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Alfonso Iorio

Full Professor

Department of Medical and Surgical Sciences

Academic discipline: MEDS-05/A Internal Medicine

Publications

  1. Frederico Germini,Carlo Cossa, Elisabetta Trinari, Emma Iserman, Quazi Ibrahim, Drashti Pete, Arun Keepanasseril, David Page, Mark W. Skinner, Alfonso Iorio, Feasibility of Administering the Patient Reported Outcomes, Burdens and Experiences (PROBE) Questionnaire Through the Canadian Bleeding Disorders Registry (CBDR) and Comparison of Data From the Two Sources.” Haemophilia (2025): https://doi.org/10.1111/hae.70117
  2. Paul Whaley, Brian S. Alper, Joanne Dehnbostel, Carlos Alva-Diaz, Stavros A. Antoniou, Antonio Bognanni, Javier Bracchiglione, Therese Kristine Dalsbø, Sean Grant, Jennifer Hunter, Alfonso Iorio, Malgorzata Lagisz, Harold Lehmann, Sheyu Li, Joerg J. Meerpohl, Saphia Mokrane, Cauê F. Monaco, Ignacio Neumann, Kevin Pottie, Shahab Sayfi, Nigar Sekercioglu, Jasvinder A. Singh, Bernardo Sousa-Pinto, Janice Tufte, Lenny Thinagaran Vasanthan, Li Wang, Jun Xia, Xiaomei Yao, Holger Schünemann, GRADE Concept Paper 9: Rationale and process for creating a GRADE Ontology, Journal of Clinical Epidemiology, 2025, 111921, ISSN 0895-4356, https://doi.org/10.1016/j.jclinepi.2025.111921 .
  3. Guyatt G, Zeng L, Brignardello-Petersen R, Prasad M, De Beer H, Murad MH, Iorio A, Agarwal A, Yao L, Agoritsas T, Rylance J, Mustafa RA, Vandvik PO, Eachempati P, Zhai C, Zhang L, Montori VM, Hultcrantz M. Core GRADE 2: choosing the target of certainty rating and assessing imprecision. BMJ. 2025 Apr 29;389:e081904. doi: 10.1136/bmj-2024-081904. PMID: 40300802.
  4. Guyatt G, Agoritsas T, Brignardello-Petersen R, Mustafa RA, Rylance J, Foroutan F, Prasad M, Agarwal A, De Beer H, Murad MH, Schandelmaier S, Iorio A, Yao L, Jaeschke R, Vandvik PO, Zeng L, Parpia S, D'Souza R, Rind D, Chu DK, Eachempati P, Prasad K, Hultcrantz M, Montori VM. Core GRADE 1: overview of the Core GRADE approach. BMJ. 2025 Apr 22;389:e081903. doi: 10.1136/bmj-2024-081903. PMID: 40262844.
  5. Zhou F, Parrish R, Afzal M, Saha A, Haynes RB, Iorio A, Lokker C. Benchmarking domain-specific pretrained language models to identify the best model for methodological rigor in clinical studies. J Biomed Inform. 2025 Jun;166:104825. doi: 10.1016/j.jbi.2025.104825. Epub 2025 Apr 15. PMID: 40246186.
  6. Guyatt G, Hultcrantz M, Agoritsas T, Iorio A, Vandvik PO, Montori VM. Why Core GRADE is needed: introduction to a new series in The BMJ. BMJ. 2025 Apr 15;389:e081902. doi: 10.1136/bmj-2024-081902. PMID: 40233981.
  7. Hirniak S, Edginton AN, Iorio A, Wong WWL. A Hemophilia Joint Health Score-Based Model for the Economic Evaluation of Hemophilia A Prophylaxis Interventions. Pharmacoeconomics. 2025 Apr 1. doi: 10.1007/s40273-025-01484-1. Epub ahead of print. PMID: 40167950.
  8. Iorio A, Laine C. What You May Have Missed in 2024: Navigating New Medical Evidence. Ann Intern Med. 2025 May;178(5_Supplement):S1. doi: 10.7326/ANNALS-25-01164. Epub 2025 Apr 1. PMID: 40163887.
  9. Chelle P, Hajducek D, Iserman E, Iorio A, Edginton A; International Prophylaxis Study Group. Exploring the Impact of Laboratory Reagents on Pharmacokinetic Profiling. Haemophilia. 2025 Mar 7. doi: 10.1111/hae.70021. Epub ahead of print. PMID: 40052423.
  10. Ng JY, Liu H, Masood M, Farin R, Messih M, Perez A, Aalbersberg IJ, Alperin J, Bryson GL, Chen Q, Ehrlich A, Iorio A, Meester WJN, Willinsky J, Grudniewicz A, Cobo E, Cranston I, Cress PE, Gunn J, Haynes RB, Keenoo BS, Marušić A, Papas ER, Purvis A, Segundo JDB, Shankar PR, Stoev P, Weisflog J, Winker M, Cobey KD, Moher D. Publisher preferences for a journal transparency tool: A modified three-round Delphi study. F1000Res. 2025 Jan 31;13:915. doi: 10.12688/f1000research.154408.2. PMID: 40046244; PMCID: PMC11880752.
  11. Zeng L, Hultcrantz M, Tovey D, Santesso N, Dahm P, Brignardello-Petersen R, Mustafa RA, Murad MH, Izcovich A, de Beer H, Ragusa MA, Johnston B, Zhang L, Iorio A, Guyatt G. Rating certainty when the target threshold is the null and the point estimate is close to the null. BMJ Evid Based Med. 2025 May 20;30(3):202-207. doi: 10.1136/bmjebm-2024-113077. PMID: 40044276.
  12. Ng JY, Maduranayagam SG, Suthakar N, Li A, Lokker C, Iorio A, Haynes RB, Moher D. Attitudes and perceptions of medical researchers towards the use of artificial intelligence chatbots in the scientific process: an international cross-sectional survey. Lancet Digit Health. 2024 Nov 15:S2589-7500(24)00202-4. doi: 10.1016/S2589-7500(24)00202-4. Epub ahead of print. PMID: 39550312.
  13. Lokker C, McKibbon KA, Afzal M, Navarro T, Linkins LA, Haynes RB, Iorio A. The McMaster Health Information Research Unit: Over a Quarter-Century of Health Informatics Supporting Evidence-Based Medicine. J Med Internet Res. 2024 Jul 31;26:e58764. doi: 10.2196/58764. PMID: 39083765.
  14. Kim MS, Hajducek DM, Gilbert JC, Iorio A, Jilma B, Edginton AN. Kinetic Modeling for BT200 to Predict the Level of Plasma-Derived Coagulation Factor VIII in Humans. AAPS J. 2024 Jul 12;26(4):81. doi: 10.1208/s12248-024-00952-4. PMID: 38992298.
  15. The Chart Collaborative. Protocol for the development of the Chatbot Assessment Reporting Tool (CHART) for clinical advice. BMJ Open2024;14:e081155. doi: 10.1136/bmjopen-2023-081155
  16. Hajducek DM, Chelle P, Iorio A, Iserman E, Edginton AN. Estimated prophylactic dose required to achieve 3% trough as a function of age and concentrate class in multi-country severe WAPPS-Hemo haemophilia patients. Haemophilia. 2024; 30: 925–932. https://doi.org/10.1111/hae.15032
  17. Piggott T, Moja L, Jenei K, Kredo T, Skoetz N, Banzi R, Trapani D, Leong T, McCaul M, Lavis JN, Akl EA, Nonino F, Iorio A, Laurson-Doube J, Huttner BD, Schünemann HJ. GRADE Concept 7: Issues and Insights Linking Guideline Recommendations to Trustworthy Essential Medicine Lists. J Clin Epidemiol. 2024 Feb;166:111241. doi: 10.1016/j.jclinepi.2023.111241. Epub 2023 Dec 19. PMID: 38123105; PMCID: PMC10939133.
  18. Foroutan F, Mayer M, Guyatt G, Riley RD, Mustafa R, Kreuzberger N, Skoetz N, Darzi A, Alba AC, Mowbray F, Rayner DG, Schunemann H, Iorio A. GRADE concept paper 8: judging the certainty of discrimination performance estimates of prognostic models in a body of validation studies. J Clin Epidemiol. 2024 Apr 3;170:111344. doi: 10.1016/j.jclinepi.2024.111344. Epub ahead of print. PMID: 38579978.
  19. Srivastava A, Iorio A. Lower-dose emicizumab prophylaxis: can less be more? J Thromb Haemost. 2024 Apr;22(4):922-925. doi: 10.1016/j.jtha.2024.01.018. PMID: 38521578.
  20. Hirniak S, Edginton AN, Iorio A, Alsabbagh MW, Hajducek DM, Wong WW. Health utilities in adults with hemophilia A: A retrospective cohort study. Haemophilia. 2024 Mar 20. doi: 10.1111/hae.14979. Epub ahead of print. PMID: 38506967.
  21. Curtis R, Wu J, Iorio A, Frick N, Nichol M, Noone D, O'Mahony B, Page D, Stonebraker J, Kucher A, Clearfield E, Skinner MW, Germini F. Test-retest reliability of a mobile application of the patient reported outcomes burdens and experiences (PROBE) study. Haemophilia. 2024 Mar 4. doi: 10.1111/hae.14969. Epub ahead of print. PMID: 38439137.

  22. Matino D, Germini F, Chan AKC, Decker K, Iserman E, Chelle P, Edginton AN, Oladoyinbo O, Trinari E, Keepanasseril A, Iorio A. Canadian clinical experience on switching from standard half-life recombinant factor VIII (rFVIII), octocog alfa, to extended half-life rFVIII, damoctocog alfa pegol, in persons with haemophilia A ≥ 12 years followed in a Comprehensive Hemophilia Care Program in Canada. Haemophilia. 2024 Mar;30(2):345-354. doi: 10.1111/hae.14960. Epub 2024 Feb 20. PMID: 38379181

  23. Sun HL, Yang M, Poon MC, Lee A, Robinson KS, Sholzberg M, Wu J, Iorio A, Blanchette V, Carcao M, Klaassen RJ, Jackson S. Factor product utilization and health outcomes in patients with haemophilia A and B on extended half-life concentrates: A Canadian observational study of real-world outcomes. Haemophilia. 2024 Sep;27(5):751-759. doi: 10.1111/hae.14369. Epub 2021 Jun 23. PMID: 34160870.

  24. Coffin D, Gouider E, Konkle B, Hermans C, Lambert C, Diop S, Ayoub E, Tootoonchian E, Youttananukorn T, Dakik P, Pereira T, Iorio A, Pierce GF; World Bleeding Disorders Registry Participating Investigators. The World Federation of Hemophilia World Bleeding Disorders Registry: insights from the first 10,000 patients. Res Pract Thromb Haemost. 2023 Nov 20;7(8):102264. doi: 10.1016/j.rpth.2023.102264. PMID: 38193052; PMCID: PMC10772874.

  25. Fischer K, Lassila R, Peyvandi F Gatt A, Hollingsworth R, Lambert T, Kaczmarek R, Bettle A, Samji N, Rivard GÉ, Carcao M, Iorio A, Makris M; EUHASS and CHESS participants. Inhibitor development according to concentrate in severe hemophilia: reporting on 1392 Previously Untreated Patients from Europe and Canada. Res Pract Thromb Haemost. 2023 Nov 20;7(8):102265. doi: 10.1016/j.rpth.2023.102265. PMID: 38193044; PMCID: PMC10772871

  26. Coffin, Donna, Abdel Mohsen, M. et al. The World Federation of Hemophilia World Bleeding Disorders Registry: insights from the first 10,000 patients. Research and Practice in Thrombosis and Haemostasis, Volume 7, Issue 8, 102264 DOI:https://doi.org/10.1016/j.rpth.2023.102264

  27. Piggott T, Moja L, Jenei K, Kredo T, Skoetz N, Banzi R, Trapani D, Leong T, McCaul M, Lavis JN, Akl EA, Nonino F, Iorio A, Laurson-Doube J, Huttner BD, Schünemann HJ. Grading of recommendations, assessment, development and evaluations concept 7: issues and insights linking guideline recommendations to trustworthy essential medicine lists. J Clin Epidemiol. 2023 Dec 19;166:111241. doi: 10.1016/j.jclinepi.2023.111241. Epub ahead of print. PMID: 38123105.
  28. Olasupo OO, Nakar C, Haddix C, Matthew T, Matino D, Malec L, Mbuagbaw L, Tarride JE, Iorio A, Shapiro AD. Inhibitors in hemophilia: association with surgery plans and outcomes in a retrospective cohort study. Res Pract Thromb Haemost. 2023 Oct 14;7(7):102228. doi: 10.1016/j.rpth.2023.102228. PMID: 38077822; PMCID: PMC10704510.
  29. Wilson MG, Vélez CM, Lavis JN, Misinformation Living Evidence Synthesis Team. Impact of strategies to mitigate misinformation in diverse settings and populations: A protocol for a living evidence synthesis. BMJ Open 2023; 13(10).
  30. Ng, JY, Maduranayagam S, Lokker C, Iorio A, Haynes, FB, Moher, D. Attitudes and Perceptions of Medical Researchers Towards the Use of Artificial Intelligence Chatbots in the Scientific Process: A Protocol for a Cross-Sectional Survey. medRxiv 2023.07.26.23293211; doi: https://doi.org/10.1101/2023.07.26.2329321 .
  31. Shaver N, Katz M, Darko Asamoah G, Linkins LA, Abdelkader W, Beck A, Bennett A, Hughes SE, Smith M, Begin M, Coyle D, Piggott T, Kagina BM, Welch V, Colijn C, Earn DJD, El Emam K, Heffernan J, O'Brien SF, Wilson K, Collins E, Navarro T, Beyene J, Boutron I, Bowdish D, Cooper C, Costa A, Curran J, Griffith L, Hsu A, Grimshaw J, Langlois MA, Li X, Pham-Huy A, Raina P, Rubini M, Thabane L, Wang H, Xu L, Brouwers M, Horsley T, Lavis J, Iorio A, Little J. Protocol for a living evidence synthesis on variants of concern and COVID-19 vaccine effectiveness. Vaccine. 2023 Sep 15:S0264-410X(23)01065-4. doi: 10.1016/j.vaccine.2023.09.012. Epub ahead of print. PMID: 37718186.
  32. Mannucci PM, Kessler CM, Germini F, Nissen F, Ofori-Asenso R, Brocchieri C, Bendinelli S, Iorio A. Bleeding events in people with congenital haemophilia A without factor VIII inhibitors receiving prophylactic factor VIII treatment: A systematic literature review. Haemophilia. 2023 Jun 8. doi: 10.1111/hae.14803. Epub ahead of print.
  33. Stonebraker JS, Iorio A, Lavin M, Rezende SM, Srivastava A, Pierce GF, Coffin D, Tootoonchian E, Makris M. Reported prevalence of von Willebrand disease worldwide in relation to income classification. Haemophilia. 2023 Jun 5. doi: 10.1111/hae.14810. Epub ahead of print.
  34. Lokker C, Bagheri E, Abdelkader W, Parrish R, Afzal M, Navarro T, Cotoi C, Germini F, Linkins L, Brian Haynes R, Chu L, Iorio A. Deep Learning to Refine the Identification of High-Quality Clinical Research Articles from the Biomedical Literature: Performance Evaluation. J Biomed Inform. 2023 Jun;142:104384. doi: 10.1016/j.jbi.2023.104384.
  35. Ng JY, Cobey KD, Ahmed S, Chow V, Maduranayagam SG, Santoro LJ, Sikora L, Marusic A, Shanahan D, Townsend R, Ehrlich A, Iorio A, Moher D. Recommendations and guidelines for creating scholarly biomedical journals: A scoping review. PLoS One. 2023;18(3):e0282168. doi: 10.1371/journal.pone.0282168.
  36. Iorio A, MacDonald V, Caillaud A, Luckevich MD, Christoffersen P, Matino D, Keepanasseril A, Iserman E, Germini F, Bentley A, Poon MC. Treatment switch to nonacog beta pegol factor IX in hemophilia B: A Canadian cost-consequence analysis based on real-world factor IX consumption and clinical outcomes. Res Pract Thromb Haemost. 2023;7(3):100106. doi: 10.1016/j.rpth.2023.100106.
  37. Gordon Guyatt, Yunli Zhao, Martin Mayer, Matthias Briel, Reem Mustafa, Ariel Izcovich, Monica Hultcrantz, Alfonso Iorio, Ana Carolina Alba, Farid Foroutan, Xin Sun, Holger Schunemann, Hans DeBeer, Elie A. Akl, Robin Christensen, Stefan Schandelmaier. GRADE guidance 36: updates to GRADE's approach to addressing inconsistency. Journal of Clinical Epidemiology. 2023;158:7-83.
  38. Ng JY, Cobey KD, Ahmed S, Chow V, Maduranayagam SG, Santoro LJ, Sikora L, Marusic A, Shanahan D, Townsend R, Ehrlich A, Iorio A, Moher D. Recommendations and guidelines for creating scholarly biomedical journals: A scoping review. [https://pubmed.ncbi.nlm.nih.gov/37000832/] PLoS One. 2023;18(3):e0282168. doi: 10.1371/journal.pone.0282168. eCollection 2023.
  39. Guyatt G, Zhao Y, Mayer M, Briel M, Mustafa R, Izcovich A, Hultcrantz M, Iorio A, Alba AC, Foroutan F, Sun X, Schunemann H, DeBeer H, Akl EA, Christensen R, Schandelmaier S. GRADE Guidance 36: Updates to GRADE's approach to addressing inconsistency. J Clin Epidemiol. 2023:S0895-4356(23)00046-X. doi: 10.1016/j.jclinepi.2023.03.003. Online ahead of print. PMID: 36898507
  40. von Drygalski A, Chowdary P, Kulkarni R, Susen S, Konkle BA, Oldenburg J, Matino D, Klamroth R, Weyand AC, Jimenez-Yuste V, Nogami K, Poloskey S, Winding B, Willemze A, Knobe K; XTEND-1 Trial Group. Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A. N Engl J Med. 2023 Jan 26;388(4):310-318.
  41. Yu JK, Wong WWL, Keepanasseril A, Iorio A, Edginton AN. Cost-utility analysis of emicizumab for the treatment of severe hemophilia A patients in Canada. Haemophilia. 2022 Dec 18 Haemophilia. 2023;29(2):488-497. doi: 10.1111/hae.14723.
  42. Dewidar O, Lotfi T, Langendam M, Parmelli E, Saz Parkinson Z, Solo K, Chu DK, Mathew JL, Akl EA, Brignardello-Petersen R, Mustafa RA, Moja L, Iorio A, Chi Y, Canelo-Aybar C, Kredo T, Karpusheff J, Turgeon AF, Alonso-Coello P, Wiercioch W, Gerritsen A, Klugar M, Rojas MX, Tugwell P, Welch VA, Pottie K, Munn Z, Nieuwlaat R, Ford N, Stevens A, Khabsa J, Nasir Z, Leontiadis GI, Meerpohl JJ, Piggott T, Qaseem A, Matthews M, Schünemann HJ; eCOVID-19 recommendations map collaborators. Which actionable statements qualify as good practice statements In Covid-19 guidelines? A systematic appraisal. BMJ Evid Based Med. 2022;27(6):361-369.
  43. Shapiro AD, Hardesty BM, Peyvandi F, Iorio A. Prevalence of selected bleeding and thrombotic events in persons with hemophilia versus the general population: A scoping review. [https://pubmed.ncbi.nlm.nih.gov/36891522/] Res Pract Thromb Haemost. 2022;7(1):100007. doi: 10.1016/j.rpth.2022.100007. eCollection 2023 Jan. PMID: 36891522
  44. Iorio A, Königs C, Reding MT, Rotellini D, Skinner MW, Mancuso ME, Berntorp E. Prophylaxis use of clotting factor replacement products in people with non-severe haemophilia: A review of the literature. Haemophilia. 2023 Jan;29(1):33-44. doi: 10.1111/hae.14676. Epub 2022 Oct 12. PMID: 36224704 Review.
  45. Ay C, Kovacevic KD, Kraemmer D, Schoergenhofer C, Gelbenegger G, Firbas CU, Quehenberger P, Jilma-Stohlawetz P, Gilbert JC, Zhu S, Beliveau M, Koenig F, Iorio A, Jilma B, Derhaschnig U, Pabinger I. von Willebrand Factor-binding aptamer rondoraptivon pegol as treatment for severe and non-severe hemophilia A. Blood. Blood. 2023;141(10):1147-1158. doi: 10.1182/blood.2022016571.
  46. Brignell A, Harwood RC, May T, Woolfenden S, Montgomery A, Iorio A, Williams K. Overall prognosis of preschool autism spectrum disorder diagnoses. Cochrane Database Syst Rev. 2022;9(9):CD012749. doi: 10.1002/14651858.CD012749.pub2.
  47. Li N, Mahamad S, Parpia S, Iorio A, Foroutan F, Heddle NM, Hsia CC, Sholzberg M, Rimmer E, Shivakumar S, Sun HL, Refaei M, Hamm C, Arnold DM. Development and internal validation of a clinical prediction model for the diagnosis of immune thrombocytopenia. J Thromb Haemost. 2022;20(12):2988-2997.
  48. Nummi, V, Lehtinen, A-E, Iorio, A, Szanto, T, Lassila, R. Switching from standard to extended half-life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics. Haemophilia. 2022;28(6):e237-e244.
  49. Chelle P, Iorio A, Edginton AN. A Personalized Limited Sampling Approach to Better Estimate Terminal Half-life of FVIII concentrates. J Thromb Haemost. 2022 Jun 26. doi: 10.1111/jth.15803. Online ahead of print. PMID: 35753074
  50. Linkins LA, Iorio A, Little J, Lavis J. Extended reporting guidance for vaccine effectiveness studies for variants of concern for COVID-19. Vaccine. 2022;40(22):2986-2987.
  51. Mahlangu J, Iorio A, Kenet G. Emicizumab state-of-the-art update. Haemophilia. 2022;28 Suppl 4:103-110. doi: 10.1111/hae.14524.
  52. Pottie, K., Smith, M., Matthews, M., Santesso, N., Magwood, O., Kredo, T., Scott, S., Bayliss, K., Saad, A., Haridas, R., Detambel, N., Motilall, A., Tan, Y., Steinberg, S., Litynska, J., Dietl, B., Ioiri, A., Reveiz, L., & Schünemann, H. J. A multistakeholder development process to prioritize and translate COVID-19 health recommendations for patients, caregivers and the public. A case study of the COVID-19 recommendation map. Journal of Clinical Epidemiology. 2022;148:104-114.
  53. Germini F, Noronha N, Abraham Philip B, Olasupo O, Pete D, Navarro T, Keepanasseril A, Matino D, de Wit K, Parpia S, Iorio A. Risk factors for bleeding in people living with hemophilia A and B treated with regular prophylaxis: A systematic review of the literature. J Thromb Haemost. 2022 Jun;20(6):1364-1375. doi: 10.1111/jth.15723.
  54. Bowman, M, Casey, L, Selvam, SN, Lima, D.A, Rawley O, Hinds M, Tuttle A, Grabell J, Iorio A, Walker I, Lillcrap D, James P. von Willebrand factor propeptide variants lead to impaired storage and ER retention in patient-derived endothelial colony-forming cells. J Thromb Haemost. 2022;20(7):1599-1609.
  55. Germini F, Noronha N, Borg Debono V, Abraham Philip B, Pete D, Navarro T, Keepanasseril A, Parpia S, de Wit K, Iorio A. Accuracy and Acceptability of Wrist-Wearable Activity-Tracking Devices: Systematic Review of the Literature. J Med Internet Res 2022;24(1):e30791.
  56. Nasir ZH, Mertz D, Nieuwlaat R, Santesso N, Lotfi T, Motilall A, Moja L, Mbuagbaw L, Klugar M, Turgeon AF, Mathew JL, Canelo-Aybar C, Pottie K, Dewidar O, Langendam MW, Iorio A, Vist GE, Meerpohl JJ, Flottorp S, Kredo T, Piggott T, Mathews M, Qaseem A, Chu DK, Tugwell P, Klugarová J, Nelson H, Hussein H, Suvada J, Neumann I, Schünemann HJ; eCOVID-19 recommendations map Collaborators. An evaluation of the eCOVID19 Recommendation Map identified diverging Clinical and Public Health guidance. J Clin Epidemiol. 2022;147:83-94.
  57. Versloot O, Iserman E, Chelle P, Germini F, Edginton AN, Schutgens REG, Iorio A, Fischer K. Predicting Individual Changes in Terminal Half-Life After Switching to Extended Half-Life Concentrates in Patients With Severe Hemophilia. Hemasphere. 2022 Mar 21;6(4):e694.
  58. Germini F, Borg Debono V, Page D, Zuk V, Kucher A, Cotoi C, Hobson N, Sevestre M, Skinner MW, Iorio A; PROBE Investigators. User-Centered Development and Testing of the Online Patient-Reported Outcomes, Burdens, and Experiences (PROBE) Survey and the myPROBE App and Integration With the Canadian Bleeding Disorder Registry: Mixed Methods Study. JMIR Hum Factors. 2022;9(1):e30797. doi: 10.2196/30797.
  59. Chelle P, Hajducek D, Mahdi M, Young S, Iorio A, Silvertown J, Edginton A. External qualification of the Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo) models for octocog alfa using real patient data. Res Pract Thromb Haemost. 2021;5(7):e12599. doi: 10.1002/rth2.12599.
  60. Wiercioch W, Nieuwlaat R, Zhang Y, Alonso-Coello P, Dahm P, Iorio A, Manja V, Mustafa RA, Neumann I, Ortel TL, Rochwerg B, Santesso N, Vesely SK, Akl EA, Schünemann HJ. New methods facilitated the process of prioritizing questions and health outcomes in guideline development. J Clin Epidemiol. 2021;143:91-104.
  61. Olasupo OO, Haddix C, Nakar C, Maahs J, Greist A, Ghafoor A, Donfield SM, Iorio a, Shapiro AD. Utilization of a surgical database to provide care and assess perioperative treatment and outcomes in patients with bleeding disorders. Eur J Haematol. 2021;00:1–12. doi:10.1111/ejh.13731
  62. Abdelkader W, Navarro T, Parrish R, Cotoi C, Germini F, Linkins LA, Iorio A, Haynes RB, Ananiadou S, Chu L, Lokker C. A Deep Learning Approach to Refine the Identification of High-Quality Clinical Research Articles From the Biomedical Literature: Protocol for Algorithm Development and Validation. JMIR Res Protoc. 2021;10(11):e29398. doi: 10.2196/29398.
  63. Lokker C, Gentles SJ, Ganann R, Jezrawi R, Tahir I, Okelana O, Yousif C, Iorio A, Valaitis R. Knowledge translation strategies for sharing evidence-based health information with older adults and their caregivers: findings from a persona-scenario method. BMC Geriatr. 2021;21(1):665. doi: 10.1186/s12877-021-02588-x.
  64. Blamey G, Van Tassel B, Sagermann E, Stain A,Waterhouse L, Iorio A. Sexual issues in people with haemophilia: awareness and strategies for overcoming communication barriers. Haemophilia. Haemophilia. 2022;28:36–41. https://doi.org/10.1111/hae.14447
  65. Foroutan F, Guyatt G, Trivella M, Kreuzberger N, Skoetz N, Riley RD, Roshanov PS, Alba AC, Sekercioglu N, Canelo C, Munn Z, Brignardello-Petersen R, Schünemann HJ, Iorio A. GRADE concept paper 2: Concepts for Judging Certainty on the Calibration of Prognostic Models in a Body of Validation Studies. J Clin Epidemiol. 2022;143:202-211.
  66. Lotfi T, Hajizadeh A, Moja L, Akl EA, Piggott T, Kredo T, Langendam MW, Iorio A, Klugar M, Klugarová J, Neumann I, Wiercioch W, Leontiadis GI, Mbuagbaw L, Turgeon AF, Meerpohl J, Stevens A, Brozek J, Santesso N, Pottie K, Dewidar O, Flottorp SA, Karpusheff J, Saz-Parkinson Z, Rojas MX, Parmelli E, Chu DK, Tugwell P, Welch V, Avey MT, Brignardello-Petersen R, Mathew JL, Munn Z, Nieuwlaat R, Ford N, Qaseem A, Askie LM, Schünemann HJ. A taxonomy and framework for identifying and developing actionable statements in guidelines suggests avoiding informal recommendations. J Clin Epidemiol. 2022;141:161-171.
  67. Germini F, Chai-Adisaksopha C, Pete D, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker JS, Thabane L, Crowther MA, Skinner MW, Iorio A. Evaluation of the sexual health in people living with hemophilia. Haemophilia. 2021;21:993-1001.
  68. Nieuwlaat R, Wiercioch W, Brożek JL, Santesso NAM, Kunkle R, Alonso-Coello P, Anderson DR, Bates S, Cushman M, Dahm P, Iorio A, Lim W, Lyman GH, Middeldorp S, Monagle P, Mustafa RA, Neumann I, Ortel T, Rochwerg B, Vesely SK, Witt DM, Cuker A, Schunemann HJ. How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines. Blood Adv. 2021;5(22):4721-4726. doi: 10.1182/bloodadvances.2020003577.
  69. Olasupo OO, Lowe MS, Krishan A, Collins P, Iorio A, Matino D. Clotting factor concentrates for preventing bleeding and bleeding-related complications in previously treated individuals with haemophilia A or B. Cochrane Database Syst Rev. 2021;8(8):CD014201. doi: 10.1002/14651858.CD014201.
  70. Abdelkader W, Navarro T, Parrish R, Cotoi C, GerminiF, Iorio A, Haynes RB, Lokker C. Machine Learning Approaches to Retrieve High-Quality, Clinically Relevant Evidence From the Biomedical Literature: Systematic Review. JMIR Med Inform. 2021;9(9):e30401. doi: 10.2196/30401.
  71. Stonebraker JS, O’Mahony B, Noone D, Iorio A. Converting factor and nonfactor usage into a single metric to facilitate benchmarking the resources consumed for haemophilia care across jurisdictions and over time. Haemophilia. 2021; 2021;27(5):e596-e608.
  72. Sun H, Yang M, Poon M-C, Lee A, Robinson KS, Sholzberg M, Wu J, Iorio A, Blanchette V, Carcao M, Klaassen RJ, Jackson S. Factor product utilization and health outcomes in patients with haemophilia A and B on extended half-life concentrates: A Canadian observational study of real-world outcomes. Haemophilia. 2021;27(5):751-759
  73. Wiercioch W, Nieuwlaat R, Dahm P, Iorio A, Mustafa RA, Neumann I, Rochwerg B, Manja V, Alonso-Coello P, Ortel TL, Santesso N, Vesely SK, Akl EA, Schünemann HJ, Bates SM, Cuker A, Lim W, Monagle P, Kunkle R, Witt DM, Kahn SR, McLintock C, Rezende SM, Zakai NA; ASH VTE Panels Working Group. Development and application of health outcome descriptors facilitated decision-making in the production of practice guidelines. J Clin Epidemiol. 2021;138:115-127.
  74. Versloot O, Iserman E, Chelle P, Germini F, Edginton AN, Schutgens REG, Iorio A, Fischer K; Pharmacokinetic (PK) Expert Working Group of the International Prophylaxis Study Group (IPSG). Terminal half-life of FVIII and FIX according to age, blood group and concentrate type: data from the WAPPS database. J Thromb Haemost. 2021;19:1896-1906.
  75. van Balen EC, O'Mahony B, Cnossen MH, Dolan G, Blanchette VS, Fischer K, Gue D, O'Hara J, Iorio A, Jackson S, Konkle BA, Nugent DJ, Coffin D, Skinner MW, Smit C, Srivastava A, van Eenennaam F, van der Bom JG, Gouw SC. Patient-relevant health outcomes for hemophilia care: Development of an international standard outcomes set. Res Pract Thromb Haemost. 2021;5(4):e12488. doi: 10.1002/rth2.12488.
  76. Spinella PC, El Kassar N, Cap AP, Kindzelski AL, Almond CS, Barkun A, Gernsheimer TB, Goldstein JN, Holcomb JB, Iorio A, Jensen DM, Key NS, Levy JH, Mayer SA, Moore EE, Stanworth SJ, Lewis RJ, Steiner ME; Hemostasis Trials Outcomes Working Group. Recommended Primary Outcomes for Clinical Trials Evaluating Hemostatic Blood Products and Agents in Patients with Bleeding: Proceedings of a National Heart Lung and Blood Institute and United States Department of Defense Consensus Conference. J Trauma Acute Care Surg. 2021 Aug 1;91(2S Suppl 2):S19-S25. doi: 10.1097/TA.0000000000003300.
  77. Astermark J, Olsson A, Chelle P, Täckström K, Walger M, Magnusson M, Iorio A. Comparison of single subject and population-based pharmacokinetics for optimizing prophylaxis with simoctocog alfa in patients with haemophilia A. Haemophilia . 2021;27(4):626-633.
  78. Teitel J, Sholzberg M, Iorio A. Extended half-life factor VIII concentrates in adults with hemophilia A: Comparative pharmacokinetics of two products. Res Pract Thromb Haemost. 2021 Feb 23;5(2):349-355.
  79. Aquino CC, Borg Debono V, Germini F, Pete D, Kempton CL, Young G, Sidonio R, Croteau SE, Dunn AL, Key NS, Iorio A. Outcomes for studies assessing the efficacy of hemostatic therapies in persons with congenital bleeding disorders. Haemophilia. 2021;27(2):211-220.
  80. Yu JK, Iorio A, Chelle P, Edginton AN. Pharmacokinetic implications of dosing emicizumab based on vial size: A simulation study. Haemophilia. 2021;27(3):358-365.
  81. Riva S, Marchesini E, Oliovecchio E, Coppola A, Santagostino E, Radossi P, Castaman G, Valdrè L, Santoro C, Tagliaferri A, Ettorre CP, Zanon E, Barillari G, Cantori I, Caimi TM, Sottilotta G, Iorio A, Mannucci PM. Comparison of quality of life, and emotional and functional profiles in older people with and without severe haemophilia. Haemophilia. 2021 Jul;27(4):e525-e529.
  82. Kavanagh PL, Frater F, Navarro T, LaVita P, Parrish R, Iorio A. Optimizing a literature surveillance strategy to retrieve sound overall prognosis and risk assessment model papers. J Am Med Inform Assoc. 2021;28(4):766-771. doi: 10.1093/jamia/ocaa232.
  83. Asamoah-Boaheng M, Badejo OA, Bell LV, Buckley N, Busse JW, Campbell TS, Corace K, Cooper L, Flusk D, Garcia DA, Hossain MA, Iorio A, Lavoie KL, Poulin PA, Skidmore B, Rash JA. Interventions to Influence Opioid Prescribing Practices for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis. Am J Prev Med. 2021;60(1):e15-e26. doi: 10.1016/j.amepre.2020.07.012.
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  85. Barco S, Valerio L, Ageno W, Cohen AT, Goldhaber SZ, Hunt BJ, Iorio A, Jimenez D, Klok FA, Kucher N, Mahmoudpour SH, Middeldorp S, Münzel T, Tagalakis V, Wendelboe AM, Konstantinides SV. Age-sex specific pulmonary embolism-related mortality in the USA and Canada, 2000-18: an analysis of the WHO Mortality Database and of the CDC Multiple Cause of Death database. Lancet Respir Med. 2021(1):33-42. doi: 10.1016/S2213-2600(20)30417-3.
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  87. Konkle B, Pierce G, Coffin D, Naccache M, Clark RC, George L, Iorio A, O'Mahony B, Pipe S, Skinner M, Watson C, Peyvandi F, Mahlangu J; ISTH subcommittee on Factor VIII, Factor IX, rare bleeding disorders. Core data set on safety, efficacy, and durability of hemophilia gene therapy for a global registry: Communication from the SSC of the ISTH. J Thromb Haemost. 2020;18(11):3074-3077.
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  97. Konkle BA, Coffin D, Pierce GF, Clark C, George L, Iorio A, Mahlangu J, Naccache M, O'Mahony B, Peyvandi F, Pipe S, Quartel A, Sawyer EK, Skinner MW, Tortella B, Watson C, Winburn I; Members of the WFH Gene Therapy Registery Steering Committee. World Federation of Hemophilia Gene Therapy Registry. Haemophilia. 2020 Jul;26(4):563-564. doi: 10.1111/hae.14015. Epub 2020 May 27. PMID: 32462720.
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  111. 112.Grimshaw JM, Tovey DI, Lavis JN, on behalf of COVID-END. COVID-END: an international network to better co-ordinate and maximize the impact of the global evidence synthesis and guidance response to COVID-19. In: Collaborating in response to COVID-19: editorial and methods initiatives across Cochrane. Cochrane Database of Systematic Reviews 2020;(12 Suppl 1):[4-8]. https://doi.org/10.1002/14651858.CD202002
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  117. 118.Pouplard C, Sattler L, Ryman A, Eschwege V, De Maistre E, Flaujac C, Szymezak J, Grand F, Repesse Y, Galinat H, Donnard M, Ternisien C, Iorio A, Chelle P, Jeanpierre E; ‘Biology Study Group on Haemorrhagic Diseases’ (Group BIMHO - GFHT). Multicentre pharmacokinetic evaluation of rFVIII-Fc (efmoroctocog alfa) in a real life and comparison with non-extended half-life FVII concentrates. Haemophilia. 2020. Mar;26(2):282-289. Doi: 10.1111/hae.13946. Epub 2020 Feb 27.
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  130. 131.Mahlangu, J., Naidoo, Y., Goga, Y., Vaithlingum, M., Joubert, J., Sutton, C., Potgieter, J., Cruickshank, A-L., Iorio A. Home therapy for inherited bleeding disorders in South Africa: Results of a modified Delphi consensus process. S Afr Med J. [https://www.ncbi.nlm.nih.gov/pubmed/?term=Home+therapy+for+inherited+bleeding+disorders+in+South+Africa%3A+Results+of+a+modified+Delphi+consensus+process.] 2019 Aug 28;109(9):639-644. doi: 10.7196/SAMJ.2019.v109i9.13637.

  131. 132.Shah, A, Solms A, Wiegmann S, Ahsman M, Berntorp E, Tiede A, Iorio A, Mancuso ME, Zhivkov T, Lissitchkov T. Direct comparison of two extended-half-life recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A. Ann Hematol. [https://www.ncbi.nlm.nih.gov/pubmed/?term=alfonso+iorio+shah] 2019 Sep;98(9):2035-2044. doi: 10.1007/s00277-019-03747-2.
  132. 133.Alper BS, Oettgen P, Kunnamo I, Iorio A, Ansari MT, Murad MH, Meerpohl JJ, Qaseem A, Hultcrantz M, Schünemann HJ, Guyatt G; GRADE Working Group. Defining certainty of net benefit: a GRADE concept paper. BMJ Open. 2019 Jn 4;9(6):e027445. Doi: 10.1136/bmjopen-2018-027445. PMID: 31167868 [PubMed – in process] Free PMC Article.
  133. 134.Alanna McEneny-King, Pierre Chelle, Gary Foster, Arun Keepanasseril, Alfonso Iorio, Andrea N. Edginton. Development and evaluation of generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization. Journal of Pharmacokinetics and Pharmacodynamics. 2019 May 18. doi: 10.1007/s10928-019-09634-7. [Epub ahead of print].
  134. 135.Yu JK, Iorio A, Edginton AN; WAPPS co-investigators. Using pharmacokinetics for tailoring prophylaxis in people with hemophilia switching between clotting factor products: A scoping review. Res Pract Thromb Haemost. 2019 May 20;3(3):528-541. Doi: 10.1002/rth2.12204. eCollection 2019 Jul. Review. Erratum in: Res Pract Thromb Haemost. 2019 Sep 16;3(4):771.
  135. 136.Carcao MD, Chelle P, Clarke E, Kim L, Tiseo L, Morfini M, Hossain T, Rand ML, Brown C, Edginton A, Lillicrap D, Iorio A, Blanchette VS. Comparative pharmacokinetics of two extended half-life FVIII concentrates (Eloctate and Adynovate) in adolescents with hemophilia A: is there a difference? J Thromb Haemost. 2019 Apr 30. doi: 10.1111/jth.14469. [Epub ahead of print] PubMed PMID: 31038793.
  136. 137.Escobar M, Santagostino E, Mancuso ME, Coppens M, Balasa V, Taylor JA, Iorio A, Negrier C. Switching patients in the age of long-acting recombinant products? Expert Rev Hematol. 2019;12(sup1):1-13. Doi: 10.1080/17474086.2018.1564032. PMID:31282771.
  137. 138.Konkle BA, Skinner M, Iorio A. Hemophilia trials in the twenty-first century: Defining patient important outcomes. Res Pract Thromb Haemost. 2019 Mar 12;3(2):184-192. doi: 10.1002/rth2.12195. eCollection 2019 Apr. Review. PubMed PMID: 31011702; PubMed Central PMCID: PMC6462740.
  138. 139.Ning S, Liu Y, Barty R, Cook R, Rochwerg B, Iorio A, Warkentin TE, Heddle NM, Arnold DM. The association between platelet transfusions and mortality in patients with critical illness. Transfusion. 2019 Apr 1. doi: 10.1111/trf.15277.[Epub ahead of print] PubMed PMID: 30934133.
  139. 140.Pai M, Yeung CHT, Akl EA, Darzi A, Hillis C, Legault K, Meerpohl JJ, Santesso N, Taruscio D, Verhovsek M, Schünemann HJ, Iorio A. Strategies for eliciting and synthesizing evidence for guidelines in rare diseases. BMC Med Res Methodol. 2019 Mar 28;19(1):67. doi: 10.1186/s12874-019-0713-0. PubMed PMID: 30922227; PubMed Central PMCID: PMC6437842.
  140. 141.Chai-Adisaksopha C, Skinner MW, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker J, Thabane L, Crowther MA, Iorio A. Exploring regional variations in the cross-cultural, international implementation of the Patient Reported Outcomes Burdens and Experience (PROBE) study. Haemophilia. 2019 Mar 12. doi: 10.1111/hae.13703. [Epub ahead of print] PubMed PMID: 30861270.
  141. 142.Peyvandi F, Castaman G, Gresele P, De Cristofaro R, Schinco P, Bertomoro A, Morfini M, Gamba G, Barillari G, Jiménez-Yuste V, Königs C, Iorio A, Federici AB. A phase III study comparing secondary long-term prophylaxis versus on-demand treatment with vWF/FVIII concentrates in severe inherited von Willebrand disease. Blood Transfus. 2019 Feb 4:1-8. doi: 10.2450/2019.0183-18. [Epub ahead of print] PubMed PMID: 30747707.
  142. 143.Haynes RB, Budhram D, Cherian J, Iserman E, Iorio A, Lokker C. An evidence rating service provided valid correlates of the clinical importance of medical articles and journals. J Clin Epidemiol. 2019 May;109:80-89. doi: 10.1016/j.jclinepi.2019.01.010. Epub 2019 Feb 5. PubMed PMID: 30731116.
  143. 144.Stemberger M, Kallenbach F, Schmit E, McEneny-King A, Germini F, Yeung CHT, Edginton AN, von Mackensen S, Kurnik K, Iorio A. Impact of Adopting Population Pharmacokinetics for Tailoring Prophylaxis in Haemophilia A Patients: A Historically Controlled Observational Study. Thromb Haemost. 2019 Mar;119(3):368-376. doi: 10.1055/s-0039-1677700. Epub 2019 Jan 27. PubMed PMID: 30685872.
  144. 145.Makris M, Iorio A. Prehospital fresh frozen plasma: Universal life saver or treatment in search of a target population? Res Pract Thromb Haemost. 2018 Dec 12;3(1):12-14. doi: 10.1002/rth2.12172. eCollection 2019 Jan. PubMed PMID: 30656270; PubMed Central PMCID: PMC6332771.
  145. 146.Chai-Adisaksopha C, Skinner MW, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker J, Thabane L, Crowther MA, Iorio A. Test-retest properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire and its constituent domains. Haemophilia. 2019 Jan;25(1):75-83. doi: 10.1111/hae.13649. Epub 2018 Dec 6. PubMed PMID: 30520534.
  146. 147.Amir Qaseem, Timothy J. Wilt, Devan Kansagara, Carrie Horwitch, Michael J. Barry, and Mary Ann Forciea for the Clinical Guidelines Committee of the American College of Physicians. Hemoglobin A1c Targets for Glycemic Control with Pharmacologic Therapy for Nonpregnant Adults with Type 2 Diabetes Mellitus: A Guidance Statement Update from the American College of Physicians. Ann Inter Med. 2018;168:569-576. Doi:10.7326/M17-0939.
  147. 148.Amir Qaseem, Jennifer Lin, Reem A. Mustafa, Carrie A. Horwitch and Timothy J. Wilt for the Clinical Guidelines Committee of the American College of Physicians. Screening for Breast Cancer in Average-Risk Women: A Guidance Statement from the American College of Physicians. Ann Intern Med. 2019 Apr 9. doi: 10.7326/M18-2147. [Epub ahead of print]
  148. 149.Legault K, Schunemann H, Hillis C, Yeung C, Akl EA, Carrier M, Cervera R, Crowther M, Dentali F, Erkan D, Espinosa G, Khamashta M, Meerpohl JJ, Moffat K, O’Brien S, Pengo V, Rand JH, Rodriguez Pinto I, Thom L, Iorio A. McMaster RARE-Best practices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome. Journal of Thrombosis and Haemostasis 2018; 16(8): 1656-64.
  149. 150.Patricia Poulin, Yaadwinder Shergill, Heather Romanow, Jason W. Busse, Christine T. Chambers, Lynn Cooper, Paula A. Forgeron, Anita Olsen Harper, Maria Hudspith, Alfonso Iorio, Chitra Lalloo, Carley Ouellette, Rosalind Robertson, Sandy Smeenk, Bonnie Stevens & Jennifer Stinson (2018) Researching what matters to improve chronic pain care in Canada: A priority-setting partnership process to support patient-oriented research, Canadian Journal of Pain, 2:1, 191-204, DOI: 10.1080/24740527.2018.1433959 To link to this article:https://doi.org/10.1080/24740527.2018.1433959.
  150. 151.Rash JA, Buckley N, Busse JW, Campbell TS, Corace K, Cooper L, Flusk D, Iorio A, Lavoie KL, Poulin PA, Skidmore B. Healthcare provider knowledge, attitudes, beliefs, and practices surrounding the prescription of opioids for chronic non-cancer pain in North America: a protocol for a mixed-method systematic review. Syst Rev. 2018 Nov 13:7(1): 189. Doi: 10.1186/s13643-018-0858-7. PMID: 30424800.
  151. 152.McEneny-King A, Chelle P, Iorio A, Edginton AN. The effect of unmeasurable endogenous plasma factor activity levels on factor VIII dosing in patients with severe hemophilia A. Thromb Res. 2018 Aug 9;170:53-59. doi10.1016/j.thromres.2018.08.004. [Epub ahead of print] PubMed PMID: 30118868.
  152. 153.Mannucci PM, Nobili A, Marchesini E, Oliovecchio E, Cortesi L, Coppola A, Santagostino E, Radossi P, Castaman G, Valdrè L, Santoro C, Tagliaferri A, Ettorre C, Zanon E, Barillari G, Cantori I, Caimi TM, Sottilotta G, Peyvandi F, Iorio A. Rate and appropriateness of polypharmacy in older patients with hemophilia compared with age-matched controls. Haemophilia. 2018 Aug 16. doi: 10.1111/hae.13595. [Epub ahead of print] PubMed PMID: 30112863.
  153. 154.Chai-Adisaksopha C, Skinner MW, Curtis R, Frick N, Nichol MB, Noone D, O'Mahony B, Page D, Stonebraker J, Thabane L, Crowther M, Iorio A. Psychometric properties of the Patient Reported Outcomes, Burdens and Experiences (PROBE) questionnaire. BMJ Open. 2018 Aug 8;8(8):e021900. doi: 10.1136/bmjopen-2018-021900. PubMed PMID: 30093520; PubMed Central PMCID:PMC6089314.
  154. 155.Iorio A, Skinner MW, Clearfield E, Messner D, Pierce GF, Witkop M, et al. Core outcome set for gene therapy in haemophilia: Results of the coreHEM multistakeholder project. Haemophilia [Internet]. 2018 Jul 20;24(4):e167–72.
  155. 156.Croteau SE, Callaghan MU, Davis J, Dunn AL, Guerrera M, Khan O, Neufeld EJ, Raffini LJ, Recht M, Wang M, Iorio A. Focusing in on use of pharmacokinetic profiles in routine hemophilia care. Res Pract Thromb Haemost. 2018 May 27;2(3):607-614. doi: 10.1002/rth2.12118. eCollection 2018 Jul. PubMed PMID 30046766; PubMed Central PMCID: PMC6046597.
  156. 157.Iorio A, Edginton AN, Blanchette V, Blatny J, Boban A, Cnossen M, Collins P, Croteau SE, Fischer K, Hart DP, Ito S, Korth-Bradley J, Lethagen S, Lillicrap D, Makris M, Mathôt R, Morfini M, Neufeld EJ, Spears J. Performing and interpreting individual pharmacokinetic profiles in patients with Hemophilia A or B: Rationale and general considerations. Res Pract Thromb Haemost. 2018 May 20;2(3):535-548. doi: 10.1002/rth2.12106. eCollection 2018 Jul. Review. PubMed PMID: 30046759; PubMed Central PMCID: PMC6046594.
  157. 158.Del Fiol G, Michelson M, Iorio A, Cotoi C, Haynes RB. A Deep Learning Method to Automatically Identify Reports of Scientifically Rigorous Clinical Research from the Biomedical Literature: Comparative Analytic Study. J Med Internet Res. 2018 Jun 25;20(6):e10281. doi: 10.2196/10281. PubMed PMID: 29941415; PubMed Central PMCID: PMC6037944.
  158. 159.Kahale LA, Diab B, Brignardello-Petersen R, Agarwal A, Mustafa RA, Kwong J, Neumann I, Li L, Lopes LC, Briel M, Busse JW, Iorio A, Vandvik PO, Alexander PE, Guyatt G, Akl EA. Systematic reviews do not adequately report or address missing outcome data in their analyses: a methodological survey. J Clin Epidemiol. 2018 Jul;99:14-23. doi: 10.1016/j.jclinepi.2018.02.016. Epub 2018 Mar 2. Review. PubMed PMID: 29505859.
  159. 160.Chai-Adisaksopha C, Iorio A, Crowther MA, de Miguel J, Salgado E, Zdraveska M, Fernández-Capitán C, Nieto JA, Barillari G, Bertoletti L, Monreal M; RIETE investigators. Vitamin K Antagonists after 6 Months of Low-Molecular-Weight Heparin in Cancer Patients with Venous Thromboembolism. Am J Med. 2017 Dec 20. pii: S0002-9343(17)31277-9. doi: 10.1016/j.amjmed.2017.11.042. [Epub ahead of print]. PMID: 29274307.
  160. 161.Marchesini E, Oliovecchio E, Coppola A, Santagostino E, Radossi P, Castaman G, Valdrè L, Santoro C, Tagliaferri A, Ettorre C, Zanon E, Barillari G, Cantori I, Caimi TM, Sottilotta G, Iorio A, Mannucci PM. Comorbidities in persons with haemophilia aged 60 years or more compared with age-matched people from the general population. Haemophilia. 2017 Dec 22. Doi: 10.1111/hae.13379. PMID: 29271531.
  161. 162.Iorio A. Using pharmacokinetics to individualize hemophilia therapy. Hematology. Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):595-604. doi: 10.1182/asheducation-2017.1.595. Review. Pubmed PMID: 29222309.
  162. 163.Neil-Sztramko SE, Farran R, Watson S, Levinson AJ, Lavis JN, Iorio A, Dobbins M. If You Build It, Who Will Come? A Description of User Characteristics and Experiences with the McMaster Optimal Aging Portal. Gerontol Geriatr Med. 2017 Nov 8;3:2333721417737681. doi: 10.1177/2333721417737681. eCollection 2017 Jan-Dec. PMID: 29152540.
  163. 164.Chai-Adisaksopha C, Iorio A, Hillis C, Siegal D, Witt DM, Schulman S, Crowther M. Warfarin resumption following anticoagulant-associated intracranial hemorrhage: A systematic review and meta-analysis. Thromb Res. 2017 Dec;160:97-104. doi: 10.1016/j.thromres.2017.11.001. Epub 2017 Nov 11.PMID: 29136562.
  164. 165.Iorio A, Blanchette V, Blatny J, Collins P, Fischer K, Neufeld E. Estimating and interpreting the pharmacokinetic profiles of individual patients with haemophilia A or B using a population pharmacokinetic approach: communication from the SSC of the ISTH. J Thromb Haemost. 2017 Dec;15(12):2461-2465. Doi: 10.1111/jth.13867. Epub 2017 Nov 9. No abstract available. PMID: 29119666.
  165. 166.Alba AC, Agoritsas T, Walsh M, Hanna S, Iorio A, Devereaux PJ, McGinn T, Guyatt G. Discrimination and Calibration of Clinical Prediction Models: Users' Guides to the Medical Literature. JAMA. 2017 Oct 10;318(14):1377-1384. doi: 10.1001/jama.2017.12126. PMID: 29049590.
  166. 167.McEneny-King A, Chelle P, Henrard S, Hermans C, Iorio A, Edginton AN. Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis. Pharmaceutics. 2017 Oct 17;9(4). pii: E47. doi: 10.3390/pharmaceutics9040047.PMID: 29039750.
  167. 168.Peyvandi F, Makris M, Collins P, Lillicrap D, Pipe SW, Iorio A, Rosendaal FR; Subcommittee on Factor VIII, Factor IX and Rare Coagulation Disorders. Minimal dataset for post-registration surveillance of new drugs in hemophilia: a communication from the SSC of the ISTH. J Thromb Haemost. 2017 Sep;15(9): 1878-1881. Doi: 10.1111/jth.13762. Epub 2017 Aug 2. No abstract available. PMID: 28767195.
  168. 169.Barbara AM, Dobbins M, Brian Haynes R, Iorio A, Lavis JN, Raina P, Levinson AJ. McMaster Optimal Aging Portal: an evidence-based database for geriatrics-focused health professionals. BMC Res Notes. 2017 Jul 11;10(1):271. doi: 10.1186/s13104-017-2595-8.PMID: 28693544.
  169. 170.Hemens BJ, Iorio A. Computer-Aided Systematic Review Screening Comes of Age. Ann Intern Med. 2017 June 13. Doi: 10.7326/M17-1295. [Epub ahead of print] No abstract available. PMID: 28605802.

  170. 171.Lawson W, Uy M, Strike K, Iorio A, Stein N, Koziol L, Chan A.Point of care ultrasound in haemophilia: Building a strong foundation for clinical implementation.Haemophilia. 2017 June 2. Doi: 10.1111/hae.13269. [Epub ahead of print] PMID: 28574191.

  171. 172.Keepanasseril A, Stoffman J, Bouskill V, Carcao M, Iorio A, Jackson S; Association of Haemophilia Centre Directors of Canada (AHCDC). Switching to extended half-life products in Canada – preliminary data. Haemophilia. 2017 May 26. Doi: 10.1111/hae.13245. PMID: 28548284.

  172. 173.Guyatt GH, Ebrahim S, Alonso-Coello P, Johnston BC, Mathioudakis AG, Briel M, Mustafa RA, Sun X, Walter SD, Heels-Ansdell D, Neumann I, Kahale LA, Iorio A, Meerpohl J, Schunemann HJ, Akl EA. GRADE guidelines 17: Assessing the Risk of Bias associated with missing participant outcome data in a body of evidence. J Clin Epidemiol. 2017 May 18. Pii: S0895-4356(16)30811-3. Doi:10.1016/j.jclinepi.2017.05.005. [Epub ahead of print]. PMID: 28529188.

  173. 174.Hultcrantz M, Rind D, Akl EA, Treweek S, Mustafa RA, Iorio A, Alper BS, Meerpohl JJ, Murad MH, Ansari MT, Katikireddi SV, Ostlund P, Tranaeus S, Christensen R, Gartlehner G, Brozek J, Izcovich A, Schunemann H, Guyatt G. The GRADE Working Group clarifies the construct of certainty of evidence. J Clin Epidemiol. 2017 May 18. Pii: S0895-4356(16)30703-X. Doi: 10.1016/j.jclindpi.201705.006. [Epub ahead of print]. PMID: 28529184.

  174. 175.Korte W, Poon MC, Iorio A, Makris M. Thrombosis in Inherited Fibrinogen Disorders. Transfus Med Hemother. 2017 Apr;44(2): 70-76. Doi: 10.1159/000452864. Epub 2017 Mar 14. Review. PMID: 28503122.
  175. 176.Matino D, Chai-Adisaksopha C, Iorio A. Systematic reviews of prognosis studies: a critical appraisal of five core clinical journals. Diagn Progn Res 1, 9 (2017). https://doi.org/10.1186/s41512-017-0008-z.

  176. 177.Busse JW, Craigie S, Juurlink DN, Buckley DN, Wang L, Couban RJ, Agoritsas T, Akl EA, Carrasco-Labra A, Cooper L, Cull C, da Costa BR, Frank JW, Grant G, Iorio A, Persaud N, Stern S, Tugwell P, Vandvik PO, Guyatt G. Guideline for opioid therapy and chronic noncancer pain. CMAJ. 2017 May 8;189(18): E659-E666. Doi: 10.1503/cmaj.170363. PMID: 28483845.

  177. 178.Middeldorp S, Iorio A. Oral contraceptive use is a provoking factor for venous thromboembolism. BMJ. 2017 Apr 27;357:j2073. Doi:10.1136/bmj.j2073. PubMed PMID: 28450404.

  178. 179.Sekercioglu N, Angeliki Veroniki A, Thabane L, Busse JW, Akhtar-Danesh N, Iorio A, Cruz Lopes L, Guyatt GH. Effects of different phosphate lowering strategies in patients with CKD on laboratory outcomes: A systematic review and NMA. PLoS One. 2017 Mar 1;12(3): e0171028.doi:10.1371/journal.pone.0171028. eCollection 2017.

  179. 180.Iorio A, Edginton AN. Exploring some intersections between pharmacokinetics, factor VIII measurement and human morphometrics – impact of recent advances in haemophilia study design on our understanding of optimal haemophilia treatment. Haemophilia. 2017 Mar 21. Doi: 10.1111/hae.13210. [Epub ahead of print] No abstract available. PMID: 28326647.

  180. 181.Iorio A, Iserman E, Blanchette V, Dolan G, Escuriola Ettingshausen C, Hermans C, Negrier C, Oldenburg J, Reininger A, Rodriguez-Merchan C, Spannagl M, Valentino LA, Young G, Steinitz-Trost KN, Gringeri A. Target plasma factor levels for personalized treatment in haemophilia: a Delphi consensus statement.Haemophilia. 2017 May;23(3):e170-e179. Doi:10.1111/hae.13215. Epub 2017 Mar 26. PMID: 28345268.

  181. 182.Iorio A, Fischer K, Blanchette V, Rangarajan S, Young G, Morfini M; Pharmacokinetic (PK) Expert Working Group of the International Prophylaxis Study Group (the IPSG). Tailoring treatment of haemophilia B: accounting for the distribution and clearance of standard and extended half-life FIX concentrates. Thromb Haemost. 2017 Jun 2;117(6): 1023-1030. Doi: 10.1160/TH16-12-0942. Epub 2017 Mar 30. PMID: 28357444 [PubMed-in process].

  182. 183.Iorio A, Fischer K, Makris M. Large scale studies assessing anti-factor VIII antibody development in previously untreated haemophilia A: what has been learned, what to believe and how to learn more. Br J Haematol. 2017 Apr 7. Doi: 10.1111/bjh.14610. [Epub ahead of print] Review.

  183. 184.Iorio A, Barbara AM, Makris M, Fischer K, Castaman G, Catarino C, Gilman E, Kavakli K, Lambert T, Lassila R, Lissitchkov T, Mauser-Bunschoen E, Mingot-Castellano ME, Ozdemir N, Pabinger I, Parra R, Pasi J, Peerlinck, Rauch A, Roussel-Robert V, Serban M, Tagliaferri A, Windyga J, Zanon E. Natural history and clinical characteristics of inhibitors in previously treated haemophilia A patients: a case series. Haemophilia. 2017 Mar;23(2):255-263. Doi: 10.1111/hae.13167. Epub 2017 Feb 15.

  184. 185.Sun J, Zhao Y, Yang R, Guan T, Iorio A; Chinese HERO study group. The demographics, treatment characteristics and quality of life of adult people with haemophilia in China – results from the HERO Study. Haemophilia. 2017 Jan;23(1):89-97.
  185. 186.Van Vulpen L.F, Saccullo G, Iorio A, Makris M. The current state of adverse event reporting in hemophilia. Expert Rev Hematol. 2016 Dec 26:1-8. Doi: 10.1080/17474086.2017.1272410. [Epub ahead of print]. PMID: 28013565.

  186. 187.Iorio A, Keepanasseril A, Foster G, Navarro-Ruan T, McEneny-King A, Edginton AN, Thabane L; WAPPS-Hemo co-investigator network. Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Study Protocol. JMIR Res Protoc 2016 Dec 15;5(4): e239.

  187. 188.Iorio A, Stonebraker JS, Brooker M, Soucie JM; Data and Demographics Committee of the World Federation of Hemophilia. Measuring the quality of haemophilia care across different settings: a set of performance indicators derived from demographics data. Haemophilia. 2016 Dec 8. Doi: 10.111/hae.13127. [Epub ahead of print] PMID: 27928881.

  188. 189.McEneny-King A, Foster G, Iorio A, Edginton AN. Data Analysis Protocol for the Development and Evaluation of Population Pharmacokinetic Models for Incorporation into the Web-Accessible Population Pharmacokinetic Service – Hemophilia (WAPPS-Hemo). JMIR Res Protoc. 2016 Dec 7;5(4): e232.

  189. 190.Fischer K, Iorio A, Hollingsworth R, Makris M; EUHASS collaborators. FVIII inhibitor development according to concentrate: data from the EUHASS registry excluding overlap with other studies. Haemophilia. 2016 Jan;22(1): e36-8. Doi:10.1111/hae.12764. PMID: 26208036.

  190. 191.Yeung CH, Santesso N, Zeraatkar D, Wang A, Pai M, Scholzberg M, Schunemann HJ, Iorio A. Integrated multidisciplinary care for the management of chronic conditions in adults: an overview of reviews and an example of using indirect evidence to inform clinical practice recommendations in the field of rare diseases. Haemophlia. 2016 Jul;22 Suppl 3:41-50. doi: 10.1111/hae.13010.

  191. 192.Lane SJ, Sholapur NS, Yeung CH, Iorio A, Heddle NM, Scholzberg M, Pai M. Understanding stakeholder important outcomes and perceptions of equity, acceptability and feasibility of a care model for haemophilia management in the US: a qualitative study. Hemophilia, 2016 Jul;22 Suppl 3: 23-30. Doi: 10.1111/hae.13009.

  192. 193.Pai M, Santesso N, Yeung CH, Lane SJ, Schunemann HJ, Iorio A. Methodology for the development of the NHF-McMaster Guideline on Care Models for Haemophilia Management. Haemophilia. 2016 Jul;22 Suppl 3:17-22. doi: 10.1111/hae.13007

  193. 194.Pai M, Key NS, Skinner M, Curtis R, Feinstein M, Kessler C, Lane SJ, Makris M, Riker E, Santesso N, Soucie JM, Yeung CH, Iorio A, Schunemann HJ. NHF-McMaster Guideline on Care Models for Haemophilia Management. Haemophilia. 2016 Jul;22 Suppl 3:6-16. doi: 10.1111/hae.13008.

  194. 195.Yeung CH, Santesso N, Pai M, Kessler C, Key NS, Makris M, Navarro-Ruan T, Soucie JM, Schunemann HJ, Iorio A. Care models in the management of haemophilia: a systematic review. Haemophlia. 2016 Jul;22 Suppl 3:31-40. doi: 10.1111/hae.13000.
  195. 196.Schünemann HJ, Ventresca M, Crowther M, Briel M, Zhou Q, Garcia D, Lyman G, Noble S, Macbeth F, Griffiths G, DiNisio M, Iorio A, Beyene J, Mbuagbaw L, Neumann I, Van Es N, Brouwers M, Brozek J, Guyatt G, Levine M, Moll S, Santesso N, Streiff M, Baldeh T, Florez I, Gurunlu Alma O, Solh Z, Ageno W, Marcucci M, Bozas G, Zulian G, Maraveyas A, Lebeau B, Buller H, Evans J, McBane R, Bleker S,Pelzer U, Akl EA; IPDMA heparin use in cancer patients research group. Use of heparins in patients with cancer: individual participant data meta-analysis of randomised trials study protocol. BMJ Open. 2016 Apr 29;6(4): e010569. doi: 10.1136/bmjopen-2015-010569. PubMed PMID: 27130164.
  196. 197.Dolan G, Iorio A, Jokela V, Juusola K, Lassila R. Haemophilia in a real-world setting: the value of clinical experience in data collection. Eur J Haematol. 2016 Feb;96 Suppl 82:3-9. doi: 10.1111/ejh.12715. PubMed PMID: 26809546.
  197. 198.Marcucci M, Skjøth F, Lip GY, Iorio A, Larsen TB. A decisional model to individualize warfarin recommendations: Expected impact on treatment and outcome rates in a real-world population with atrial fibrillation. Int J Cardiol. 2016 Jan 15;203:785-90. doi: 10.1016/j.ijcard.2015.11.035. Epub 2015 Nov 6. PubMed PMID: 26595784.
  198. 199.Alonso-Coello P, Carrasco-Labra A, Brignardello-Petersen R, Neumann I, Akl EA, Vernooij RW, Johnston BC, Sun X, Briel M, Busse JW, Ebrahim S, Granados CE, Iorio A, Irfan A, Martínez García L, Mustafa RA, Ramírez-Morera A, Selva A, Solà I, Sanabria AJ, Tikkinen KA, Vandvik PO, Zazueta OE, Zhang Y, Zhou Q, Schünemann H,Guyatt GH. Systematic reviews experience major limitations in reporting absolute effects. J Clin Epidemiol. 2016 Apr;72:16-26. doi: 10.1016/j.jclinepi.2015.11.002. Epub 2015 Nov 10. PubMed PMID: 26560992.
  199. 200.Fischer K, Iorio A, Hollingsworth R, Makris M; all EUHASS collaborators. FVIII inhibitor development according to concentrate: data from the EUHASS registry excluding overlap with other studies. Haemophilia. 2016 Jan;22(1):e36-8. doi: 10.1111/hae.12764. Epub 2015 Jul 24. PubMed PMID: 26208036.
  200. 201.Romanov V, Marcucci M, Cheng J, Thabane L, Iorio A. Evaluation of safety and effectiveness of factor VIII treatment in haemophilia A patients with low titre inhibitors or a personal history of inhibitor. Patient data meta-analysis of rAFH-PFM post authorization safety studies. Thromb Haemost. 2015 Jul;114(1):5664. doi: 10.1160/TH14100882. Epub 2015 May 28. PMID: 26017627.

  201. 202.Franchi C, Ardoino I, Rossio R, Nobili A, Biganzoli EM, Marengoni A, Marcucci M, Pasina L, Tettamanti M, Corrao S, Mannucci PM; REPOSI Investigators (Iorio A in the REPOSI team author list). Prevalence and risk factors associated with use of QT-prolonging drugs in hospitalized older people. Drugs Aging. 2015 Dec 22. [Epub ahead of print] PubMed PMID: 26693921.

  202. 203.Matino D, Makris M, Dwan K, D’Amico R, Iorio A. Recombinant factor VIIa concentrate versus plasma-derived concentrates for treating acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database Syst Rev. 2015 Dec 16;12:CD004449. [Epub ahead of print] Review. PMID: 26677005.

  203. 204.Marcucci M, Skjøth F, Lip GY, Iorio A. Larsen TB. A decisional model to individualize warfarin recommendations: expected impact on treatment and outcome rates in real-world population with atrial fibrillation. Int J Cardiol. 2015 Nov 6;203:785-790. Doi: 10.1016/j.ijcard.2015.11.035 PMID: 26595784.

  204. 205.Palareti L, Poti S, Cassis F, Emiliani F, Matino D, Iorio A. Shared topics on the experience of people with haemophilia living in the UK and the USA and the influence of individual and contextual variables: results from the HERO qualitative study. Int J Qual Stud Health Well-Being. 2015 Nov 16;10:28915. Doi: 10.3402/qhw.v10.28915. eCollection 2015. PMID: 2657860 [Pubmed – in process].

  205. 206.Alonso-Coello P, Carrasco-Labra A, Brignardello-Petersen R, Neumann I, Akl EA, Vernooij RW, Johnston BC, Sun X, Briel M, Busse JW, Ebrahim S, Granados CE, Iorio A, Irfan A, Martinez Garcia L, Mustafa RA, Ramirez-Morera A, Selva A, Sola I, Sanabria AJ, Tikkinen KA, Vandvik PO, Zazueta OE, Zhou Q, Schunemann H, Guyatt GH. Systematic reviews suffer from major limitations in reporting absolute effects. J Clin Epidemiol. 2015 Nov 8. Pii: S0895-4356(15)00505-3. Doi: 10.1016/j.jclinepi.2015.11.002. [Epub ahead of print] PMID: 26560992.

  206. 207.Carcao MD, Iorio A. Individualizing factor replacement therapy in severe hemophilia. Semin Thromb Hemost. 2015 Nov;41(8):86471. doi: 10.1055/s00351552563. Epub 2015 Aug 13. PMID: 26270111.

  207. 208.Chai-Adisaksopa C, Hillis C, Isayama T, Lim W, Iorio A, Crowther M. Mortality outcomes in patients receiving direct oral anticoagulants: a systematic review and meta-analysis of randomized controlled trials. J Thromb Haemost. 2015 Nov;13(11):201220. doi: 10.1111/jth.13139. Epub 2015 Oct 5. PMID: 26356595.

  208. 209.Bellelli G, Nobili A, Annoni G, Morandi A, Djade CD, Meagher DJ, Maclullich AM, Davis D, Mazzone A, Tettamanti M, Mannucci PM; REPOSI (REgistro POliterapie SIMI) Investigators (Iorio A in the REPOSI team author list). Under-detection of delirium and impact of neurocognitive deficits on in-hospital mortality among acute geriatric and medical wards. Eur J Intern Med. 2015 Nov;26(9):696-704. doi: 10.1016/j.ejim.2015.08.006. Epub 2015 Aug 31. PubMed PMID: 26333532.

  209. 210.Chai-Adisaksopha C, Hillis C, Thabane L, Iorio A. A systematic review of definitions and reporting of bleeding outcome measures in haemophilia. Haemophilia. 2015 Nov;21(6):7315. doi: 10.1111/hae.12750. Epub 2015 Jul 14. PMID: 26179330.

  210. 211.Minuk L, Jackson S, Iorio A, Poon MC, Dilworth E, Brose K, Card R, Rizwan I, ChinYee B, Louzada M. Cardiovascular disease (CVD) in Canadians with haemophilia: Age Related CVD in Haemophilia Epidemiological Research (ARCHER study). Haemophilia. 2015 Nov;21(6):73641. doi: 10.1111/hae.12768. Epub 2015 Jul 29. PMID: 26222883.

  211. 212.Matino D, Gargaro M, Santagostino E, Di Minno MN, Castaman G, Morfini M, Rocino A, Mancuso ME, Di Minno G, Coppola A, Talesa VN, Volpi C, Vacca C, Orabona C, Iannitti R, Mazzucconi MG, Santoro C, Tosti A, Chiappalupi S, Sorci G, Tagariello G, Belvini D, Radossi P, Landolfi R, Fuchs D, Boon L, Pirro M, Marchesini E, Grohmann U, Puccetti P, Iorio A, Fallarino F. IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII. J Clin Invest. 2015 Oct 1;125(10):376681. doi: 10.1172/JCI81859. Epub 2015 Aug 31. PMID: 26426076.

  212. 213.Fischer K, Iorio A, Lassila R, Peyvandi F, Calizzani G, Gatt A, Lambert T, Windyga J, Gilman EA, Makris M; EUHASS Participants. Inhibitor development in nonsevere haemophilia across Europe. Thromb Haemost. 2015 Oct;114(4):6705. doi: 10.1160/TH14121044. Epub 2015 Aug 13. PMID: 26293381.

  213. 214.Akl EA, Carrasco Labra A, Brignardello Petersen R, Neumann I, Johnston BC, Sun X, Briel M, Busse JW, Ebrahim S, Granados CE, Iorio A, Irfan A, Martínez García L, Mustafa RA, Ramírez Morera A, Selva A, Solà I, Sanabria AJ, Tikkinen KA, Vandvik PO, Vernooij RW, Zazueta OE, Zhou Q, Guyatt GH, Alonso Coello P. Reporting, handling and assessing the risk of bias associated with missing participant data in systematic reviews: a methodological survey. BMJ Open. 2015 Sep 30;5(9):e009368. doi: 10.1136/bmjopen2015009368. PMID: 26423858 Free PMC Article.

  214. 215.Santalucia P, Franchi C, Djade CD, Tettamanti M, Pasina L, Corrao S, Salerno F, Marengoni A, Marcucci M, Nobili A, Mannucci PM; REPOSI Investigators (Iorio A in the REPOSI team author list). Gender difference in drug use in hospitalized elderly patients. Eur J Intern Med. 2015 Sep;26(7):483-90. doi: 10.1016/j.ejim.2015.07.006. Epub 2015 Jul 22. PubMed PMID: 26209883.
  215. 216.Strike KL, Iorio A, Jackson S, Lawson W, Scott L, Squire S, Chan AK. Point of care ultrasonography in haemophilia care: recommendations for training and competency evaluation. Haemophilia. 2015 Nov;21(6):82831. doi: 10.1111/hae.12767. Epub 2015 Jul 24. No abstract available. PMID: 26208178.

  216. 217.Rossio R, Franchi C, Ardoino I, Djade CD, Tettamanti M, Pasina L, Salerno F, Marengoni A, Corrao S, Marcucci M, Peyvandi F, Biganzoli EM, Nobili A, Mannucci PM; REPOSI Investigators (Iorio A in the REPOSI team author list). Adherence to antibiotic treatment guidelines and outcomes in the hospitalized elderly with different types of pneumonia. Eur J Intern Med. 2015 Jun;26(5):330-7. doi: 10.1016/j.ejim.2015.04.002. Epub 2015 Apr 18. PubMed PMID: 25898778.

  217. 218.Berntorp E, Iorio A. Reflections on the FranceCoag report on inhibitory antibodies to factor VIII in patients with severe hemophilia A. Blood. 2015 Jun 11;125(24):3816-7. doi: 10.1182/blood-2014-10-608471. No abstract available.PMID: 26069334 [PubMed - in process] Free PMC Article.

  218. 219.Fischer K, Lassila R, Peyvandi F, Calizzani G, Gatt A, Lambert T, Windyga J, Iorio A, Gilman E, Makris M; EUHASS participants. Inhibitor development in haemophilia according to concentrate. Four-year results from the European HAemophilia Safety Surveillance (EUHASS) project. Thromb Haemost. 2015 May;113(5):968-75. doi: 10.1160/TH14-10-0826. Epub 2015 Jan 8.
    PMID: 25567324 [PubMed - in process].

  219. 220.Marcucci M, Mancuso ME, Santagostino E, Kenet G, Elalfy M, Holzhauer S, Bidlingmaier C, Escuriola Ettingshausen C, Iorio A, Nowak-Göttl U. Type and intensity of FVIII exposure on inhibitor development in PUPs with haemophilia A. A patient-level meta-analysis. Thromb Haemost. 2015 May;113(5):958-67. doi: 10.1160/TH14-07-0621. Epub 2015 Jan 29.
    PMID: 25631402 [PubMed - in process].

  220. 221.Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., Sivaramalingam, B., Iserman, E., Mustafa, R. A., Jedraszewski, D., Cotoi, C., & Haynes, R. B. B. Interventions for enhancing medication adherence. Cochrane Database of Systematic Reviews, 2014, 11, CD000011. https://doi.org/10.1002/14651858.CD000011.pub4
  221. 222.Mbuagbaw L, Sivaramalingam B, Navarro T, Hobson N, Keepanasseril A, Wilczynski NJ, Haynes RB; Patient Adherence Review (PAR) Team. (Iorio A listed in the PAR team members). Interventions for enhancing adherence to AntiRetroviral Therapy (ART): a aystematic review of high-quality studies. AIDS Patient Care STDS. 2015 May;29(5):248-66. doi: 10.1089/apc.2014.0308. Epub 2015 Mar 31. Review. PMID: 25825938.

  222. 223.Corrao S, Argano C, Nobili A, Marcucci M, Djade CD, Tettamanti M, Pasina L, Franchi C, Marengoni A, Salerno F, Violi F, Mannucci PM, Perticone F; REPOSI Investigators. Brain and kidney, victims of atrial microembolism in elderly hospitalized patients? Data from the REPOSI study. Eur J Intern Med. 2015 May;26(4):243-9. doi: 10.1016/j.ejim.2015.02.018. Epub 2015 Mar 5. PMID: 25749554.

  223. 224.Marcucci M, Iorio A, Douketis JD, Eichinger S, Tosetto A, Baglin T, Cushman M, Palareti G, Poli D, Tait RC, Kyrle PA. Risk of recurrence after a first unprovoked venous thromboembolism: external validation of the Vienna Prediction Model with pooled individual patient data. Thromb Haemost. 2015 May;13(5):77581. doi: 10.1111/jth.12871. Epub 2015 Mar 12. PMID: 25660555.

  224. 225.Rizwan I, Minuk L, Jackson S, Iorio A. Cardiovascular disease prevalence and relevance in haemophilia: a scoping review. Haemophilia. 2015 May;21(3):e15666. doi: 10.1111/hae.12596. Epub 2014 Nov 24 PMID: 25420604.

  225. 226.Marcucci M, Iorio A, Douketis JD, Eichinger S, Tosetto A, Baglin T, Cushman M, Palareti G, Poli D, Tait RC, Kyrle PA. Risk of recurrence after a first unprovoked venous thromboembolism: external validation of the Vienna prediction model with pooled individual patient data. Thromb Haemost. 2015 May;13(5):77581. doi: 10.1111/jth.12871. Epub 2015 Mar 12. PMID: 25660555.

  226. 227.Marengoni A, Nobili A, Corli O, Djade CD, Bertoni D, Tettamanti M, Pasina L, Corrao S, Salerno F, Marcucci M, Mannucci PM; REPOSI investigators. (Iorio A in the REPOSI team author list). The stigma of low opioid prescription in the hospitalized multimorbid elderly in Italy. InternEmerg Med. 2015 Apr;10(3):305-13. doi: 10.1007/s11739-014-1131-2. Epub 2014 Sep 24. PubMed PMID: 25248643.

  227. 228.Morfini M, Marchesini E, Paladino E, Santoro C, Zanon E, Iorio A. Pharmacokinetics of plasma-derived vs. recombinant FVIII concentrates: a comparative study. Haemophilia. 2015 Mar;21(2):204-9. Doi: 10.1111/hae.12550. Epub 2014 Oct 2. PMID: 25274155.

  228. 229.Iorio A, Spencer FA, Falavigna M, Alba C, Lang E, Burnand B, McGinn T, Hayden J, Williams K, Shea B, Wolff R, Kujpers T, Perel P, Vandvik PO, Glasziou P, Schunemann H, Guyatt G. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ. 2015 Mar 16;350:h870. doi: 10.1136/bmj.h870. No abstract available.
    PMID: 25775931 [PubMed - indexed for MEDLINE].

  229. 230.Jackson SC, Yang M, Minuk L, Sholzberg M, St-Louis J, Iorio A, Card R, Poon MC. Prophylaxis in older Canadian adults with hemophilia A: lessons and more questions. BMC Hematol. 2015 Feb 14;15:4. doi: 10.1186/s12878-015-0022-8. eCollection 2015. PMID: 25692030 [PubMed].

  230. 231.McCarthy A, Moore A, Redhead L, McLaughlin P, Iorio A, Chowdary P. Development of haemophilic arthropathy of the ankle: results of a Delphi consensus survey on potential contributory factors. Haemophilia. 2015 Jan;21(1):11623. doi: 10.1111/hae.12500. Epub 2014 Nov 24. PMID: 25421726.

  231. 232.Nugent D, Kalnins W, Querol F, Gregory M, Pilgaard T, Cooper DL, Iorio A. Haemophilia Experiences, Results and Opportunities (HERO) study: treatment-related characteristics of the population. Haemophilia. 2015 Jan;21(1): e26-38. doi: 10.1111/hae.12545. Epub 2014 Nov 7. PMID: 25377442.

  232. 233.Moja L, Kwag KH, Lytras T, Bertizzolo L, Brandt L, Pecoraro V, Rigon G, Vaona A, Ruggiero F, Mangia M, Iorio A, Kunnamo I, Bonovas S. Effectiveness of computerized decision support systems linked to electronic health records: a systematic review and meta-analysis. Am J Public Health. 2014 Dec;104(12):e12-22. doi: 10.2105/AJPH.2014.302164. Epub 2014 Oct 16. Review.
    PMID: 25322302 [PubMed - indexed for MEDLINE].

  233. 234.Akl EA, Kahale LA, Agarwal A, Al-Matari N, Ebrahim S, Alexander PE, Briel M, Brignardello-Petersen R, Busse JW, Diab B, Iorio A, Kwong J, Li L, Lopes LC, Mustafa R, Neumann I, Tikkinen KA, Vandvik PO, Zhang Y, Alonso-Coello P, Guyatt G. Impact of missing participant data for dichotomous outcomes on pooled effect estimates in systematic reviews: a protocol for a methodological study. Syst Rev. 2014 Nov 26;3:137. doi: 10.1186/2046-4053-3-137. PMID: 25423894 [PubMed - in process] Free PMC Article.

  234. 235.Marcucci M, Lip GY, Nieuwlaat R, Pisters R, Crijns HJ, Iorio A. Stroke and bleeding risk co-distribution in real-world patients with atrial fibrillation: the Euro Heart Survey. Am J Med. 2014 Oct;127(10):979-986.e2. doi: 10.1016/j.amjmed.2014.05.003. Epub 2014 May 13. PMID: 24838192 [PubMed - indexed for MEDLINE].

  235. 236.Agoritsas T, Iserman E, Hobson N, Cohen N, Cohen A, Roshanov PS, Perez M, Cotoi C, Parrish R, Pullenayegum E, Wilczynski NL, Iorio A, Haynes RB. Increasing the quantity and quality of searching for current best evidence to answer clinical questions: protocol and intervention design of the MacPLUS FS Factorial Randomized Controlled Trials. Implement Sci. 2014 Sep 20;9:125. doi: 10.1186/s13012-014-0125-9.
    PMID: 25239537 [PubMed - indexed for MEDLINE].

  236. 237.Matino D, Iorio A. Answering relevant research questions via careful observation of clinical practice: a fresh look at the old way forward. Haemophilia. 2014 Sep;20(5):604-6. doi: 10.1111/hae.12511. Epub 2014 Aug 25. PubMed PMID: 25154445.

  237. 238.Cassis FR, Buzzi A, Forsyth A, Gregory M, Nugent D, Garrido C, Pilgaard T, Cooper DL, Iorio A. Haemophilia Experiences, Results and Opportunities (HERO) Study: influence of haemophilia on interpersonal relationships as reported by adults with haemophilia and parents of children with haemophilia. Haemophilia. 2014 Jul;20(4):e287-95. doi: 10.1111/hae.12454. Epub 2014 May 7. PubMed PMID: 24800872.

  238. 239.Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P. Aryl hydrocarbon receptor control of a disease tolerance defense pathway. Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323. PMID: 24930766 [PubMed - indexed for MEDLINE].

  239. 240.Athale AH, Marcucci M, Iorio A. Immune tolerance induction for treating inhibitors in people with congenital haemophilia A or B. Cochrane Database Syst Rev. 2014 Apr 24;4:CD010561. doi: 10.1002/14651858.CD010561.pub2. Review. PMID: 24763974 [PubMed - in process].

  240. 241.Athale, A., Giguere, A., Barbara, A., Krassova, S., & Iorio, A. Developing a two-sided intervention to facilitate shared decision-making in haemophilia: decision boxes for clinicians and patient decision aids for patients. Haemophilia, 2014; 20(6), 800–806. https://doi.org/10.1111/hae.12495
  241. 242.Matino D, Teitel J, Page D, Keepanassseril A, Iorio A, Walker I. The haemophilia certification system in Canada. Blood Transfus. 2014 Apr;12 Suppl 3:e531-41. doi: 10.2450/2014.0032-14s. Review. No abstract available.PMID: 24922284 [PubMed - indexed for MEDLINE].

  242. 243.Iorio A, Douketis JD. Ruling out DVT using the Wells rule and a D-dimer test. BMJ. 2014 Mar 10;348:g1637. doi: 10.1136/bmj.g1637. No abstract available. PMID: 24615174 [PubMed - indexed for MEDLINE].

  243. 244.Donadini MP, Ageno W, Antonucci E, Cosmi B, Kovacs MJ, Le Gal G, Ockelford P, Poli D, Prandoni P, Rodger M, Saccullo G, Siragusa S, Young L, Bonzini M, Caprioli M, Dentali F, Iorio A, Douketis JD. Prognostic significance of residual venous obstruction in patients with treated unprovoked deep vein thrombosis: a patient-level meta-analysis. Thromb Haemost. 2014 Jan;111(1):172-9. doi: 10.1160/TH13-04-0336. Epub 2013 Oct 24. PMID: 24154729 [PubMed - indexed for MEDLINE].

  244. 245.Donadini MP, Ageno W, Antonucci E, Cosmi B, Kovacs MJ, Le Gal G, Ockelford P, Poli D, Prandoni P, Rodger M, Saccullo G, Siragusa S, Young L, Bonzini M, Caprioli M, Dentali F, Iorio A, Douketis JD. Prognostic significance of residual venous obstruction in patients with treated unprovoked deep vein thrombosis: a patient-level meta-analysis. Throm Haemost. 2014 Jan;111(1):172-9. doi: 10.1160/TH13-04-0336. Epub 2013 Oct 24. PubMed PMID: 24154729.

  245. 246.Santagostino E, Lentz SR, Busk AK, Regnault A, Iorio A. Assessment of the impact of treatment on quality of life of patients with haemophilia A at different ages: insights from two clinical trials on turoctocog alfa. Haemophilia. 2014 Jul;20(4):527-34. doi: 10.1111/hae.12371. Epub 2014 Jan 29. PubMed PMID: 24471912.

  246. 247.Marcucci M, Mancuso ME, Santagostino E, Kenet G, Elalfy M, Holzhauer S, Bidlingmaier C, Escuriola Ettingshausen C, Iorio A and Nowak-Gottl U. Effect of type and intensity of FVIII exposure on inhibitors development in hemophilia A: first results of an individual patient data meta-analytic project. Journal of Thrombosis and Haemostasis 2013, 11 (Suppl 2) Jul ISSN 1538–7933. AS 22.2.

  247. 248.Matino D, Lillicrap D, Astermark J, Dolan G, Kessler C, Lambert T, Makris M, O’Donnell J, Pipe S, Santagostino E, Saint-Remy JM, Schramm W, Iorio A. Switching clotting factor concentrates: considerations in estimating the risk of immunogenicity. Haemophilia. 2014 Mar;20(2):200-6. doi: 10.1111/hae.12283. Epub 2013 Oct 29. PubMed PMID: 24533949.

  248. 249.Marcucci M, Iorio A, Nobili A, Tettamanti M, Pasina L, Djade CD, Marengoni A, Salerno F, Corrao S, Mannucci PM; REPOSI (Registro Politerapie Societa Ialiana di Medicina Interna) Investigators. Prophylaxis of venous thromboembolism in elderly patients with multimorbidity. Intern Emerg Med. 2013;Sep;8(6):509-20. doi: 10.1007/s1173901309448. Epub 2013†May 8. PMID: 23653407.

  249. 250.Forsyth AL, Gregory M, Nugent D, Garrido C, Pilgaard T, Cooper DL, Iorio A. Haemophilia Experiences, Results and Opportunities (HERO) Study: survey methodology and population demographics. Haemophilia. 2014 Jan;20(1):44-51. doi:10.1111/hae.12239. Epub 2013 Aug 1. PubMed PMID: 23902228.

  250. 251.Marcucci M, Iorio A, Douketis J. Management of patients with unprovoked venous thromboembolism: an evidence-based and practical approach. Curr Treat Options Cardiovasc Med. 2013 Apr;15 (2): 224-39. Doi: 10.1007/s11936-012-0225-2. PubMed PMID: 23344704; PubMed Central PMID: PMC3608888.

  251. 252.Iorio A, Skinner MW, Makris M. Factor VIII products and inhibitors in severe hemophilia A. N. Engl J Med. 2013 Apr 11;368(15): 1456. Doi: 10.1056/NEJMc1301995#SA1. PubMed PMID: 2374132.

  252. 253.Santagostino E, Messina M, Tagliaferri A, Iorio A, Morfini M. Haemophilia at various states of life: design of new therapeutic strategies through an interactive course – the Kogeniale project. Blood Transfus. 2013 Apr;11(2): 272-80. Doi: 10.2450/2012.0158-12. Epub 2013 Jan 23. PubMed PMID: 23399360; PubMed Central PMCID: PMC3626480.

  253. 254.Marcucci M, Smith CT, Douketis JD, Tosetto A, Baglin T, Cushman M, Eichinger S, Palareti G, Poli D, Tait RC, Iorio A. Patient-level compared with study-level meta-analyses demonstrate consistency of D-dimer as predictor of venous thromboembolic recurrences. J Clin Epidemiol. 2013 Apr;66(4) : 415-25. Doi: 10.1016/j.jclinepi.2012.08.007. Epub 2013 Feb 8. PubMed PMID: 23395515.

  254. 255.Marengoni A, Nobili A, Pirali C, Tettamanti M, Pasina L, Salerno F, Corrao S, Iorio A, Marcucci M, Franchi C, Mannucci PM. Comparison of disease clusters in two elderly populations hospitalized in 2008 and 2010. Gerontology. 2013;59(4):307-15. doi: 10.1159/000346353. Epub 2013 Jan 25. PMID: 23364029.

  255. 256.Cassis FR, Querol F, Forsyth A, Iorio A; on behalf of the HERO International Advisory Board. Psychosocial aspects of haemophilia: a systematic review of methodologies and findings. Haemophilia. 2012 May;18(3):e101-e114. doi: 10.1111/j.1365-2516.2011.02683.x. Epub 2011 Nov 8. PubMed PMID: 22059839.

  256. 257.Knoebl P, Marco P, Baudo F, Collins P, Huth-Kühne A, Nemes L, Pellegrini F,Tengborn L, Lévesque H; EACH2 Registry Contributors (Iorio A listed). Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost. 2012 Apr;10(4):622-31. doi:10.1111/j.1538-7836.2012.04654.x. PubMed PMID: 22321904.

  257. 258.Zanon E, Iorio A, Rocino A, Artoni A, Santoro R, Tagliaferri A, Coppola A, Castaman G, Mannucci PM; Italian Association of Hemophilia Centers, Barillari G, Dragani A, Gamba G, Giuffrida A, Lapecorella M, Mancuso G, Lucia L, Mazzucconi MG, Messina M, Musso R, De Martis F, Rossetti G, Schinco P, Spiezia L, Valdrè L. Intracranial haemorrhage in the Italian population of haemophilia patients with and without inhibitors. Haemophilia. 2012 Jan;18(1):39-45. doi: 10.1111/j.1365-2516.2011.02611.x. Epub 2011 Jul 14. PubMed PMID: 21752159.

  258. 259.Siboni SM, Zanon E, Sottilotta G, Consonni D, Castaman G, Mikovic D, Biondo F, Tagliaferri A, Iorio A, Mannucci PM, Peyvandi F. Central nervous system bleeding in patients with rare bleeding disorders. Haemophilia. 2012 Jan;18(1):34-8. doi: 10.1111/j.1365-2516.2011.02545.x. Epub 2011 May 4. PubMed PMID: 21539694.
  259. 260.Tosetto A, Iorio A, Marcucci M, Baglin T, Cushman M, Eichinger S, Palareti G, Poli D, Tait RC, Douketis J. Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH). J Thromb Haemost 2012;10:1019-5.

  260. 261.Marengoni A, Corrao S, Nobili A, Tettamanti M, Pasina L, Salerno F, Iorio A, Marcucci M, Bonometti F, Mannucci PM; on behalf of SIMI Investigators (SIMI denotes the Italian Society of Internal Medicine. The participating units and co-authors are listed in the Appendix). In-hospital death according to dementia diagnosis in acutely ill elderly patients: the REPOSI study. Int J Geriatr Psychiatry. 2011 Sep;26(9):930-6. doi: 10.1002/gps.2627. Epub 2010 Nov 9. PubMed PMID: 21061413.

  261. 262.Marcucci M, Nobili A, Iorio A. More about optimal choices in cardioembolism prevention. Eur J Intern Med 2011;22:e-19.

  262. 263.Iorio A, Marcucci M, Makris M. Concentrate-related inhibitor risk: is a difference always real? J Thromb Haemost. 2011 Nov;9(11):2176-9. doi: 10.1111/j.1538-7836.2011.04480.x. PubMed PMID: 21854537.

  263. 264.Federici AB, Bucciarelli P, Castaman G, Baronciani L, Canciani MT, Mazzucconi MG, Morfini M, Rocino A, Schiavoni M, Oliovecchio E, Iorio A, Mannucci PM. Management of inherited von Willebrand disease in Italy: results from the retrospective study on 1234 patients. Semin Thromb Hemost. 2011 Jul;37(5):511-21. Epub 2011 Nov 18. PubMed PMID: 22102194.

  264. 265.Siragusa S, Malato A, Saccullo G, Iorio A, Di Ianni M, Caracciolo C, Coco LL, Raso S, Santoro M, Guarneri FP, Tuttolomondo A, Pinto A, Pepe I, Casuccio A, Abbadessa V, Licata G, Battista Rini G, Mariani G, Di Fede G. Residual vein thrombosis for assessing duration of anticoagulation after unprovoked deep vein thrombosis of the lower limbs: the extended DACUS study. Am J Hematol. 2011 Nov;86(11):914-7. doi: 10.1002/ajh.22156. Epub 2011 Sep 22. PubMed PMID: 21953853.

  265. 266.Kenet G, Aronis S, Berkun Y, Bonduel M, Chan A, Goldenberg NA, Holzhauer S, Iorio A, Journeycake J, Junker R, Male C, Manco-Johnson M, Massicotte P, Mesters R, Monagle P, van Ommen H, Rafini L, Simioni P, Young G, Nowak-Göttl U. Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: a systematic review and meta-analysis. Semin Thromb Hemost. 2011 Oct;37(7):802-9. Epub 2011 Dec 20. Review. PubMed PMID: 22187403.

  266. 267.Nobili A, Marengoni A, Tettamanti M, Salerno F, Pasina L, Franchi C, Iorio A, Marcucci M, Corrao S, Licata G, Mannucci PM. Association between clusters of diseases and polypharmacy in hospitalized elderly patients: results from the REPOSI study. Eur J Intern Med. 2011 Dec;22(6):597-602. Epub 2011 Sep 29. PubMed PMID: 22075287.

  267. 268.Iorio A, Marchesini E, Marcucci M, Stobart K, Chan AK. Clotting factor concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B. Cochrane Database Syst Rev. 2011 Sep 7;(9):CD003429. Review. PubMed PMID: 21901684.

  268. 269.Marengoni A, Corrao S, Nobili A, Tettamanti M, Pasina L, Salerno F, Iorio A, Marcucci M, Bonometti F, Mannucci PM; SIMI Investigators. In-hospital death according to dementia diagnosis in acutely ill elderly patients: the REPOSI study. Int J Geriatr Psychiatry. 2011 Sep;26(9):930-6. doi: 10.1002/gps.2627. Epub 2010 Nov 9. PubMed PMID: 21845595.

  269. 270.Giampaolo A, Abbonizio F, Puopolo M, Arcieri R, Mannucci PM; Italian Association of Haemophilia Centres, Hassan HJ, Accorsi A, Ettorre PC, Schiavoni M, Palareti G, Rodorigo G, Valdré L, Amaddii G, Billio A, Notarangelo L, Iannacaro P, Muleo P, Biasioli C, Rossi V, Alatri A, Testa S, Vincenzi D, Scapoli G, Morfini M, Molinari AC, Lapecorella M, Mariani G, Baudo F, Caimi MT, Federici AB, Gringeri A, Mannucci PM, Santagostino E, Marietta M, Coppola A, Di Minno G, Perricone C, Schiavulli. Consumption of clotting factors in severe haemophilia patients undergoing prophylaxis and on-demand treatment in Italy. Transfus Med. 2011 Aug;21(4):280-4. doi: 10.1111/j.1365-3148.2011.01074.x. Epub 2011 Mar 30. PubMed PMID: 21733006.

  270. 271.Douketis JD, Iorio A. The association between venous thromboembolism and physical inactivity in everyday life. BMJ. 2011 Jul 4;343:d3865. doi: 10.1136/bmj.d3865. PubMed PMID: 21727168.

  271. 272.Marchesini, E, Prisco, D, Iorio, A. Recombinant Factor VIIa concentrate versus plasma-derived concentrates for the treatment of acute bleeding episodes in persons with haemophilia and inhibitors. European Oncology and Haematology. 2011, 7:Summer(2)140-142.

  272. 273.Iorio A. ACP Journal Club. The Wells rule and a primary care rule were useful for ruling out deep venous thrombosis in primary care. Ann Intern Med. 2011 Jun 21;154(12):JC6-13. PubMed PMID: 21690591.

  273. 274.Nobili A, Licata G, Salerno F, Pasina L, Tettamanti M, Franchi C, De Vittorio L, Marengoni A, Corrao S, Iorio A, Marcucci M, Mannucci PM; SIMI Investigators. Polypharmacy, length of hospital stay, and in-hospital mortality among elderly patients in internal medicine wards. The REPOSI study. Eur J Clin Pharmacol. 2011 May;67(5):507-19. Epub 2011 Jan 11. PubMed PMID: 21221958.

  274. 275.Pasina L, Nobili A, Tettamanti M, Salerno F, Corrao S, Marengoni A, Iorio A, Marcucci M, Mannucci PM; REPOSI Investigators. Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly. Eur J Intern Med. 2011 Apr;22(2):205-10. Epub 2010 Dec 21. PubMed PMID: 21402255.

  275. 276.Douketis J, Tosetto A, Marcucci M, Bagli T, Cushman M, Kryle P, Cosmi B, Poli D, Tait RC, Iorio A. Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysis. BMJ. 2011 Feb 24;342:d813. Review. PubMed PMID: 21349898; PubMed Central PMCID: PMC3044449.

  276. 277.Rocca A, Pizzinelli S, Oliovecchio E, Santagostino E, Rocino A, Iorio A. An Italian ad hoc study group. Replacement therapy with recombinant factor IX. A multicentre evaluation of current dosing practices in Italy. Blood Transfus. 2011 Jan 9(1):60-9.

  277. 278.Malato A, Saccullo G, Iorio A, Ageno W, Siragusa S. Residual vein thrombosis and D-dimer for optimizing duration of anticoagulation in idiopathic deep vein thrombosis. Curr Pharm Des. 2010;16(31):3483-6. Review. PubMed PMID: 20858182.

  278. 279.Marcucci M, Iorio A, Nobili A, Tettamanti M, Pasina L, Marengoni A, Salerno F,Corrao S, Mannucci PM; REPOSI Investigators. Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards. Eur J Intern Med. 2010 Dec;21(6):516-23.

  279. 280.Baglin T, Douketis J, Tosetto A, Marcucci M, Cushman M, Kyrle P, Palareti G, Poli D, Tait RC, Iorio A. Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient-level meta-analysis. J Thromb Haemost. 2010 Nov;8(11):2436-42. doi:10.1111/j.1538-7836.2010.04022.x. PubMed PMID: 20723032.

  280. 281.Kearon C, Iorio A, Palareti G; Subcommittee on Control of Anticoagulation of the SSC of the ISTH. Risk of recurrent venous thromboembolism after stopping treatment in cohort studies: recommendation for acceptable rates and standardized reporting. J Thromb Haemost. 2010 Oct;8(10):2313-5. doi:10.1111/j.1538-7836.2010.03991.x. PubMed PMID: 20738761.

  281. 282.Iorio A, Kearon C, Filippucci E, Marcucci M, Macura A, Pengo V, Siragusa S, Palareti G. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med. 2010 Oct 25;170(19):1710-6. Review. PubMed PMID: 20975016.

  282. 283.Douketis J, Tosetto A, Marcucci M, Baglin T, Cushman M, Eichinger S, Palareti G, Poli D, Tait RC, Iorio A. Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism. Ann Intern Med. 2010 Oct 19;153(8):523-31. Review. PubMed PMID: 20956709.

  283. 284.Iorio A. ACP Journal Club. A 9-factor score predicted 2-year risk for bleeding in outpatients with, or at high risk for, atherothrombosis. Ann Intern Med. 2010 Oct 19;153(8):JC4-13. PubMed PMID: 20956697.

  284. 285.Iorio A, Matino D, D’Amico R, Makris M. Recombinant Factor VIIa concentrate versus plasma derived concentrates for the treatment of acute bleeding episodes in people with haemophilia and inhibitors. Cochrane Database Syst Rev. 2010 Aug 4;(8):CD004449. Review. PubMed PMID: 20687076.

  285. 286.Marengoni A, Bonometti F, Nobili A, Tettamanti M, Salerno F, Corrao S, Iorio A, Marcucci M, Mannucci PM; Italian Society of Internal Medicine (SIMI) Investigators. In-hospital death and adverse clinical events in elderly patients according to disease clustering: the REPOSI study. Rejuvenation Res. 2010 Aug;13(4):469-77. PubMed PMID: 20586646.

  286. 287.Giuliano V, Bassotti G, Mourvaki E, Castellani D, Filippucci E, Sabatino G, Gizzi S, Palmerini F, Galli F, Morelli O, Baldoni M, Morelli A, Iorio A. Small intestinal bacterial overgrowth and warfarin dose requirement variability. Thromb Res. 2010 Jul;126(1):12-7. Epub 2010 Jan 3. PubMed PMID: 20051286.

  287. 288.Iorio A, Halimeh S, Holzhauer S, Goldenberg N, Marchesini E, Marcucci M, Young G, Bidlingmaier C, Brandao LR, Ettingshausen CE, Gringeri A, Kenet G, Knöfler R, Kreuz W, Kurnik K, Manner D, Santagostino E, Mannucci PM, Nowak-Göttl U. Rate of inhibitor development in previously untreated hemophilia A patients treated with plasma-derived or recombinant factor VIII concentrates: a systematic review. J Thromb Haemost. 2010 Jun;8(6):1256-65. Epub 2010 Mar 17. Review. PubMed PMID: 20345722.

  288. 289.Tagliaferri A, Rivolta GF, Iorio A, Oliovecchio E, Mancuso ME, Morfini M, Rocino A, Mazzucconi MG, Franchini M; Italian Association of Hemophilia Centers, Ciavarella N, Scaraggi A, Valdrè L, Tagariello G, Radossi P, Muleo G, Iannaccaro PG, Biasoli C, Vincenzi D, Serino ML, Linari S, Molinari C, Boeri E, La Pecorella M, Carloni MT, Santagostino E, Di Minno G, Coppola A, Rocino A, Zanon E, SpieziaL, Di Perna C, Marchesini M, Marcucci M, Dragani A, Macchi S, Albertini P, D’Incà M. Mortality and causes of death in Italian persons with haemophilia, 1990-2007. Haemophilia. 2010 May 16(3):437-46. Epub 2010 Feb 9. PubMed PMID: 20148978.

  289. 290.Macura A, Abraha I, Kirkham J, Gensini GF, Moja L, Iorio A. Selective outcome reporting: telling and detecting true lies. The state of the science. Intern Emerg Med. 2010 Apr;5(2):151-5. Epub 2010 Mar 19. PubMed PMID: 20300879.

  290. 291.Iorio A, Basileo M, Marcucci M, Guercini F, Camilloni B, Paccamiccio E, Vecchioli M, Iorio AM. Influenza vaccination and vitamin K antagonist treatment: a placebo-controlled, randomized, double-blind crossover study. Arch Intern Med. 2010 Apr 12;170(7):609-16. PubMed PMID: 20386004.

  291. 292.Kenet G, Lütkhoff LK, Albisetti M, Bernard T, Bonduel M, Brandao L, Chabrier S, Chan A, deVeber G, Fiedler B, Fullerton HJ, Goldenberg NA, Grabowski E, Günther G, Heller C, Holzhauer S, Iorio A, Journeycake J, Junker R, Kirkham FJ, Kurnik K, Lynch JK, Male C, Manco-Johnson M, Mesters R, Monagle P, van Ommen CH, Raffini L, Rostásy K, Simioni P, Sträter RD, Young G, Nowak-Göttl U. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies. Circulation. 2010 Apr 27;121(16):1838-47. Epub 2010 Apr 12. Review. PubMed PMID: 20385928.

  292. 293.Cosmi B, Legnani C, Iorio A, Pengo V, Ghirarduzzi A, Testa S, Poli D, Tripodi A, Palareti G; PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics). Residual venous obstruction, alone and in combination with D-dimer, as a risk factor for recurrence after anticoagulation withdrawal following a first idiopathic deep vein thrombosis in the prolong study. Eur J Vasc Endovasc Surg. 2010 Mar;39(3):356-65. Epub 2010 Jan 19. PubMed PMID: 20034816.

  293. 294.Iorio A, Fabbriciani G, Marcucci M, Brozzetti M, Filipponi P. Bone mineral density in haemophilia patients. A meta-analysis. Thromb Haemost. 2010 Mar;103(3):596-603. Epub 2010 Jan 13. PubMed PMID: 20076854.

  294. 295.Iorio A, Marchesini E, Awad T, Gluud LL. Antiviral treatment for chronic hepatitis C in patients with human immunodeficiency virus. Cochrane Database Syst Rev. 2010 Jan 20;(1):CD004888. Review. PubMed PMID: 20091566.

  295. 296.G. Tagariello, A. Iorio, P.M. Mannucci. Author Response: Insufficient evidence to suggest less stringent therapy in haemophilia B? Blood 2009;114(23):4907.

  296. 297.A. Iorio. International clinical trials are the best way to improve global haemophilia care? No. Haemophilia 2009; 15(Suppl1),13.

  297. 298.Siboni SM, Mannucci PM, Gringeri A, Franchini M, Tagliaferri, Ferretti M, Tradati FC, Santagostino E and Von Mackensen S for the Italian Association of Hemophilia Centres (AICE). Health status and quality of life of elderly persons with severe hemophilia born before the advent of modern replacement therapy. Journal of Thrombosis and Haemostasis. 7:780-786. DOI: 10.1111/j.1538-7836.2009.03318.x (A. Iorio in the Medline published coauthors list) (IF = 5,947).

  298. 299.A. Coppola, M. Margaglione, E. Santagostino, A. Rocino, E. Grandone, P.M. Mannucci, G. Di Minno for the AICE PROFIT Study Group. Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction (ITI) of hemophilia A patients with high-responding inhibitors. J Thromb Haemost. 2009 Nov;7(11):1809-15. Epub 2009 Sep 9.

  299. 300.Iorio A, Ageno W, Cosmi B, Imberti D, Lussana F, Siragusa S, Tormene D, Tosetto A, Cattaneo M. Objectives and methodology: guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res. 2009 Nov;124(5):e1-5. Epub 2009 Jun 26. PubMed PMID: 19559468.

  300. 301.Gluud LL, Marchesini E, Iorio A. Peginterferon plus ribavirin for chronic hepatitis C in patients with human immunodeficiency virus. Am J Gastroenterol. 2009 Sep;104(9):2335-41; quiz 2342. Epub 2009 Jun 9. Review. PubMed PMID:19513022.

  301. 302.Ageno W, Garcia D, Aguilar MI, Douketis J, Finazzi G, Imberti D, Iorio A, Key NS, Lim W, Marietta M, Prisco D, Sarode R, Testa S, Tosetto A, Crowther M. Prevention and treatment of bleeding complications in patients receiving vitamin K antagonists, part 2: Treatment. Am J Hematol. 2009 Sep;84(9):584-8. Review. PubMed PMID: 19610020.

  302. 303.Iorio A, Marcucci M. Clinical trials and haemophilia: does the Bayesian approach make the ideal and desirable good friends? Haemophilia. 2009 Jul;15(4):900-3. Epub 2009 Apr 7. Review. PubMed PMID: 19473413.

  303. 304.Tagariello G, Iorio A, Santagostino E, Morfini M, Bisson R, Innocenti M, Mancuso ME, Mazzucconi MG, Pasta GL, Radossi P, Rodorigo G, Santoro C, Sartori R, Scaraggi A, Solimeno LP, Mannucci PM; Italian Association Hemophilia Centre (AICE). Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the 2 coagulation disorders. Blood. 2009 Jul 23;114(4):779-84. Epub 2009 Apr 8. Review. PubMed PMID: 19357395.

  304. 305.Santoro C, Iorio A, Ferrante F, Pallotta A, Pignoloni P, Biondo F, Agnelli G, Mazzucconi MG. Performance of recalibrated ReFacto laboratory standard in the measurement of FVIII plasma concentration via the chromogenic and one-stage assays after infusion of recalibrated ReFacto (B-domain deleted recombinant factor VIII). Haemophilia. 2009 May;15(3):779-87. Epub 2009 Feb 27. PubMed PMID:19298379.

  305. 306.Iorio A, Oliovecchio E, Morfini M, Mannucci PM; Association of Italian Hemophilia Centres Directors. Italian Registry of Haemophilia and Allied Disorders. Objectives, methodology and data analysis. Haemophilia. 2008 May;14(3):444-53. Epub 2008 Mar 18. Erratum in: Haemophilia. 2009 Mar;15(2):637. PubMed PMID: 18355268.

  306. 307.Iorio A, Barnes C, Vedovati MC, Favaloro EJ. Thrombophilia and cerebral vein thrombosis. Front Neurol Neurosci. 2008;23:55-76. Review. PubMed PMID: 18004053.

  307. 308.Iorio A. Iatrogenic causes of an ICH: OAT therapy. Eur J Anaesthesiol Suppl. 2008;42:8-11. Review. PubMed PMID: 18289410.

  308. 309.Musso R, Santagostino E, Faradji A, Iorio A, van der Meer J, Ingerslev J,Lambert T, Maas-Enriquez M, Gorina E; for the KOGENATE® Bayer European PMS Study Group. Safety and efficacy of sucrose-formulated full-length recombinant factor VIII: Experience in the standard clinical setting. Thromb Haemost. 2008; 99(1): 52-58.

  309. 310.Verso M, Iorio A. Review: Perioperative LMW heparin does not reduce mortality after surgery more than unfractionated heparin in patients with cancer. ACP J Club. 2008 Dec 16;149(6):11. PubMed PMID: 19071877.

  310. 311.Iorio A, Basileo M, Marchesini E, Palazzesi GP, Materazzi M, Marchesi M, Esposito A, Pellegrini L, Germani A, Rocchetti L, Silvani CM. Audit of the clinical use of fresh-frozen plasma in Umbria: study design and results of the pilot phase. Blood Transfus. 2008 Oct;6(4):211-9. PubMed PMID: 19112736; PubMed Central PMCID: PMC2626902.

  311. 312.Iorio A, Moja L, Liberati A, Gensini GF, Gusinu R, Conti AA. Selecting references that match constructs: the difficult job of citing the parachute hyperbole. Intern Emerg Med. 2008 Jun;3(2):151-4. PubMed PMID: 18437290.

  312. 313.Iorio A, Basileo M, Marchesini E, Materazzi M, Marchesi M, Esposito A, Palazzesi GP, Pellegrini L, Pasqua BL, Rocchetti L, Silvani CM. The good use of plasma. A critical analysis of five international guidelines. Blood Transfus. 2008 Jan;6(1):18-24. PubMed PMID: 18661920; PubMed Central PMCID: PMC2626858.

  313. 314.Musso R, Santagostino E, Faradji A, Iorio A, van der Meer J, Ingerslev J, Lambert T, Maas-Enriquez M, Gorina E; KOGENATE Bayer European PMS Study Group. Safety and efficacy of sucrose-formulated full-length recombinant factor VIII: experience in the standard clinical setting. Thromb Haemost. 2008 Jan;99(1):52-8. PubMed PMID: 18217134.

  314. 315.Palareti G, Cosmi B, Iorio A. D-Dimer and duration of anticoagulation. New England Journal of Medicine, 2007; 356 (4): 421-3.

  315. 316.Iorio A, Vedovati MC, Filippucci E, Agnelli G. Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence. Intern Emerg Med. 2007 Oct;2(3):202-6. PubMed PMID: 17909704.

  316. 317.Iorio A, Federici MO, Mourvaki E, Ferolla P, Piroddi M, Stabile A, Timi A, Celleno R, Benedetti MM. Impaired endothelial antithrombotic activity following short-term interruption of continuous subcutaneous insulin infusion in type 1 diabetic patients. Thromb Haemost. 2007 Sep;98(3):635-41. PubMed PMID: 17849053.

  317. 318.Baldi G, Altomonte F, Altomonte M, Ghirarduzzi A, Brusasco C, Parodi RC, Ricciardi A, Remollino V, Spisni V, Saporito A, Caiazza A, Musso G, Cervellin G, Lamberti S, Buzzalino M, De Giorgi F, Del Prato C, Golinelli MP, Gai V, Monsù R, Gioffre’ M, Giovanardi D, Cattaneo S, Frumento F, Caporrella A, Re G, De Iaco F,Bologna G, Nocenti F, Lorenzi C, Zoratti R, Sciolla A, Tiscione V, Pastorello M,
    Vandelli A, Villa A, Zanna M, De Palma A, Iorio A. Intracranial haemorrhage in patients on antithrombotics: clinical presentation and determinants of outcome in a prospective multicentric study in Italian emergency departments. Cerebrovasc Dis. 2006;22(4):286-93. Epub 2006 Jul 17. PubMed PMID: 16847397.

  318. 319.Gringeri A, Monzini M, Tagariello G, Scaraggi FA, Mannucci PM, The Emoclot 15 Study Members. Occurrence of inhibitors in previously untreated or minimally treated patients with haemophilia A after exposure to a plasma-derived solvent-detergent factor VIII concentrate. Haemophilia 2006, 12(2):128-32. (Iorio A listed in the Appendix as Emoclot 15 study member).

  319. 320.Mancuso ME, Rumi MG, Santagostino E, Linari S, Coppola A, Mannucci PM, Colombo M, Hepatitis Study Group of the Association of Italian Hemophilia Centers. High efficacy of combined therapy with pegylated interferon plus ribavirin in patients with hemophilia and chronic hepatitis C. Haematologica. 2006, 91: 1367-1371 (Iorio A in the Appendix as member of the study group).

  320. 321.Iorio AM, Camilloni B, Basileo M, Guercini F, Conti S, Ferrante F, Paccamiccio E, Iaboni S, Vecchioli M, Iorio A. Influenza vaccination in patients on long-term anticoagulant therapy. Vaccine. 2006 Nov 10;24(44-46):6624-8. Epub 2006 Jun 8. PubMed PMID: 16828939.

  321. 322.Palareti G, Cosmi B, Legnani C, Tosetto A, Brusi C, Iorio A, Pengo V, Ghirarduzzi A, Pattacini C, Testa S, Lensing AW, Tripodi A, PROLONG Investigators. D-dimer testing to determine the duration of anticoagulation therapy. N Engl J Med. 2006 Oct 26;355(17):1780-9. Erratum in: N Engl J Med. 2006 Dec 28;355(26):2797. PubMed PMID: 17065639.

  322. 323.Iorio A, Agnelli G. Are placebo-controlled trials ethical in areas where current guidelines recommend therapy? No. J Thromb Haemost. 2006 Oct;4(10):2133-6. Epub 2006 Jul 17. PubMed PMID: 16848864.

  323. 324.Stobart K, Iorio A, Wu JK. Clotting factor concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD003429. Review. Update in: Cochrane Database Syst Rev. 2011;9:CD003429. PubMed PMID: 16625581.

  324. 325.Iorio A, Stobart K, Bolton-Maggs P. Can evidence harm? Certainly not hemophilia treatment and community. J Thromb Haemost. 2006 Mar;4(3):505-6. PubMed PMID: 16460430.

  325. 326.Iorio A, Guercini F, Ferrante F, Nenci GG. Safety and efficacy of ximelagatran: meta-analysis of the controlled randomized trials for the prophylaxis or treatment of venous thromboembolism. Curr Pharm Des. 2005;11(30):3893-918. PubMed PMID: 16305520.

  326. 327.Iorio A., Ferrante F. Gestione ed organizzazione di un centro di sorveglianza della terapia anticoagulante. Annali della Facoltà di Medicina e Chirurgia della Università di Perugia che pubblicano gli Atti della Accademia Anatomico-Chirurgica (0365-2270) 2005, vol.96 supp. 1.

  327. 328.Mantovani L., Monzini M., Mannucci P., Scalone L., Villa M., Gringeri A., for the Conan Study Group.Differences between patients’, physicians’ and pharmacists’ preferences for treatment products in haemophilia: a discrete choice experiment. Haemophilia (Oxford. Print). 2005.

  328. 329.Belvini D., Salviato R., Radossi P., Pierobon F., Mori P., Castaldo G., Tagariello G., AICE HB study group. Molecular genotyping of the Italian cohort of patients with hemophilia B. Haematologica (0390-6078) 2005, 90: 635-642. (Iorio A listed as Head of the Centro Emofil di Perugia.).

  329. 330.Mourvaki E, Ferrante F, Ghirarduzzi A, Brini M, Depunzio I, Iorio A. Performance comparison of three assay methods used in fasting and postmethionine load plasma homocysteine determinations from patients with vascular disease. Am J Clin Pathol. 2005 Nov;124(5):675-81. PubMed PMID: 16203288.

  330. 331.Conti S, La Torre D, Gambelunghe G, Ciorba E, Iorio A. Successful treatment with rFVIIa of spontaneous intracerebral hemorrhage in a patient with mechanical prosthetic heart valves. Clin Lab Haematol. 2005 Aug;27(4):283-5. PubMed PMID: 16048499.

  331. 332.Stobart K, Iorio A, Wu JK. Clotting factor concentrates given to prevent bleeding and bleeding-related complications in people with hemophilia A or B. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD003429. Review. Update in: Cochrane Database Syst Rev. 2006;(2):CD003429. PubMed PMID: 15846666.

  332. 333.Iorio A. Prevention of venous thromboembolism after major orthopedic surgery: summing up evidence about old and new antithrombotic agents. J Thromb Haemost. 2004 Jul;2(7):1055-7. Review. Erratum in: J Thromb Haemost. 2004 Aug;2(8):1504. PubMed PMID: 15219186.

  333. 334.Silingardi M, Salvarani C, Boiardi L, Accardo P, Iorio A, Olivieri I, Cantini F, Salvi F, La Corte R, Triolo G, Ciccia F, Ghirarduzzi A, Filippini D, Paolazzi G, Iori I. Factor V Leiden and prothrombin gene G20210A mutations in Italian patients with Behçet’s disease and deep vein thrombosis. Arthritis Rheum. 2004 Apr 15;51(2):177-83. PubMed PMID: 15077257.

  334. 335.Iorio A, Guercini F, Pini M. Low-molecular-weight heparin for the long-term treatment of symptomatic venous thromboembolism: meta-analysis of the randomized comparisons with oral anticoagulants. J Thromb Haemost. 2003 Sep;1(9):1906-13. PubMed PMID: 12941030.

  335. 336.Conti S, Guercini F, Iorio A. Low-molecular-weight heparin and cancer survival: review of the literature and pooled analysis of 1,726 patients treated for at least three months. Pathophysiol Haemost Thromb. 2003 Jul-2004 Aug;33(4):197-201. PubMed PMID: 15583449.

  336. 337.Iorio A. Applied pharmacoeconomics: considerations to drive the choice of a prophylactic antithrombotic regimen. J Thromb Haemost. 2003 May;1(5):881-3. Review. PubMed PMID: 12871350.

  337. 338.Testa S., Iorio A., Alatri A., Parisoli A., Ghirarduzzi A., Berrettini M., Rinaldi G., per il Gruppo di Studio di Centri aderenti all’FCSA e per il Gruppo di Studio Coagulazione della SIMEL. Gli standard di accreditamento dei centri per la sorveglianza dei pazienti in terapia anticoagulante orale (TAO). Journal of Laboratory Medicine 2002 3 (2-s1): 52-56.

  338. 339.Nicolini A, Ghirarduzzi A, Iorio A, Silingardi M, Malferrari G, Baldi G. Intracranial bleeding: epidemiology and relationships with antithrombotic treatment in 241 cerebral hemorrhages in Reggio Emilia. Haematologica. 2002 Sep;87(9):948-56. PubMed PMID: 12217807.

  339. 340.Goracci S, Filippucci E, Guercini F, Santucci L, Iorio A. Successful treatment of Dieulafoy’s disease in a von Willebrand patient. Haematologica. 2002 Jul;87(7):ECR23. PubMed PMID: 12091139.

  340. 341.Iorio A., Agnelli G. Heparin reduces venous thromboembolism in neurosurgery but increases the risk of bleeding. (Iorio A, Agnelli G. Low molecular weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a metanalysis. Arch Intern Med. 2000;160:2327-2332). ACP journal club (1056-8751) 2001: 55.

  341. 342.Tripodi A., Chantarangkul V., Lombardi R., Lecchi A., Mannucci P., Cattaneo M., for the ad hoc study group.Multicenter study of homocysteine measurement – performance characteristic of different methods, influence of standards on interlaboratory agreement results. Thrombosis and Haemostasis (0340-6245) 2001, 85: 291-5, (Iorio A. listed as author in the ad hoc study group) (IF = 3,723).

  342. 343.Agnelli G, Prandoni P, Santamaria MG, Bagatella P, Iorio A, Bazzan M, Moia M, Guazzaloca G, Bertoldi A, Tomasi C, Scannapieco G, Ageno W; Warfarin Optimal Duration Italian Trial Investigators. Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators. N Engl J Med. 2001 Jul 19;345(3):165-9. PubMed PMID: 11463010.

  343. 344.Silingardi M, Ghirarduzzi A, Galimberti D, Iorio A, Iori I. Mesenteric-portal vein thrombosis in a patient with hyperhomocysteinemia and heterozygous for 20210A prothrombin allele. Thromb Haemost. 2000 Aug;84(2):358-9. PubMed PMID: 10959718.

  344. 345.Iorio A, Agnelli G. Low-molecular-weight and unfractionated heparin for prevention of venous thromboembolism in neurosurgery: a meta-analysis. Arch Intern Med. 2000 Aug 14-28;160(15):2327-32. PubMed PMID: 10927730.

  345. 346.Silingardi M, Ghirarduzzi A, Tincani E, Iorio A, Iori I. Miconazole oral gel potentiates warfarin anticoagulant activity. Thromb Haemost. 2000 May;83(5):794-5. Review. PubMed PMID: 10823285.

  346. 347.Buratta S, Andreoli V, Mambrini R, Iorio A, Porcellati S, Mozzi R. Serine base exchange enzyme in porcine lyophilised platelets: enzyme properties and modulation by AlF4- and different types of heparin. Mol Cell Biochem. 2000 Jan;203(1-2):177-84. PubMed PMID: 10724347.

  347. 348.Ascani A, Iorio A, Agnelli G. Withdrawal of warfarin after deep vein thrombosis: effects of a low fixed dose on rebound thrombin generation. Blood Coagul Fibrinolysis. 1999 Jul;10(5):291-5. PubMed PMID: 10456621.

  348. 349.M. D’Inca, A. Ghirarduzzi, I. Iori, A. Iorio, G. Rinaldi, C. Salvarani, M. Silingardi. Sindrome da anticorpi antifosfolipidi. L’internista ospedaliero 1998;3:12-22.

  349. 350.G. Agnelli, A. Iorio. Enoxaparin in Neurosurgical patients. N Eng J Med 1998, 339: 1639-40. (IF = 28,660).

  350. 351.Cattabiani ML, Dallari A, Gaddi O, Giovanardi F, Troiso A, Guidetti D, Iorio A, Lo G, Manzini L, Baldi G, Parmiggiani G, Procicchiani D, Tincani E, Iori I. Indicazioni al trattamento dell’ictus ischemico. Geriatria 1998;4(suppl):21-28.

  351. 352.Agnelli G, Piovella F, Buoncristiani P, Severi P, Pini M, D’Angelo A, Beltrametti C, Damiani M, Andrioli GC, Pugliese R, Iorio A, Brambilla G. Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med. 1998 Jul 9;339(2):80-5. PubMed PMID: 9654538.

  352. 353.Alatri A, Iorio A, Agnelli G. Choice of end-points in assessing the efficacy of post-discharge prophylaxis for venous thromboembolism. Thromb Haemost. 1998 Jan;79(1):234. PubMed PMID: 9459353.

  353. 354.Agnelli G, Iorio A, Parise P, Goldhaber SZ, Levine MN. Fibrinogenolysis and thrombin generation after reduced dose bolus or conventional rt-PA for pulmonary embolism. The Coagulation Project Investigators of the Bolus Alteplase Pulmonary Embolism Group. Blood Coagul Fibrinolysis. 1997 Jun;8(4):216-22. PubMed PMID: 9199818.

  354. 355.Iorio A, Nucciarelli F, Renga C, Nenci GG, Gianese F, Agnelli G. Effect of dermatan sulphate on activated partial thromboplastin time determined with different reagents. Haemostasis. 1997 Mar-Apr;27(2):85-90. PubMed PMID: 9212356.

  355. 356.Mozzi R, Andreoli V, Buratta S, Iorio A. Different mechanisms regulate phosphatidylserine synthesis in rat cerebral cortex. Mol Cell Biochem. 1997 Mar;168(1-2):41-9. PubMed PMID: 9062892.

  356. 357.Iorio A, Agnelli G. Pharmacokinetic optimisation of the treatment of deep vein thrombosis. Clin Pharmacokinet. 1997 Feb;32(2):145-72. Review. PubMed PMID: 9068929.

  357. 358.Ricotta S, Iorio A, Parise P, Nenci GG, Agnelli G. Post discharge clinically overt venous thromboembolism in orthopaedic surgery patients with negative venography-an overview analysis. Thromb Haemost. 1996 Dec;76(6):887-92. Review. PubMed PMID: 8972006.

  358. 359.Ricotta S, Iorio A, Parise P, Nenci GG, Agnelli G. Post discharge clinically overt venous thromboembolism in orthopaedic surgery patients with negative venography - an overview analysis. Thromb Haemost 1996;76:887-92.

  359. 360.Agnelli G, Iorio A, Ricotta S, Parise P, Nenci GG. Post-discharge deep-vein thrombosis after orthopaedic surgery. Lancet. 1996 Oct 26;348:1179-1180. PubMed PMID: 8888208.

  360. 361.Berrettini M, Parise P, Ricotta S, Iorio A, Peirone C, Nenci GG. Increased plasma levels of tissue factor pathway inhibitor (TFPI) after n-3 polyunsaturated fatty acids supplementation in patients with chronic atherosclerotic disease. Thromb Haemost. 1996 Mar;75(3):395-400. PubMed PMID: 8701396.

  361. 362.Muscat C, Bertotto A, Ercolani R, Bistoni O, Agea E, Cesarotti M, Fiorucci G, Spinozzi F, Gerli R. Long term treatment of rheumatoid arthritis with high doses of intravenous immunoglobulins: effects on disease activity and serum cytokines. Annals of Rheumatic Diseases. 1995;5:382-85 (Iorio A. did statistical analysis, as stated in the acknowledgements).

  362. 363.Agnelli G, Iorio A, Renga C, Boschetti E, Nenci GG, Ofosu FA, Hirsh J. Prolonged antithrombin activity of low-molecular-weight heparins. Clinical implications for the treatment of thromboembolic diseases. Circulation. 1995 Nov 15;92(10):2819-24. PubMed PMID: 7586247.

  363. 364.Parise P, Hauert J, Iorio A, Callegari P, Agnelli G. Streptokinase and rt-PA activate platelets by a different way: implications on the rethrombosis rate after their administration in myocardial infarction. J Lab Clin Med. 1995 Feb;125(2):212-21. PubMed PMID: 7531212.

  364. 365.Iorio A, Alatri A, Mazzolai L, Agnelli G. Plasma thrombin neutralization assay: pharmacokinetic applications. Semin Thromb Hemost. 1994;20(3):266-73. PubMed PMID: 7824961.

  365. 366.Agnelli G, Iorio A, de Angelis V, Nenci GG. Dermatan sulphate in heparin-induced thrombocytopenia. Lancet. 1994 Nov 5;344(8932):1295-6. PubMed PMID: 7968002.

  366. 367.Parise P, Hauert J, Iorio A, Callegari P, Nenci GG. Fibrinogen degradation products generation is the major determinant of platelet inhibition induced by plasminogen activators in platelet rich plasma. Fibrinolysis 1993; 7, 379-385. (IF = 0,845)
  367. Paglicci Reattelli L, Lalli L, Iorio A. La valutazione dell’idoneità allo sport agonistico nella casistica dei Servizi di Medicina Sportiva delle U.S.L. e della Commissione d’Appello della Regione Umbria. (1982-1990). Medicina Legale - Quaderni Camerti 1992, XIV(2), 199-213.

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