Research activities mainly focused on head and neck, breast and
central nervous system pathology.
Breast: Androgen receptor expression in female breast cancer.
Squamous cells carcinoma of the head and neck: impact of methylation profiles in oral squamous cell carcinoma.
Field cancerization in the tumours of the sino-nasal region.
CNS: CoViD-19 lesions of the brain.
Research activities are mainly focused on endocrine and exocrine
glands, head and neck and central nervous system tumours.
Breast carcinomas are under evaluation using
macrosections. These macrosections (large histological sections)
are proved to be useful to determine the real extent and
intra-mammary growth of in situ and invasive caricnoma. Special
attention is now focused on pleomorphic invasive lobular
carcinoma.
Squamous cell carcinoma of the oral (OSC)
cavity, even if presenting at early stage (pT1\pT2) can
frequently recur and metastatize. Furthermore the oral cavity
can be affected by tumours originating from the salivary glands.
The treatment of these latter tumour is mainly based on surgical
resection as they do not respond to radio and or chemotherapy
The study aims at retrospectively and prospectively identifying
markers transcripts to be utilized for the prediction aggressive
behaviour in patients presenting OSC at early stage and in cases of
salivary gland carcinomas.
In addition the impact of specific miRNA in the neoplastic
tranformation and progression is under evaluation.
The genetic profile of salivary gland tumours
with epithelial and myoepithelial differentiation is under
evaluation.
Finally a retrospective series of osteosarcomas of the
jaws is under evaluation.
CNS: brain tissue changes in CoV-2 patients.
