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Maurizio Brigotti

Associate Professor

Department of Experimental, Diagnostic and Specialty Medicine - DIMES

Academic discipline: MED/04 Experimental Medicine and Pathophysiology

Research

Keywords: neutrophils Toll-like receptor 4 DNA damage and repair Shiga toxin-producing Escherichia coli Shiga toxins hemolytic uremic syndrome

Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in early childhood, and is also characterised by  hemolytic anemia and thrombocytopenia. Most HUS cases occur as a consequence of intestinal infections with Shiga toxin(Stx)-producing Escherichia coli strains. Renal endothelial injury induced by Stx is the primary pathogenetic event in HUS.

  1. Diagnosis and pathogenesis of HUS: set up of new methods for detecting Stx in the blood stream of HUS patients; study of the kinetics of Stx in patients during the natural course of HUS; study of the role of neutrophils in the delivery of Stx from the gut to the kidney and study of the relationship between the amounts of Stx in blood and the clinical features of HUS patients.
  2. Molecular mechanism of action of Stx in endothelial cells: study of the DNA damage and of the target genes, study of the effect of Stx on the repair of DNA, study of the up-regulating effect of Stx on pro-inflammatory genes.

 

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