Foto del docente

Valentina Ambrosini

Associate Professor

Department of Experimental, Diagnostic and Specialty Medicine - DIMES

Academic discipline: MED/36 Imaging and Radiotherapy

Curriculum vitae

Born in Bologna, Italy, September 29, 1975

Citizenship: Italian

Work Address: Nuclear Medicine, Pad. 30, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italia

Tel. +39 051 2143187; FAX: +39 051 2143956; E-mail: valentina.ambrosini@unibo.it

ACTUAL POSITION

Associate Professor, University of Bologna, Department of Experimental Diagnostic and Specialized Medicine, scientific sector MED/36-Diagnostic Imaging.

Full-time employed Physician in Nuclear Medicine, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi.

Certified Specialist in Nuclear Medicine and Respiratory Medicine

PhD in Respiratory-Cardiac-Thoracic Sciences of medical and surgical interest.

NET Bologna multidisciplinary team, European Neuroendocrine Tumour Society (ENETS) center of Excellence

ACADEMIC CARRER

1994 Diploma di Maturità Scientifica (score 58/60), Liceo Scientifico "E.Fermi", Bologna

1994-2000 Corso di Laurea in Medicina e Chirurgia (M.D), University of Bologna

19/10/2000 Laurea in Medicina e Chirurgia (M.D.), Università di Bologna (score 110/110 cum laude; Thesis title: “Experimental study on the natural history of asthma: from childhood to adulthood”)

2001- I session Abilitazione all’esercizio della Professione di Medico-Chirurgo (Professional Certification), Faculty of Medicine and Surgery, University of Bologna (score 108/110)

2000-2004 Specialty School in Respiratory Medicine, University of Bologna

11/11/2004 Diploma di Specializzazione in Malattie dell’Apparato Respiratorio (Certified Specialist in Respiratory Medicine), University of Bologna, (score 70/70 cum laude; Thesis title: “Role of HRCT in the evaluation of idiopathic interstitial lung disease: analysis of 239 cases”)

March 2003-November 2003 Honorary Research Fellow in Respiratory Medicine, Interstitial Lung Disease Unit, Royal Brompton Hospital, Clinical Genomics Group, National Heart and Lung Institute, Imperial College of ScienceTechnology and Medicine, London, UK

2005-2007 PhD course in Respiratory-Cardiac-Thoracic Sciences of medical and surgical interest, Faculty of Medicine and Surgery, University of Bologna

3/3/2008 PhD diploma in Respiratory-Cardiac-Thoracic Sciences of medical and surgical interest, Faculty of Medicine and Surgery, University of Bologna (Thesis title: “Pre-Clinical Imaging: Small Animal PET and CT applications in Pneumology, Oncology and Cardiology”)

19/03/2008-19/03/2012 Specialty School in Nuclear Medicine, University of Bologna

20/3/2012 Diploma di Specializzazione in Medicina Nucleare (Certified Specialist in Nuclear Medicine) University of Bologna (score 70/70 cum laude; thesis title: “Role of 68Ga-DOTANOC PET/TC in patients with neuroendocrine tumour”)

2011: winner of a full-time university research position (sector MED36-Diagnostic Imaging) (21/3/2011)

2/4/2012-14/9/2014: Full-time Assistant Professor, University of Bologna, Department of Experimental Diagnostic and Specialized Medicine scientific sector MED/36-Diagnostic Imaging

15/9/2014 to present: Associate Professor, University of Bologna, Department of Experimental Diagnostic and Specialized Medicine scientific sector MED/36-Diagnostic Imaging

Member of the Comitato Ordinatore (organizing commitee) of the School of Specialty in Nuclear Medicine (since March 2017)

Director of First Cycle Degree of Imaging and Radiotherapy techniques (elected December 2017- resigned September 2018)

National Academic qualification as Full Professor (Abilitazione Scientifica Nazionale a professore di I fascia 2016-2018 - I quadrimestre): since 2017

SCIENTIFIC ACTIVITY

Author (since 2003; http://www.ncbi.nlm.nih.gov/pubmed ) of 121 scientific articles published on peer-reviewed international or national journals (overall impact factor >412; Scopus (July 2020): H-index= 38, Total Citations= 4329).

Author of >170 abstracts presented at national and international meetings. Invited Speaker at several international and national events.

Author of 18 book chapters. Author and Editor (together with Professor Stefano Fanti) of the book “PET/CT in Neuroendocrine Tumours”, as part of Clinicians’ Guides to Radionuclide Hybrid Imaging. PET/CT Series. Editors: Jamshed B. Bomanji, Gopinath Gnanasegaran, Stefano Fanti, Homer A. Macapinlac. British Nuclear Medical Society. Springer.

Reviewer for the European Journal of Nuclear Medicine and Molecular Imaging, Journal of Nuclear Medicine, Nuclear Medicine Communication, Quarterly journal of nuclear medicine and molecular imaging.

Reviewer for the annual EANM (European Association of Nuclear) conference: 2020,2019,2018,2017, 2016, 2015, 2014, 2013

Reviewer for the ECCO conference: 2016

Member of the Editorial Board of the Journal of Nuclear Medicine 01/01/2017-31/12/2020

Member of the Editorial Board of Cancers since 07/2020

Member of the ESMO (European society of medical oncology) Faculty staff- Neuroeodocrine and Neuroendocrine, Endocrine Neoplasms and CUP, 2017-2025

Center coordinator of the NET Bologna multidisciplinary team, European Neuroendocrine Tumour Society (ENETS) center of Excellence

Member of the advisory board of ENETS (European neuroendocrine tumour society)

ENETS theranostic task force Lead

Member of the EANM Oncology and theranostic committee (since 1/1/2021)

Member of the scientific committee of ITANET (Associazione italiana per i tumori neuroendocrini, Italian association for neuroendocrine tumours): since 2015

Member the ITANET guidelines task force

Member of the “Centro di Studi e di Ricerca (CSR) sui tumori neuroendocrini del Dipartimento di Scienze Mediche e Chirurgiche (“Center for research and study on neuroendocrine tumours”, Department of medical and surgical sciences) of the University of Bologna.

Author of the EANM guidelines for the use of PET/CT in neuroendocrine tumours (version 2010 and 2017.

Author of the AIOM (Italian association of medical oncology) guidelines for neuroendocrine tumours: 2015, 2016, 2017,2019.

Author of the AIMN (Italian Association of Nuclear Medicine) procedural guidelines for imaging with DOTA-peptides: 2017

Reviewer for ESMO-EURACAN Clinical Practice Guidelines 2020 on Adrenocortical carcinomas and malignant pheochromocytomas

Member of the panel of the Regione Emilia-Romagna of “Appropriate use criteria of PET in lung cancer (Dossier n. 219/2012 - Criteria for appropriate use of FDG-PET in lung cancer. Orientamenti 6).

PhD thesis entitled “Pre-Clinical Imaging: Small Animal PET and CT applications in Pneumology, Oncology and Cardiology” is archived at the University of Bologna and legally deposited at the Central National Library of Florence and Rome.

Winner of three academic prizes issued by the Society of Nuclear Medicine, the Federazione italiana per la ricerca sulle radiazioni e Società Italiana per le ricerche sulle radiazioni, and University of Bologna.

One nomination for the Marie Curie award: 2009

Member of the evaluation committee of a PhD thesis issues by the Faculty of Health Sciences, University of Southern Denmark, entitled “FDG-PET/CT in diffuse large B-cell lymphoma Early response evaluation and clinical utility of FDG-PET/CT” (2014)

Member of the VQR 2011-2014 team of the DIMES, University of Bologna

ACADEMIC ACTIVITY

1. Lectures at courses of the University of Bologna: School: Medicine

- Degree programme: First cycle degree programmes (L) in Imaging and Radiotherapy techniques 39386 – Nuclear medicine imaging- 3 cfu- Module of Radiological Imaging V (I.C.)

AA: 2013-2014; 2014-2015, 2015-2016; 2016-2017, 2017-2018, 2018-2019, 2019-2020, 2020-2021

- Degree programme: Single cycle degree programmes (LMCU) in Medicine and Surgery; 20756 - Imaging Diagnostics and Radiotherapy (A-K) (AK-A) - 4 cfu- Module of Diagnostic Imaging and Radiotherapy (C.I.)

AA: 2014-2015, 2015-2016, 2016-2017, 2017-2018, 2018-2019, 2019-2020, 2020-2021

- Degree programme: Single cycle degree programmes (LMCU) in Medicine and Surgery; 71021 - Neuroendocrine Tumors Diagnosis - 1 cfu- Module of Neuroendocrine Tumors of the Gastroenteropancreatic Tract (NET-GEP): Medical-Surgical Diagnosis and Therapy

AA: 2015-2016, 2016-2017, 2017-2018, 2018-2019, 2019-2020, 2020-2021

- Single cycle degree/Combined Bachelor and Master - 300/360 ECTS- 1cfu as part of DIAGNOSTIC TECHNOLOGY (I.C.): Radiology, Nuclear Medicine and Radioprotection (Language: English)

AA 2019-2020, 2020-2012

- Lectures to the residents of several School Medical Specialties (Nuclear Medicine, Radiology, Radiotherapy).

2. Thesis:

- 2007-2012: students tutoring for the design, start up, review and completion of the thesis projects (main supervisor Prof Fanti).

- since 2012: I was main supervisor of eight thesis of the degree programme in Medicine and Surgery and of two specialty thesis in Nuclear medicine.

3. Director of First Cycle Degree of Imaging and Radiotherapy techniques: December 2017-September 2018

Foreign languages

English: Cambridge Certificate of Proficiency in English (1993).

French: Good scholastic Knowledge

PROFESSIONAL CARRER

1999-09/2000 Residency in Paediatrics (Respiratory Medicine)

10/2000-12/2000 Residency in Respiratory Medicine

2000-2004 Specialty in Respiratory Medicine: Resident in training

2003 Fully registered Medical Practitioner General Medical Council (UK)

04/2005-04/2008 Contract at the Nuclear Medicine Unit, Azienda Ospedaliero-Universitaria di Bologna Policlinico S.Orsola-Malpighi, Bologna

03/2008-03/2012 Specialty in Nuclear Medicine: Resident in training

2/4/2012: Full time Research position at the University of Bologna (sector MED/36-Diagnostic Imaging).

15/4/2012-to present: Full time physician in Nuclear Medicine, Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi.

COURSES

-BLSD-B. (2004, 2014, 2018) Azienda Ospedaliero-Universitaria di Bologna, Policlinico S.Orsola-Malpighi).

-Post-graduate course. Molecular mechanisms of lung carcinogenesis: translational applications. American Thoracic Society San Diego, 20-25 May 2005.

-European Pediatric Immediate Life Support (EPILS). Italian Resuscitation Council. 9/12/2013, Policlinico S.Orsola-Malpighi, Bologna

- BLSD (Basic life support defibrillation)-10/12/2014.

FIELDS OF INTEREST

Clinical and pre-clinical applications of PET/CT in both humans and small animals, with particular emphasis to oncology and respiratory medicine. Particular interest is devoted to the study of PET/CT employment in highly malignant tumours (e.g. lymphoma, breast, colon, prostate, lung carcinoma, sarcomas, testicular tumours, gynaecological tumours, myeloma) for staging, early assessment to therapy response, identification of the primary tumour site in patients with known secondary lesions, early detection of disease relapse after therapy.

Clinical applications of PET/CT with 18F-FDG and non-FDG tracers (68Ga-DOTANOC, 18F-DOPA, 11C-Colina, 11C-Metionina, 68Ga-PSMA). In particular employment of 68Ga-DOTANOC for the assessment of patients with neuroendocrine tumours. Employment of PET/CT in the study of inflammatory disorders and lung disorders.

GRANTED PROJECTS

As participant1- ‘Sviluppo dell’imaging molecolare in vivo’ (in vivo experimental molecular imaging). Progetto Pluriennale. Università di Bologna. Anni 2004-2006. Dipartimento Clinico di Scienze Radiologiche e Istopatologiche. Coordinatore: Prof Stefano Fanti (MED36). PhD Student 2- ‘Valutazione del ruolo della PET nel follow-up dei pazienti con linfoma maligno (Evaluation of the role of PET in the follow-up of lymphoma patients). Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2005. Coordinatore: Prof Stefano Fanti (MED36). PhD Student 3- Valutazione del ruolo della 18F-di-idrossi-fenil-alanina (18F-DOPA) nella diagnostica per immagini mediante Tomografia ad Emissione di Positroni (PET) nello studio di neoplasie umane di derivazione neuroendocrina. Progetto Strategico di Ateneo 2005. Coordinatore: Prof Stefano Fanti (MED36). PhD Student 4- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2006. Coordinatore: Prof Stefano Fanti (MED36). Principali linee di ricerca: PET/TC nella stadiazione oncologica, nella valutazione della terapia oncologica, nella valutazione di efficacia di nuovi traccianti PET. PhD Student 5- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2007. Coordinatore: Prof Stefano Fanti (MED36). Principali linee di ricerca: Preclinica nuovi traccianti PET; Preclinica valutazione efficacia nuove terapie; PET/TC valutazione della terapia oncologica; PET/TC stadiazione oncologica; PET/TC clinica nuovi traccianti; PhD Student 6- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2008. Coordinatore: Prof Stefano Fanti (MED36). PhD Student 7- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2009. Coordinatore: Prof Stefano Fanti (MED36). Resident in Nuclear Medicine8- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2010. Coordinatore: Prof Stefano Fanti (MED36). Resident in Nuclear Medicine9-Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2011. Coordinatore: Prof Stefano Fanti (MED36). Resident in Nuclear Medicine As principal coordinator10- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2012. Coordinatore: Valentina Ambrosini (MED36). 11- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2013. Coordinatore: Valentina Ambrosini (MED36). 12- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2014. Coordinatore: Valentina Ambrosini (MED36).13- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2015-2016. Coordinatore: Valentina Ambrosini (MED36). 14- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2017. Coordinatore: Valentina Ambrosini (MED36). 15- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2018. Coordinatore: Valentina Ambrosini (MED36).16- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2019. Coordinatore: Valentina Ambrosini (MED36).17- Progetti di ricerca fondamentale orientata. Università di Bologna RFO (ex60%). Anno 2020. Coordinatore: Valentina Ambrosini (MED36).