Foto del docente

Silvia Cetrullo

Senior assistant professor (fixed-term)

Department of Biomedical and Neuromotor Sciences

Academic discipline: BIO/10 Biochemistry

Research

Biochemical aspects of signal transduction, autophagy, growth, differentiation, endoplasmic reticulum stress, apoptosis and senescence of human and mammalian cells, also in relation to pathological conditions, such as arthritic and cardiovascular diseases. Epigenetic changes in degenerative pathologies, role of microRNAs. Polyamine metabolism in different cellular models and their involvement in proliferation, autophagy and apoptosis. Nutritional elements and bioactive components in foods: their role in the prevention of cardiovascular and osteoarthritic disease.

 

Main experimental models:

1) primary cultures of chondrocytes and chondrocyte-derived cell lines, treated with various stimuli, such as pro-inflammatory and anti-inflammatory cytokines and oxidative stress;

2) primary cultures of cardiomyocytes and cardiac cell lines (H9c2), submitted to stress conditions and neuro-hormonal factors;

3) mesenchymal stem cells from various sources stimulated to differentiation towards different phenotypes for regenerative medicine.

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