Choline PET/CT in prostate tumours

- 18F-FDG PET/CT in staging, restaging, evaluation of response to treatment, follow-up of high grade tumours (e.g. colo-rectal carcinoma, lung cancer, gastric cancer, multiple mieloma, breast cancer, ovarian cancer, GIST, breast cancer, melanoma, Hodgkin and non-Hodgkin lymphoma)

- 18F-FDG PET/CT in the assessment of patients with tubercolosis and fever of unknown origin

- 18F-FDG PET/CT in the clinical management of patients with testicular tumours

- 18F-FDG PET/CT imaging of patients with spondilodyscitis

 

- Clinical applications of novel PET radiopharmaceuticals

Pre-clinical imaging: role of small animal PET in the assessment of murine models of human tumours (Hodgkin and non-Hodgkin lymphoma, lung cancer, neuroblastoma, rhabdomyosarcomas), miocardiac hypoxia, obesity, gynecolagical infection.