Rare neurological diseases in children and adolescents
Scientific Coordinator - Prof. Duccio Maria Cordelli
Phenotyping of rare neurological diseases and malformative syndromes with CNS involvement through their electroencephalographic, polysomnographic, neurophysiological and neuroradiological characterization. In last years particular interest has been directed to Mowat-Wilson syndrome and Pallister-Killian syndrome.
Definition of electroclinical phenotype and mechanisms of epileptogenesis in syndromes and neurogenic diseases with epilepsy
Study of disease mechanisms in neurogenetic diseases of childhood
Identification of the genetic basis of rare neurological diseases orphan of diagnosis through new generation technologies
Study of mitochondrial encephalomyopathies in childhood
Evaluation of targeted pharmacological or non-pharmacological therapeutic approaches
Pediatric acute encephalopathies
Scientific Coordinator - Prof. Duccio Maria Cordelli
Phenotyping of neurotoxic and other acute pediatric encephalopathies through their clinical, electroencephalographic/polygraphic, neurophysiological and neuroradiological characterization. In the last years particular interest has been addressed to posterior reversible encephalopathy (PRES).
Study of risk factors, disease mechanisms and prognostic indices in neurotoxic encephalopathies (toxicities from chemotherapy, biologic drugs and post-transplantation)
Study of acute and persistent disturbances of consciousness and responsiveness in urgency/emergency. Role of neurophysiological monitoring methods in intensive care and emergency setting.
Evaluation of epileptic phenomena, such as non-convulsive status epilepticus, as a cause and/or complication of acute encephalopathies. Evaluation of innovative diagnostic strategies and targeted therapeutic approaches.
