Molecular bases of cleft lip and palate The goal of the project is
the identification of genes involved in nonsyndromic cleft lip and
palate (CL/P).
In the last years we have been collecting a large sample of CL/P
patients that allows us to evaluate the involvement of candidate
genes and chromosome regions of interest by parametric and
non-parametric genetic approaches. Several contributes have been
already published, however, additional efforts are needed to
understand genetic bases of CL/P. Additional studies, regarding
other craniofacial malformation (Apert, Cruzon, and Nager
syndromes), have been performed by our group to elucidate
genotype-phenotype relationships and pathogenic mechanisms.
