Foto del docente

Carmela Fimognari

Associate Professor

Department for Life Quality Studies

Academic discipline: BIO/14 Pharmacology

Coordinator of PhD Programme of Science and Culture of Well-being and Lifestyles

Research

Keywords: antitumor chemotherapy chemoprevention carcinogenesis molecular mechanisms cellular mechanisms

Research topics are:
1) Antitumor Pharmacology
- Identification of plant-derived compounds with potential cancer chemopreventive activity and definition of their mechanism of action at cellular and molecular levels on different cell models (in vitro, in vivo and ex vivo).
- Preclinical development of phytochemicals as antitumor drugs.

2) Cellular and Genetic Toxicology
- Investigation of critical cellular and molecular events related to carcinogenesis induced by exposure to xenobiotics (drugs, phytochemicals, pesticides, etc.).
- Study of the risk of cancer in exposed populations by using biomarkers of effect.

Technical experience includes a wide range of genotoxicity tests, different techniques of molecular cytogenetics (FISH), several flow cytometric techniques for the analysis of different cellular and molecular events (genetic damage, apoptosis, necrosis, cell cycle, cell proliferation, levels of proteins involved in different cellular pathways), capillary electrophoresis.