Foto del docente

Claudio Trombini

Full Professor

Department of Chemistry "Giacomo Ciamician"

Academic discipline: CHIM/06 Organic Chemistry


Keywords: stereocontrolled reactions Antimalarial and antiLeishmania bioactive molecules organocatalysis Synthesis of molecules useful in chemical sensing

Scientific Interests

The expertise in applied organic chemistry and sustainable approaches to organic synthesis is now focused on the following topics:

1) Synthesis of bioactive molecules, in particular of new antimalarial hits.

2) Synthesis of sensors for bioanalytical applications.

3) Development of new catalysts and experimental procedures in organocatalysis and organometallic catalysis.

  • Design and development of new organometallic reagents. A novel class of alfa-hydroxyallylating agents developed in our lab will be applied to the total synthesis of bioactive molecules, such as fungicides and antibiotics.
  • Synthesis of bioactive molecules. As an example, a new synthesis has been developed of 3,4,6-trisunstituted 1,2-dioxanes, whose biological activity against Plasmodium falciparum strains has been assessed.
  • New sustainable chemical processes. Known syntheses will be re-examined on the basis of eco-compatibility concepts. The reduction of energy consumption by using microwave heating, the reduction of chemical wastes by adopting solvent-less conditions or water as solvent, the use of ionic liquids as non volatile solvents are examples of technologies under development in our lab. For example, a new microwave-promoted approach to azacrowns modified with two hydroxyquinoline substituents has been developed. The new ligands have been used for sensing magnesium directly in cells. 
  • Design and synthesis of task-specific ionic liquids in organocatalysis and in metal-promoted catalysis. Over the last two years the most explored field in our lab was the design of metal-based catalysts and organocatalysts capable to work under sustainable conditions, e.g. in ionic liquids, in water or in aqueous biphasic conditions. Our strategy involves the installation of a permanent ionic group into the skeleton of known catalysts in such a way to combine efficiency and stereoselectivity with the catalyst recyclability, ensured by an efficient trapping of the catalyst in the ionic liquid or aqueous phase.