Foto del docente

Laura Menotti

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/19 Microbiology


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Publications prior to 2004

Papers before 2004 (in total 18):

Bertucci C., Cimitan S., and Menotti L. Optical biosensor analysis in studying herpes simplex virus glycoprotein D binding to target nectin1 receptor. (2003). J Pharm Biomed Anal 32 (4-5):697-706.

Menotti L., Cocchi F., and Campadelli-Fiume G. Critical residues in the CC' ridge of the human nectin1 receptor V domain enable herpes simplex virus entry into cell and act synergistically with the downstream region. (2002) Virology, 301 (1): 6-12.

Fabre S., Reymond N., Cocchi F., Menotti L., Dubreuil P., Campadelli-Fiume G, and Lopez M. Prominent role of the Ig-like V domain in nectins' trans-interactions: nectin3 and nectin4 bind to the C-C'-C" b -strands of the nectin1 V domain. (2002) J Biol Chem, 277 (30): 27006-27013.

Menotti L., Casadio R., Bertucci C., Lopez M., and Campadelli-Fiume G. Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from herpes simplex virus gD binding site confers high affinity binding to gD. (2002). J Virol 76 (11): 5463-5471.

Cocchi F., Lopez M., Dubreuil P., Campadelli-Fiume G., and Menotti L. Chimeric nectin1-poliovirus receptor molecules identify a nectin1 region functional in herpes simplex virus entry. (2001) J Virol 75 (17):7987-7994.

Menotti L., Avitabile E., Dubreuil P., Lopez M., and Campadelli-Fiume G. Comparison of murine and human nectin1 binding to herpes simplex virus glycoprotein D (gD) reveals a weak interaction of murine nectin1 to gD and a gD-dependent pathway of entry. (2001) Virology 282 (2): 256-266.

Campadelli-Fiume G., Cocchi F., Menotti L., and Lopez M. The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells. (2000) Rev Med Virol, 10 (5): 305-319. Review.

Menotti L., Lopez M., Avitabile E., Stefan A., Cocchi F., Adelaide J., Lecocq E., Dubreuil P., and Campadelli-Fiume G. The murine homolog of human Nectin1d serves as a species nonspecific mediator for entry of human and animal aherpesviruses in a pathway which is independent of a detectable binding to gD. (2000) Proc Natl Acad Sci USA, 97 (9): 4867-4872.

Cocchi F., Menotti L., Dubreuil P., Lopez M., and Campadelli-Fiume G. Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB). (2000) J Virol 74 (8): 3909-3917.

Lopez M., Cocchi F., Menotti L., Avitabile E., Dubreuil P., and Campadelli-Fiume G. Nectin2a (PRR2a or HveB) and nectin2d are low-efficiency mediators for entry of herpes simplex virus mutants carrying the Leu25Pro substitution in glycoprotein D. (2000) J Virol 74 (3): 1267-1274.

Stefan A., Menotti L., and Campadelli-Fiume G. The biology and natural history of two emerging pathogens: human herpesviruses 6 and 7. (1999) Herpes, the Journal of the IHMF 6 (3): 78-81. Review.

Campadelli-Fiume G., Mirandola P., and Menotti L. Human herpesvirus 6: an emerging pathogen. (1999) Emerg Infect Dis 5 (3): 353-366. Review.

Menotti L., Mirandola P., Locati M., and Campadelli-Fiume G. Trafficking to the plasma membrane of the seven-transmembrane protein encoded by human herpesvirus 6 U51 gene involves a cell-specific function present in T lymphocytes. (1999) J Virol 73 (1): 325-333.

Cocchi F., Lopez M., Menotti L., Aoubala M., Dubreuil P., and Campadelli-Fiume G. The V domain of herpesvirus Ig-like receptor (HIgR) contains a major functional region in herpes simplex virus-1 entry into cells and interacts physically with the viral glycoprotein D. (1998) Proc Natl Acad Sci USA, 95 (26): 15700-15705.

Cocchi F., Menotti L., Mirandola P., Lopez M., and Campadelli-Fiume G. The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells. (1998) J Virol, 72 (12): 9992-10002.

Kempf W., Adams V., Mirandola P., Menotti L., Di Luca D., Wey N., Müller B., and Campadelli-Fiume G. Persistence of human herpesvirus 7 in normal tissues detected by expression of a structural antigen. (1998) J Infect Dis 178 (3): 841-845.

Chang Y.E., Menotti L., Filatov F., Campadelli-Fiume G., and Roizman B. UL27.5 is a novel g2 gene antisense to the herpes simplex virus 1 gene encoding glycoprotein B. (1998) J Virol, 72 (7): 6056-6064.

Kablar B., Vignali R., Menotti L., Pannese M., Andreazzoli M., Polo C., Giribaldi M.G., Boncinelli E., and Barsacchi G. Xotx genes in the developing brain of Xenopus laevis. (1996) Mech Dev, 55 (2): 145-158.


Campadelli-Fiume G, Cocchi F, Menotti L, and Lopez M. HIgR and related V domain for the manufacture of a medicament for preventing or treating HSV-1, HSV-2 and BHV infections. European Patent Office Application nº 98830677.5-5-2105. Depositato il 10-11-1998 in Germania per Brevetto "Europeo" in Europa, USA (brevetto accordato), Giappone. Assegnatari: Università di Bologna (Italia), INSERM (Francia).


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