Foto del docente

Roberto Mandrioli

Associate Professor

Department for Life Quality Studies

Academic discipline: CHIM/08 Pharmaceutical Chemistry

Curriculum vitae

Roberto Mandrioli

Born in Rimini (Italy), May 30, 1970

Resident in Rimini, Viale G. Puccini 6/C (Cell. +39 340 3760824)


1989 Secondary schools: school leaving examination (taken after five years of 'Liceo' specializing in scientific studies) passed with full marks (60/60 points).

1995 Graduation in Pharmaceutical Chemistry and Technology at the University of Bologna, with full marks (110/110 cum laude). Experimental thesis work on Chemical-Pharmaceutical Analysis II, entitled "Analysis for toxicological purposes of heavy metal traces in technological substances".

1998 Specialisation in Toxicology at the University of Bologna, with full marks (70/70 cum laude). Experimental thesis work entitled "Development of new analytical methods for the monitoring of novel psychotropic drugs within the frame of pharmaco-toxicological studies".


1994-1995 At the Pharmaco-Toxicological Analysis Laboratory (Department of Pharmaceutical Sciences, Faculty of Pharmacy), University of Bologna, directed by Prof. Maria Augusta Raggi for the preparation of his experimental thesis work on the determination of heavy metals in complex matrices. Works on the analysis of active principles in pharmaceutical formulations as well.

1995-1998 While attending the Specialisation School, collaborates (as part of the internship) with the Pharmaco-Toxicological Analysis Laboratory for the development and implementation of instrumental analytical methods for the determination of active principles and natural compounds in formulations and biological fluids.

1999-2001 Wins a two-year grant ("assegno di ricerca") of the University of Bologna to participate in a research on "Development of new analytical methods for the therapeutic monitoring of novel antipsychotic and antidepressant drugs", under the supervision of Prof. M.A. Raggi.

2001- 2004 The research grant is renewed two times and the research field is broadened to include antiepileptic drugs.

March 2005 Dr. Mandrioli obtains a full-time position as a Researcher at Bologna University, Faculty of Pharmacy.

March 2008 Confirmation of the permanent Researcher position.

2011-present Member of the Interdepartmental Centre for Industrial Research – Advanced Applications in Mechanical Engineering and Materials Technology, Bologna University, within the Operating Unit 6 – Innovative Technologies for Fashion (Rimini branch).

2012-present Founding and present-day member of the Department for Life Quality Studies, Bologna University, Rimini Campus

September 2014 Dr. Mandrioli obtains a full-time position as an Associate Professor at Bologna University, Department for Life Quality Studies.


Roberto Mandrioli has carried out a constant and consistent scientific research activity in the field of pharmaceutical and toxicological analysis starting from his graduation, and this activity is highlighted by the number and continuity of his scientific papers (94 in 22 years) published in international impacted journals, and symposium communications (159 in 22 years), as well as by his associate professor permanent position and his participation in research projects funded by Universities and Ministries (RFO, PRIN, FIRB, Long-Term Research Plans).

Bibliographic statistics:

N. of publications: 106 (4.4/year)

Total Impact Factor: 282 (average IF = 2.66; IF/year = 11.7)

N. of citations: 2628 (24.8/paper), Scopus

H-index: 32, Scopus

First author: 29 papers

Second author: 37 papers

Last author: 2 papers

His scientific research activity spans the following five main fields:

1. Development of analytical methods for the separation and determination of central nervous system drug compounds (e.g. antipsychotic, antidepressant and antiepileptic drugs) for therapeutic drug monitoring purposes.

2. Analysis of hormones, neuro-hormones, abuse drugs and metabolites in biological fluids.

3. Extraction and analysis of active principles from plant materials.

4. Quality control of pharmaceutical formulations.

5. Development of other methods for pharmaceutical-toxicological purposes.


Dr. Mandrioli has fruitful collaborations with the following Research Agencies:

Department of Pharmacology, University of Bologna

Institute of General Histology and Embryology, University of BolognaInstitute of Psychiatry, University of BolognaInstitute of Chemical Methodologies, National Council of Research, Rome

Institute for Analytical Chemistry, University of Vienna

Department of Life Sciences, University of Modena and Reggio Emilia

Department of Medicinal Chemistry and Technology, University of Perugia

Department for Antidrug Policies, Presidency of the Council of Ministers, Rome.

  • Principal Investigator– Fundamental Oriented Research funds (RFO). Research projects in the field of pharmaceutical-toxicological analysis (2012-today).
  • Member – Fundamental Oriented Research funds (RFO). Research projects in the field of pharmaceutical-toxicological analysis (1998-2011).
  • Co-Applicant - World Antidoping Agency (WADA, 2018), project “Enhanced urinary stability and detection window of peptide hormones and growth factors by dried urine microsampling” (2017 WADA Research Grants Section A: Ref. 17A20LM).
  • Member – European Erasmus+ project (2015-2018) - “TOX-OER - Learning Toxicology through Open Educational Resources” (Ref. 2015-1-ES01-KA203-015957)
  • Member – Cassa di Risparmio of Imola Foundation, project "New approaches for psychiatric patient care: TDM (therapeutic drug monitoring) for therapy optimization and toxic effect reduction" (2011).
  • Member – Presidency of the Council of Ministers, Department for Antidrug Policies, three studies: "VulCan – Evaluation of the vulnerability to Cannabisuse and addiction: neuro-endocrine correlations and quali-quantitative aspects" (2010-2014); "Metabolic disruptions correlated to behavioural anomalies and to psychotropic substance consumption"(2006-2008); "Metabolic and neuroendocrine disruptions correlated to psychotropic substance consumption" (2005-2006).
  • Member – Scientific Research Projects of High National Importance (PRIN) funds, project "Development of integrated analytical methods for the identification and characterisation of multi-target ligands for the prevention and the treatment of neuro-degenerative diseases" (2009-2010).
  • Member – Scientific Research Projects of Relevant National Importance (PRIN) funds, project "Advanced analytical methods for the development and the safe and effective use of drugs" (2007-2008).
  • Member – Scientific Research Projects of Relevant National Importance (PRIN) funds, project "Advanced analytical methods for the safe and effective use of drugs" (2002-2003).
  • Member – Institutional Funds for Basic Research (FIRB), project "New antipsychotic drugs: pharmacokinetic, pharmacodynamic and monitoring studies for therapy optimisation" (2001-2003).
  • Member –Long-Term University Research Plans funds, project "New technologiesfor the targeting and release controlof peptidic drugs with critical biopharmaceutical characteristics: antimicrobials, hypoglycaemics" (2005-2006).
  • Member – Long-Term University Research Plansfunds, project "Development and functional evaluation of new formulations for the release control and targeting of drugs related to anticancer therapy" (2001-2002).


- Teaching

AY 2016/17-today "Drug Analysis I" course (8 ECTS Credits, 14 ECTS Credits until 2017/18, Pharmacy, Rimini)

AY 2004/05, 2005/06, "Quantitative Analysis" module (7 ECTS Credits) of the "Drug Analysis I" 2014/15, 2015/16 course (Pharmacy, Rimini)

AY 2006/07 - 2008/09 "Chemical-Toxicological Analysis I" course (7ECTS Credits, Environmental Toxicology, Bologna)

AY 2008/09 - 2010/11 "Quantitative Analysis" module (5 ECTS Credits) of the “Pharmaceutical Analysis I” course (Quality Control of Health Products, Rimini)

AY 2009/10 – 2011/12 "Special Methodologies in Pharmaceutical Analysis" course (7 ECTS Credits, Pharmacy, Rimini)

AY 2012/13-2017/18 "Health Products' Analysis I" course, both modules: "Qualitative Analysis" and "Quantitative Analysis" (10 ECTS Credits, Quality Control of Health Products, Rimini)

AY 2012/13-present Member of the Promoting Committee of the II Level Master in "Forensic Chemical and Chemical-Toxicological Analysis", Bologna University. He also teaches the "Pharmaceutical Analysis for Forensic Purposes" course (4 ECTS Credits)within this Master.

AY 2013/14-2015/16 Member of the Board of Teachers, Research Doctorate in "Pharmacological and toxicological, human developmental and movement sciences", University of Bologna, Rimini Campus.

- Board of examiners memberships

2001-2013 "Chemical-Toxicological Analysis" course (CTF, Bologna)

2003-2013 "Drug Analysis II" and "Purification of Active Principles" courses (CTF, Bologna)

2005-present "Drug Analysis I", "Drug Analysis II", "Molecular Basis of Drug Activity", "Medicinal and Toxicological Chemistry II", "Special Methodologies in Pharmaceutical Analysis" courses (Pharmacy, Rimini).


- Board memberships

2005-2008 and

2012-2014 "Hours and schoolroom schedule" board.

2007-2009 and

2014-present "Student Dossier Inquiry" board for the graduation course in Pharmacy (Rimini).

2009-2014 "Student Dossier Inquiry" board for the graduation course in Quality control of Health Products (Rimini).

2009-2012 "Joint Committee for the Quality of Didactics"board (until termination).

2005-2017 "Guidance and external relationships" service.

2010 Member of two Committees for Comparative Evaluations for a temporary position, "technical, technical-scientific and data elaboration" area, Rimini


1999 Winner (with co-authors) of the "10 years of Prozac" prize awarded by Eli Lilly Italy, with a scientific study entitled: "Interdisciplinary Research Results on the Psychiatric Use of Fluoxetine, a Potent SSRI Drug".


Since 2017: member of the Editorial Board of the international open-access journal "Journal of Clinical Intensive Care and Medicine".

Member of the Organising Committee of the International Meeting TDM 2008 "Therapeutic and Toxic Effects of Central Nervous System Drugs: The Importance of Drug Monitoring", Bologna, October 2-3, 2008.

Member of the Scientific Committees of:

- RDPA 2011 - 14th International Meeting "Recent Developments in Pharmaceutical Analysis", Pavia, September 21-24, 2011;

- RDPA 2015 - "Recent Developments in Pharmaceutical Analysis", Perugia, June 28 – July 1, 2015.

- RDPA 2017 - "Recent Developments in Pharmaceutical Analysis", Rimini, September 20-22, 2017.

Member of the Organising Committee of NPCF6 - 6° Meeting on "new Perspectives in Medicinal Chemistry", Riccione, April 15-17, 2012.

2010-2017: member of the Board, Intradivisional Group of Drug Analysis within the Medicinal Chemistry Division, Italian Chemical Society.

He has been member of the ACS (American Chemical Society); currently is member of SCI (Italian Chemical Society) and SITOX (Italian Toxicology Society.

He acts as a reviewer for the following 37 international scientific journals: American Journal of Plant Sciences, Analytica Chimica Acta, Analytical Letters, Arabian Journal of Chemistry, Chemical Industry & Chemical Engineering Quarterly, Chromatographia, Clinica Chimica Acta, Clinical Drug Investigation, ClinicoEconomics and Outcomes Research, Desalination and Water Treatment, Drug & Chemical Toxicology, Drug Design, Development and Therapy, Drug, Healthcare and Patient Safety, Electrophoresis, European Endocrinology, European Food Research and Technology, Expert Opinion on Drug Metabolism and Toxicology, Expert Opinion on Pharmacotherapy, Food Additives and Contaminants, International Journal of Analytical Chemistry, International Journal of Nanomedicine, Journal of Affective Disorders, Journal of Chromatographic Science, Journal of Chromatography B, Journal of Clinical Intensive Care and Medicine, Journal of Clinical Psychopharmacology, Journal of Horticulture Science and Forestry, Journal of Microencapsulation, Journal of Pharmaceutical and Biomedical Analysis, Journal of Pharmacy and Pharmacology, Natural Product Research, Neuropsychiatric Disease and Treatment, Patient Preference and Adherence, Plant Biosystems, Psychiatry & Clinical Neurosciences, South African Journal of Botany e Therapeutic Advances in Psychopharmacology.