I work in the field of signal transduction, studying inositide-dependent signaling pathways in different cell types, following these main topics:
- 1-Study of phospholipase C (PLC)-β1- and PLC-g1-dependent signal transduction network in myogenic differentiation. We focus on the identification of new effectors located both in the nuclear and/or in the cytosolic compartment, involved in determining the induction of myogenic differentiation markers.
- 2-Investigation of the effects of therapeutic drugs used in Myelodysplastic Syndromes and Acute Myeloid Leukemia treatment, on inositide-dependent transduction pathways. In particular, we study the role played by phospholipases C (PLC)and the relevance of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR (mammalian Target of Rapamycin) signaling pathway in high-risk MDS patients, in order to identify new predictor factors for the clinical response to pharmacological treatments.
