Foto del docente

Cecilia Garofalo

Adjunct professor

Department of Pharmacy and Biotechnology

Publications

  1. Agnoletto C., Pignochino Y., Caruso C and Garofalo CExosome-Based Liquid Biopsy Approaches in Bone and Soft Tissue Sarcomas: Review of the Literature, Prospectives, and Hopes for Clinical Application.Int. J. Mol. Sci.2023, 24(6), 5159. doi.org/10.3390/ijms24065159
  2. Minopoli M, Sarno S, Cannella L, Tafuto S, Scognamiglio G, Gallo M, Fazioli F, Azzaro R, Apice G, De Angelis B, Tamborini E, Garofalo C, Pignochino Y, Mercatali L, Ibrahim T, Falcioni R, Valenti B, Maestro R, Scotlandi K, De Chiara A, Carriero MV. Crosstalk between Macrophages and Myxoid Liposarcoma Cells Increases Spreading and Invasiveness of Tumor Cells. Cancers (Basel). 2021 Jun 30;13(13):3298. doi: 10.3390/cancers13133298.
  3. Agnoletto C., Caruso C and Garofalo C. Heterogeneous Circulating Tumor Cells in Sarcoma: Implication for Clinical Practice. Cancers (Basel) 2021 May 2;13(9):2189. doi: 10.3390/cancers13092189
  4. Caruso C and Garofalo C. Pharmacogenomics Biomarkers of Soft Tissue Sarcoma Therapies. Front Oncol. 2020 Apr 15;10:509. doi:10.3389/fonc.2020.00509. eCollection 2020. Review. PMID: 32351891
  5. Racanelli D, Brenca M, Baldazzi D, Goeman F, Casini B, De Angelis B, Guercio M, Milano GM, Tamborini E, Busico A, Dagrada G, Garofalo C, Caruso C, Brunello A, Pignochino Y, Berrino E, Grignani G, Scotlandi K, Parra A, Hattinger CM, Ibrahim T, Mercatali L, De Vita A, Carriero MV, Pallocca M, Loria R, Covello R, Sbaraglia M, Dei Tos AP, Falcioni R, Maestro R. Next-Generation Sequencing Approaches for the Identification of Pathognomonic Fusion Transcripts in Sarcomas: The Experience of the Italian ACC Sarcoma Working Group. .Front Oncol. 2020 Apr 15;10:489. doi: 10.3389/fonc.2020.00489. eCollection 2020.PMID:32351889
  6. Mattioli E, Andrenacci D, Garofalo C, Prencipe S, Scotlandi K, Remondini D,Gentilini D, Di Blasio AM, Valente S, Scarano E, Cicchilitti L, Piaggio G, Mai A, Lattanzi G. Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. Aging Cell. 2018 Aug 15:e12824. Doi: 10.1111/acel.12824. [Epub ahead of print] PubMed PMID: 30109767.
  7. Ratti C, Botti L, Cancila V, Galvan S, Torselli I, Garofalo C, Manara MC, Bongiovanni L, Valenti CF, Burocchi A, Parenza M, Cappetti B, Sangaletti S, Tripodo C, Scotlandi K, Colombo MP, Chiodoni C. Trabectedin overrides osteosarcoma differentiative block and reprograms the tumor immune enviroment enabling effective combination with immune checkpoint inhibitors Clin Cancer Res. 2017 Jun 9. pii: clincanres.3186.2016. doi: 10.1158/1078-0432.CCR-16-3186. [Epub ahead of print] PubMed PMID: 28600479.
  8. Mancarella C, Casanova-Salas I, Calatrava A, García-Flores M, Garofalo C, Grilli A, Rubio-Briones J, Scotlandi K, López-Guerrero JA. Insulin-like growth factor 1 receptor affects the survival of primary prostate cancer patients depending on TMPRSS2-ERG status. BMC Cancer. 2017 May 25;17(1):367. doi: 10.1186/s12885-017-3356-8. PubMed PMID: 28545426; PubMed Central PMCID: PMC5445474.
  9. Garofalo C, Capristo M, Mancarella C, Reuveni H, Picci P, and Scotlandi K. Preclinical Effectiveness of selective inhibitor of IRS1/2 NT157 in osteosarcoma cell lines. Front Endocrinol (Lausanne). 2015 May 13;6:74. doi:10.3389/fendo.2015.00074. eCollection 2015. PubMed PMID: 26029165; PubMed Central PMCID: PMC4429561.
  10. Amaral AT*, Garofalo C*, Frapolli R, Manara MC, Mancarella C, Uboldi S, Di Giandomenico S, Ordóñez JL, Sevillano V, Malaguarnera R, Picci P, Hassan AB, De Alava E, D'Incalci M, Scotlandi K. Trabectedin efficacy in Ewing sarcoma is greatly increased by combination with anti-IGF signaling agents. Clin Cancer Res. 2015 Jan 21. pii: clincanres.1688.2014. [Epub ahead of print] PubMed PMID: 25609059.
  11. Mancarella C, Casanova-Salas I, Calatrava A, Ventura S, Garofalo C, Rubio-Briones J, Magistroni V, Manara MC, López-Guerrero JA and Scotlandi K. ERG deregulation induces IGF-1R expression in prostate cancer cells and affects sensitivity to anti-IGF-1R agents. ONCOTARGET 03/2015; DOI:10.18632/oncotarget.3425.
  12. Garofalo C, Capristo M , Manara MC, Mancarella C, Landuzzi L, Belfiore A, Lollini P-L, Picci P, and Scotlandi K. Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug. PLoS One. 2013 Dec 31;8(12):e83832.
  13.  Garofalo C, Mancarella C, Grilli A, Manara MC, Astolfi A, Marino MT, Conte A, Sigismund S, Carè A, Belfiore A, Picci P, Scotlandi K. Identification of Common and Distinctive Mechanisms of Resistance to Different Anti-IGF-IR Agents in Ewing's Sarcoma. Mol Endocrinol. 2012 Sep;26(9):1603-16. Epub 2012 Jul 13.
  14. Manara MC, Garofalo C, Picci P, Ferrari S, Belfiore A, Scotlandi K. Designing novel therapies against sarcomas in the era of personalized medicine and economic crisis. CURRENT PHARMACEUTICAL DESIGN 2013 Volume: 19 Issue: 30 Pages: 5344-5361
  15. Scotlandi K, Manara MC, Serra M, Marino MT, Ventura S, Garofalo C, Alberghini M, Magagnoli G, Ferrari S, Lopez-Guerrero JA, Llombard-Bosch A, Picci P. Expression of insulinlike growth factor system components in Ewing's sarcoma and their association with survival. Eur J Cancer. 2011 Feb 21. [Epub ahead of print]
  16. Garofalo C, Manara MC, Nicoletti G, Marino MT, Lollini PL, Astolfi A, Pandini G, López-Guerrero JA, Schaefer KL, Belfiore A, Picci P, Scotlandi K. Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling. Oncogene. 2011 Jan 31. [Epub ahead of print] PubMed
  17. Lanzino M, Sisci D, Morelli C, Garofalo C, Catalano S, Casaburi I, Capparelli C, Giordano C, Giordano F, Maggiolini M, Andò S. Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells--identification of a novel androgen response element. Nucleic Acids Res. 2010 Apr 26. [Epub ahead of print]
  18. Rocchi A, Manara MC, Sciandra M, Zambelli D, Nardi F, Nicoletti G, Garofalo C, Meschini S, Astolfi A, Colombo MP, Lessnick SL, Picci P, Scotlandi K. CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis J Clin Invest. 2010 Mar;120(3):668-80. doi: 10.1172/JCI36667. Epub 2010 Feb 8
  19. Morelli C, Lanzino M, Garofalo C, Maris P, Brunelli E, Casaburi I, Catalano S, Bruno R, Sisci D, Andò S. Akt2 inhibition enables the Forkhead transcription factor FoxO3a to a repressive role for ER{alpha} transcriptional activity in breast cancer cells. Mol Cell Biol. 2009 Nov 23. [Epub ahead of print]
  20. Lanzino M*., Garofalo C*, Morelli C., Le Pera M., Zupo S, Mc Phaul MJ., Surmacz E, , Andò S, and Sisci D. Insulin Receptor Substrate 1 modulates the trancriptional activity and turnover of Androgen Receptor in breast cancer.  Breast Cancer Res Treat. 2008 Jun 4. [Epub ahead of print]
  21. Lanzino M, Morelli C, Garofalo C, Panno ML, Mauro L, Andò S, Sisci D Interaction between estrogen receptor alpha and insulin/IGF signaling in breast cancer. Curr Cancer Drug Targets. 2008 Nov;8(7):597-610.
  22. Sisci D, Morelli C, Cascio S, Lanzino M, Garofalo C, Reiss K, Garcia M, Russo A, Andò S and Surmacz E. The estrogen receptor a:insulin receptor substrate 1 complex in breast cancer: structure-function relationships. Ann Oncol. 2007 Jun;18 Suppl 6:vi81-5.
  23. Cascio S, Bartella V, Garofalo C, Russo A, Giordano A, Surmacz E. Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer cells. J Biol Chem. 2007 Feb 9;282(6):3498-506. Epub 2006 Dec 13.
  24. Sisci D, Morelli C, Garofalo C, Romeo F, Morabito L, Casaburi F, Middea E, Cascio S, Ando’ S and Surmacz E. Expression of nuclear insulin receptor substrate 1 (IRS-1) in breast cancer. J Clin Pathol. 2007 Jun;60(6):633-41. Epub 2006 Aug 1.
  25. Garofalo C*, Koda M*, Cascio S, Sulkowska M, Kanczuga-Koda L, Golaszewska J, Russo A, Sulkowski S and Surmacz E. Increased Expression of Leptin and the Leptin Receptor as a Marker of Breast Cancer Progression: Possible Role of Obesity-related Stimuli. Clin Cancer Res. 2006,vol 12,1447-1453,March 2006 .
  26. Cesarone G, Garofalo C, Abrams M, Igoucheva O, Alexeev V, Yoon K, Surmacz E and Wickstrom E. RNAi-mediated Silencing of Insulin Receptor Substrate 1 (IRS-1) Enhances Tamoxifen-Induced Cell Death in MCF-7 Breast Cancer Cells. J Cell Biochem. 2006 May 15;98(2):440-50.
  27. Garofalo C and Surmacz E. Leptin and Cancer. J. Cell. Physiol. 2006 Apr;207(1):12-22
  28. Chen J, Wu A, Sun H, Drakas R, Garofalo C, Cascio S, Surmacz E and Baserga R. Functional significance of IGF-1 mediated nuclear translocation of the insulin receptor substrate- 1 and beta-catenin. J. Biol Chem. 2005 Aug 19;280(33):29912-20. Epub 2005 Jun 20.
  29. Garofalo C, Sisci D, Surmacz E. Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res. 2004 Oct 1;10(19):6466-75.
  30. Morelli C*, Garofalo C*, Sisci D, del Rincon S, Cascio S, Tu X, Vecchione A, Sauter ER, Miller WH Jr, Surmacz E. Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters. Oncogene. 2004 Sep 30;23(45):7517-26.
  31. Sauter ER, Garofalo C, Hewett J, Hewett JE, Morelli C, Surmacz E. Leptin expression in breast nipple aspirate fluid (NAF) and serum is influenced by body mass index (BMI) but not by the presence of breast cancer. Horm Metab Res. 2004 May;36(5):336-40.
  32. Bonofiglio D, Garofalo C, Catalano S, Marsico S, Aquila S, Ando S. Low calcium intake is associated with decreased adrenal androgens and reduced bone age in premenarcheal girls in the last pubertal stages. J Bone Miner Metab. 2004;22(1):64-70.
  33. Koda M, Sulkowski S, Garofalo C, Kanczuga-Koda L, Sulkowska M, Surmacz E. Expression of the insulin-like growth factor-I receptor in primary breast cancer and lymph node metastases: correlations with estrogen receptors alpha and beta. Horm Metab Res. 2003 Nov-Dec;35(11-12):794-801.
  34. Morelli C, Garofalo C, Bartucci M, Surmacz E.Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells. Oncogene. 2003 Jun 26;22(26):4007-16.
  35. Bouttier S, Fourniat J, Garofalo C, Gleye C, Laurens A, Hocquemiller R. Beta-Lactamase Inhibitors from Anacardium occidentale Pharmaceutical Biology 2002 May; 40(3):231 – 234

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