Foto del docente

Silvia Gobbi

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Publications

A. Bisi;S. Gobbi;F. Belluti;A. Rampa, Design of Multifunctional Compounds for Cardiovascular Disease: From Natural Scaffolds to “Classical” Multitarget Approach, «CURRENT MEDICINAL CHEMISTRY», 2013, 20, pp. 1759 - 1782 [Scientific article]

Federica Belluti;Remo Perozzo;Leonardo Lauciello;Francesco Colizzi;Dirk Kostrewa;Alessandra Bisi;Silvia Gobbi;Angela Rampa;Maria Laura Bolognesi;Maurizio Recanatini;Reto Brun;Leonardo Scapozza;Andrea Cavalli, Design, Synthesis, and Biological and Crystallographic Evaluation of Novel Inhibitors ofPlasmodium falciparumEnoyl-ACP-reductase (PfFabI), «JOURNAL OF MEDICINAL CHEMISTRY», 2013, 56, pp. 7516 - 7526 [Scientific article]

Rampa A;Gobbi S;Belluti F;Bisi A, Emerging targets in neurodegeneration: new opportunities for Alzheimer's disease treatment?, «CURRENT TOPICS IN MEDICINAL CHEMISTRY», 2013, 13, pp. 1879 - 1904 [Scientific article]

Silvia Gobbi;Qingzhong Hu;Matthias Negri;Christina Zimmer;Federica Belluti;Angela Rampa;Rolf W. Hartmann;Alessandra Bisi, Modulation of Cytochromes P450 with Xanthone-Based Molecules: From Aromatase to Aldosterone Synthase and Steroid 11β-Hydroxylase Inhibition, «JOURNAL OF MEDICINAL CHEMISTRY», 2013, 56, pp. 1723 - 1729 [Scientific article]

Federica Belluti;Angela Rampa;Silvia Gobbi;Alessandra Bisi, Small-molecule inhibitors/modulators of amyloid-β peptide aggregation and toxicity for the treatment of Alzheimer's disease: a patent review (2010 – 2012), «EXPERT OPINION ON THERAPEUTIC PATENTS», 2013, 23, pp. 581 - 596 [Scientific article]

A. Rampa; M. Bartolini; A. Bisi; F. Belluti; S. Gobbi; V. Andrisano; A. Ligresti; V. Di Marzo, The first dual ChE/FAAH inhibitors: new perspectives for Alzheimer's disease?, «ACS MEDICINAL CHEMISTRY LETTERS», 2012, 3, pp. 182 - 186 [Scientific article]

S. Rizzo; A. Tarozzi; M. Bartolini; G. Da Costa; A. Bisi; S. Gobbi; F. Belluti; A. Ligresti; M. Allarà; J-P. Monti; V. Andrisano; V. Di Marzo; P. Hrelia; A. Rampa, 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2012, 58, pp. 519 - 532 [Scientific article]

A. Rampa; F. Belluti; S. Gobbi; A. Bisi, Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease, «CURRENT TOPICS IN MEDICINAL CHEMISTRY», 2011, 11, pp. 2716 - 2730 [Scientific article]

S. Rizzo; A. Bisi; M. Bartolini; F. Mancini; F. Belluti; S. Gobbi; V. Andrisano; A. Rampa, Multi-target strategy to address Alzheimer’s disease: Design, synthesis and biological evaluation of new tacrine-based dimers, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2011, 46, pp. 4336 - 4343 [Scientific article]

Gobbi S.; Zimmer C.; Belluti F.; Rampa A.; Hartmann R.W.; Recanatini M.; Bisi A., Novel highly potent and selective nonsteroidal aromatase inhibitors: synthesis, biological evaluation and structure-activity relationships investigation, «JOURNAL OF MEDICINAL CHEMISTRY», 2010, 53, pp. 5347 - 5351 [Scientific article]

S. Rizzo; M. Bartolini; L. Ceccarini; L. Piazzi ; S. Gobbi; A. Cavalli; M. Recanatini; V. Andrisano; A. Rampa, Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238, «BIOORGANIC & MEDICINAL CHEMISTRY», 2010, 18, pp. 1749 - 1760 [Scientific article]

S. Bova; S. Saponara; A. Rampa; S. Gobbi; L. Cima; F. Fusi; G. Sgaragli; M. Cavalli; C. de los Rios; J. Striessnig; A. Bisi, Anthracene Based Compounds as New L-type Ca2+ Channel Blockers: Design, Synthesis, and Full Biological Profile, «JOURNAL OF MEDICINAL CHEMISTRY», 2009, 52, pp. 1259 - 1262 [Scientific article]

Lim H.D.; Istyastono E.P.; van de Stolpe A.; Romeo G.; Gobbi S.; Schepers M.; Lahaye R.; Menge W.M.; Zuiderveld O.P.; Jongejan A.; Smits R.A.; Bakker R.A.; Haaksma E.E.; Leurs R.; de Esch I.J., Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies., «BIOORGANIC & MEDICINAL CHEMISTRY», 2009, 17, pp. 3987 - 3994 [Scientific article]

F. Belluti; L. Piazzi; A. Bisi; S. Gobbi; M. Bartolini; A. Cavalli; P. Valenti; A. Rampa, Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, «EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY», 2009, 44, pp. 1341 - 1348 [Scientific article]

Barbera M.; Kettunen M. I.; Caputo A.; Hu D. E.; Gobbi S.; Brindle K. M.; Carrara M., Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: a comparative study to DMXAA., «INTERNATIONAL JOURNAL OF ONCOLOGY», 2009, 34, pp. 273 - 279 [Scientific article]