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Fabiana Morroni

Associate Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIO/14 Pharmacology


Keywords: Alzheimer's disease Bioactive compounds Neuroprotection Parkinson's disease Neurodegeneration

Development of in vitro models of Parkinson's and Alzheimer's diseases

Elucidation of the mechanicistic basis of neuroprotective potential of natural compounds

Development of in vivo models of neurodegeneration


Development of in vitro models of Parkinson's and Alzheimer's diseases in order to study neurodegenerative events induced by specific neurotoxins (6-OHDA and β-amiloid peptide) in neuronal (SH-SY5Y) and glial (C6) cells. Identification of cellular and molecular targets involved in neuronal death.

Evaluation of neuroprotective activity of new compounds using in vitro models of Parkinson's and Alzheimer's diseases, in terms of capability to prevent and rescue the progression of apoptotic and necrotic neuronal death, induced by neurotoxins.

Elucidation of neurodegenerative events in in vivo models of Parkinson's and Alzheimer's diseases. Evaluation of the capability of new agents to counteract crucial biological events involved in neuronal death in specific areas, such as hippocampus and substantia nigra.


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