Foto del docente

Matilde Yung Follo

Associate Professor

Department of Biomedical and Neuromotor Sciences

Academic discipline: BIO/16 Human Anatomy


Keywords: Signal Transduction Human Anatomy Myelodysplastic Syndromes

Involvement of nuclear lipid signalling pathways in patients affected by Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML):

1. Analysis of phosphoinositide-phospholipase C (PI-PLC) beta1: fluorescence in situ hybridization (FISH) analysis aimed at identifying a mono-allelic deletion of the PI-PLCbeta1 gene in patients affected by MDS or AML, and quantification of the gene and protein expression of PI-PLCbeta1 splicing variants in basal conditions and during therapeutic protocols;

2. Analysis of the epigenetic involvement of PI-PLCbeta1 promoter gene in MDS/AML: effect of demethylating treatments on patients affected by MDS;

3. Analysis of PI3K, Akt, Erk and their downstream targets in MDS and AML patients: activation and the role of these pathways in high-risk MDS and AML.

The Impact Factor of papers on peer reviewed journals, according to the ISI-JCR2017 is 250.822 (average: 5.97); the total cites (Scopus Database) is 1565. h-index=25 (Scopus Database).


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