Dr Lorenzini focus is on the cellular mechanisms that
ensure longevity and on the extracellular and intracellular
signaling that regulate them. In the laboratory of Dr Vincent
Cristofalo he has focused on intercellular signaling regulating
cell proliferation and senescence and on the differential
proliferative capacity of mammals and how this correlate with life
span. With Dr Christian Sell at Drexel University, he has
investigated the endocrine modulation of longevity trying to
separate the influence of GH from that of IGF-1. Now he operate in
Department of Biomedical and Neuromotor Sciences of the University
of Bologna where his main research focus is the understanding of
how DNA damage signaling interact with cell cycle progression. For
this aim he is exploiting the comparative approach using a cell
bank of mammals with different longevity.
1- therole of cell cycle check-point in
genomic stability and longevity.
At the cellular level, damage repair and
cell cycle arrest are interrelated, allowing sufficient time for
repair prior to cell cycle progression. Organisms have evolved so
that developmental timing is linked to environmental conditions,
such as nutrient availability and predation. Recent results
regarding species-specific differences in how cells handle DNA
damage, suggest that a stable cell cycle arrest is a feature of
long-lived species. The implication of these results is that
long-lived species delay cell cycle progression to a greater degree
than short-lived species, allowing for higher fidelity repair. In
other words the ability to devote longer periods of time to repair
and maintenance could be a key feature of long-lived species. The
capacity to finely tune DNA repair with the possibility of resuming
cell division, could be a determinant of species lifespan. For
more details see (1) and (2)
2- Role of lifestyle on health-span.
For more details see (3) and (4)
1. Fink LS, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia
S, Lorenzini A, Sell C. 53BP1 contributes to a robust genomic
stability in human fibroblasts.Aging (Albany NY), 2011
2. Antonello Lorenzini, Thomas Stamato and Christian Sell.
The disposable soma theory revisited: Time as a resource in the
theories of aging. Cell Cycle, 2011, 10, Issue 22, Nov.15.
3. F. Pasqui, M. Baldini, A. Lorenzini, A. Bordoni, M.
Malaguti et al., Evaluation of some nutritional and sport aspects
in sedentary and active adolescents: analysis in Italian and
Rumanian school, Progress in Nutrition, 2009, 11, pp. 47 –
4. D. Tiso, M. Baldini, N. Piaggesi, P. Ferrari, P. Biagi, M.
Malaguti, A. Lorenzini, “7 days for my health” A new tool to
evaluate kids' lifestyle. AgroFood industry hi-tech, 2010,
21 n. 3, pp. 47-50