EDUCATION
1996- Degree in Chemistry and Pharmaceutical Technologies, University of Bologna, Italy
2002- PhD in Cellular and Molecular Biotechnology, Department of Biochemistry “G.Moruzzi”, University of Bologna, Italy
ACADEMIC ACTIVITY
2000—2011: Permanent Position as Research Associate at the Laboratory of Biochemistry, Department of Biochemistry G.Moruzzi, Faculty of Pharmacy, University of Bologna.
2011-to date: Permanent Position as Research Associate at the Laboratory of Biochemistry, Department of Pharmacy and Biotechnology, University of Bologna.
TEACHING ACTIVITY
2004-2012: BIOCHEMISTRY and APPLIED BIOCHEMISTRY for the Degree in Pharmaceutical Chemistry and Technology, Pharmacy and Applied Pharmaceutical Sciences, University of Bologna
2007-to date:"LABORATORY OF BIOCHEMISTRY", for the Degree in Biotechnology, Department of Pharmacy and Biotechnologyof Bologna.
2016 to date:"ANALYTICAL METODOLOGY AND CLINICAL DIAGNOSTICS" for the School of Specialization in Hospital Pharmacy.
She is supervisor of 20 degree theses for the Degree in Pharmaceutical Chemistry and Technologies, Pharmacy, and Biotechnologies.
RESEARCH ACTIVITY
Dr. Concettina Cappadone's research activity focuses on the study of proliferation and differentiation of normal and cancer cells. Her work has mainly focused on the antiproliferative effects of lipoperoxidation products, particularly 9-hydroxystearic acid and 4-hydroxy-nonenal. During her Ph.D., she participated in the development of a new analytical method to determine 4-HNE in human leukemia cells. She then studied the antitumor activity of novel indole derivatives or guanyl-hydrazones in different cancer cell lines. Furthermore, she evaluated the revertant activity of novel polycyclic or coumarin derivatives on multidrug-resistant cells. Characterization of cytotoxic and/or revertant activity was performed by fluorescence techniques (cytofluorimetry, confocal microscopy, spectrofluorimetry). Since the year 2012, she has been interested in analytical methods to quantify intracellular magnesium content, focusing her interest on the characterization and biological applications of novel cationic biosensors. The study extended to cellular magnesium homeostasis and its role in various cellular processes, particularly in cell cycle progression, apoptosis and differentiation.Recently, she has become interested in the analysis of magnesium on a single cell using X-ray fluorescence and synchrotron light to obtain complex elemental maps that include other fundamental elements in cell biochemistry (zinc, calcium and phosphorus). The study of the early stages of osteoblastic differentiation, both in mesenchymal stem cells and in human osteosarcoma-derived cells, has made it possible to verify the presence of zinc and magnesium as early as the first cores of bone biomineralization, adding a new element to the complex picture of osteogenesis.
Dr. Concettina Cappadone's research activity is documented by more than 50 publications in peer reviewed journals and more than 60 communications at national and international conferences.
SCIENTIFIC AND EDITORIAL MEMBERSHIP
Italian Society of Biochemistry (SIB), International Society for the Development of Research on Magnesium (SDRM); Association of Cell Biology and Differentiation (ABCD).
REVIEWER ACTIVITY
Reviewer for Anti-Cancer Agents in Medicinal Chemistry,, International Journal of Molecular Sciences, Nutrients, Scientific Report,Naunyn-Schmiedeberg's Archives of Pharmacology
