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Stefano Iotti

Full Professor

Department of Pharmacy and Biotechnology

Academic discipline: BIOS-09/A Clinical Biochemistry and Clinical Molecular Biology

Director of Second Cycle Degree in Health Biology

Publications

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Publications prior to 2004

Iotti S, Colonna FP, Garbesi AM, Spadari S, Focher F, Ciarrocchi G, Arcamone F. L-2'-desossiuridine e composizioni farmaceutiche che le contengono. Brevetto Italiano per Invenzione Industriale N° 22032A/90. Novembre 1990.

 Capobianco ML, Colonna FP, Forni A, Garbesi A, Iotti S, Moretti I, Samori B, Tondelli L. Interactions of nucleic acids with distamycins. Binding of Dst-3 to d(CGTTTAAACG)2 and d(CGTACGTACG)2. Nucleic Acids Research, 1991; 19:1695-1698.

Iotti S, Funicello R, Zaniol P, Barbiroli B. Kinetics of post-exercise phosphate transport in human skeletal muscle: an in vivo 31P-MR spectroscopy study. Biochemical and Biophysical Research Communications 1991; 176:1204-1209.

Iotti S, Funicello R, Zaniol P, Barbiroli B. The rate of phosphate transport during recovery from muscular exercise depends on cytosolic [H+]. A 31P-NMR spectroscopy study in humans. Biochemical and Biophysical Research Communications 1991; 178:871-877.

Spadari S, Maga G, Focher F, Ciarrocchi G, Manservigi R, Arcamone F, Capobianco M, Carcuro A, Colonna F, Iotti S, Garbesi A. L-Thymidine is phosphorylated by herpes simplex virus type 1 Thymidine kinase and inhibits viral growth. Journal of Medicinal Chemistry, 1992; 35:4214-4220.

 Barbiroli B, Funicello R, Iotti S, Montagna P, Ferlini A, Zaniol P. 31P-NMR spectroscopy of skeletal muscle in Becker dystrophy and DMD/BMD carriers. Altered rate of phosphate transport. Journal of the Neurological Sciences 1992; 109:188-195.

Barbiroli B, Montagna P, Cortelli P, Funicello R, Iotti S, Monari L, Pierangeli G, Zaniol P, Lugaresi E. Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy. in patients affected by migraine with aura. Neurology 1992; 42:1209-1214.

 Barbiroli B, Montagna P, Martinelli P, Lodi R, Iotti S, Cortelli P, Funicello R, Zaniol P. Defective brain energy metabolism shown by in vivo 31P MR spectroscopy in 28 patients with mitochondrial cytopathies. Journal of Cerebral Blood Flow and Metabolism 1993; 13:469-474.

Iotti S, Lodi R, Frassineti C, Zaniol P, Barbiroli B. In vivo assessment of mitochondrial functionality in human gastrocnemius muscle by 31P MRS. The role of pH in the evaluation of phosphocreatine and inorganic phosphate recoveries from exercise. NMR in Biomedicine 1993; 6:248-253.

Barbiroli B, McCully K K, Iotti S, Lodi R, Zaniol P, Chance B. Further impairment of muscle phosphate kinetics by lengthening exercise in DMD/BMD carriers. An in vivo 31P NMR spectroscopy study. Journal of the Neurological Sciences 1993; 119:65-73.

Montagna P, Cortelli P, Monari L, Pierangeli G, Parchi P, Lodi R, Iotti S, Frassineti C, Zaniol P, Lugaresi E, Barbiroli B. 31P-magnetic resonance spectroscopy in migraine without aura. Neurology 1994; 44:666-669.

McCully KK, Iotti S, Kendrick K, Wang Z, Posner JD, Leigh JS Jr, Chance B. Simultaneous in vivo measurements of oxygen saturation and PCr kinetics following exercise in normal humans. Journal of Applied Physiology. 1994; 77:5-10.

Lodi R., S. Iotti, L. Scorolli, Lg Scorolli, A.M. Bargossi, C. Sprovieri, P. Zaniol, R. Meduri, B. Barbiroli. The use of Phosphorus magnetic resonance spectroscopy to study in vivo the effect of coenzyme Q treatment in retinitis pigmentosa Molecular Aspects of Medicine 1994; 15:s221-s230.

Barbiroli B., S. Iotti, R. Lodi. Spettroscopia RMN del fosforo nello studio del metabolismo delle neoplasie intracraniche primitive. Rivista di Neuroradiologia 1994; 7:145-150.

Iotti S., R.Lodi, B. Barbiroli. Spettroscopia di risonanza magnetica del fosforo: valutazione non invasiva in vivo della funzionalità mitocondriale del muscolo scheletrico e del cervello. Microscopia Elettronica 1994; 15:67-78.

Lodi R., P. Montagna, S. Iotti, P. Zaniol, P. Barboni, P. Puddu, B. Barbiroli. Brain and muscle energy metabolism studied in vivo by 31P-magnetic resonance spectroscopy in NARP syndrome. Journal of Neurology Neurosurgery and Psychiatry 1994; 57:1492-1496.

Toscano A, Fazio CM, Vita G, Cannavo S, Bresolin N, Bet L, Prelle A, Barbiroli B, Iotti S, Zaniol P, Magaudda A, Trimarchi F, Massina C. Early onset cerebellar ataxia, myoclonus and hypogonadism in a case of mitochondrila complex III deficiency treated with vitamins K3 and C. Journal of Neurology, 1995; 242:203-209.

Uncini A, Lodi R, Di Muzio A, Silvestri G, Servidei S, Lugaresi A, Iotti S, Zaniol P, Barbiroli B. Abnormal brain and muscle energy metabolism shown by 31P-MRS in familial hemiplegic migraine. Journal of the Neurological Sciences; 1995; 129:214-222.

Barbiroli B, Montagna P, Cortelli P, Iotti S, Lodi R, Barboni P, Monari L, Lugaresi E, Frassineti C, Zaniol P. Defective brain and muscle energy metabolism shown by in vivo 31P magnetic resonance spectroscopy in non-affected carriers of 11778 mtDNA mutation. Neurology; 1995; 45:1364-1369.

Barbiroli B., Medori R., Tritschler H.J., Klopstock T., Seibel P., Reichmann H., Iotti S., Lodi R., Zaniol P. Lipoic (Thioctic) acid increases brain energy availability and skeletal muscle performance as shown by in vivo 31P MRS in a patient with mitochondrial cytopathy. Journal of Neurology, 1995; 242:472-477.

Barbiroli B., Lodi R., Iotti S. Phosphorus MR spectroscopy of human brain. An overview after several years experience studying some 1.200 patients. In: Podo F, Bovee WMMI, de Certains JD, Henriksen O, Leach MO, Leibfritz D Eds. Roma Istituto Superiore Sanità Eurospin Annual 1995-1996; 385-396.

Martinelli P, Giuliani S, Lodi R, Iotti S, Zaniol P, Barbiroli B. Failure of brain and skeletal muscle energy metabolism in multiple system atrophy shown by in vivo phosphorus MR spectroscopy. Advances in Neurology,1996; 69:271-277.

Iotti S, Frassineti C, Alderighi L, Sabatini A, Vacca A, Barbiroli B. In vivo assessment of free magnesium concentration in human brain by 31P MRS. A new calibration curve based on a mathematical algorithm. NMR in Biomedicine 1996; 9 24-32.

McCully KK, Natelson BH, Iotti S, Sisto SA, Leigh JS Jr. Reduced oxidative muscle metabolism in chronic fatigue syndrome. Muscle & Nerve 1996; 19: 621-625.

Frassineti C., Iotti S., Lodi R., Zaniol P., Barbiroli B. Effect of oral phosphocreatinine on human skeletal muscle shown by in vivo 31P-NMR In vivo 1996; 10:429-434.

Barbiroli B., Medori R., Tritschler H.J. Iotti S., Lodi R., Zaniol P. Thioctic acid stimulates muscle ATP production in patients with type 2 diabetes and diabetic polyneuropathy. An in vivo phosphorus magnetic resonance spectroscopy study. Diabetes und Stoffwechsel. 1996; 5 (suppl. 3): 71-76

Iotti S., Lodi R., Gottardi G., Zaniol P., Barbiroli B. Inorganic phosphate is transported into mitochondria in the absence of ATP biosynthesis. An in vivo 31p nmr study in the human skeletal muscle. Biochemical and Biophysical Research Communications 1996; 225: 191-194.

Barbiroli B., Lodi R., Iotti S. Spettroscopia NMR del fosforo: metodo non invasivo per lo studio in vivo delle malattie metaboliche. Atti dell’Accademia Lancisiana Roma 1996; XL (1): 47-50

Montagna P., Lodi R., Cortelli P. Pierangeli G., Iotti S., Cevoli S., Zaniol P., Barbiroli B. Phosphorus magnetic resonance spectroscopy in cluster headache. Neurology, 1997; 48:113-118.

Lodi R., Kemp G.J., Montagna P., Pierangeli G., Cortelli P., Iotti S., Radda G.K., Barbiroli B. Quantitative analysis of skeletal muscle mitochondrial function and proton efflux in migraine and cluster headache. Journal of the Neurological Sciences 1997; 146: 73-80.

Cortelli P, Montagna P, Pierangeli G, Lodi R, Barboni P, Liguori R, Carelli V, Iotti S, Zaniol P, Lugaresi E, Barbiroli B. Clinical and brain bioenergetics improvement with idebenone in a patient with Leber's hereditary optic neuropathy. A clinical and 31P-MRS study. Journal of the Neurological Sciences 1997; 148: 25-31.

Lodi R., Iotti S., Barbiroli B. Studio in vivo nell'uomo del metabolismo muscolare e cerebrale con spettroscopia a RM del fosforo utilizzando magneti a bassa risoluzione. In: Spettroscopia di risonanza magnetica nucleare in biomedicina. Luciani A.M., Rosi A. Rapporti ISTISAN 97/40 1997.

Barbiroli B., Iotti S., Lodi R. In vivo assessment of human skeletal muscle mitochondria respiration in health and disease. Mol. Cell. Biochem. 1997; 174:11-15.

Lodi R., R. Rinaldi, A. Gaddi, S. Iotti, R. D’Alessandro, N. Scoz, M. Battino, V. Carelli, G. Azzimondi, P. Zaniol, B. Barbiroli. Brain and skeletal muscle bioenergetic failure in familial hypobetalipopreteinemia. Journal of Neurology Neurosurgery and Psychiatry 1997; 62:574-580.

Salerno C., S. Iotti, R. Lodi, C. Crifò, B. Barbiroli. Failure of muscle energy metabolism in a patient with adenylosuccinate lyase deficiency: an in vivo study by phosphorus NMR spectroscopy. Biochimica Biophysica Acta 1997; 1360: 271-276.

Lodi R., G.J. Kemp, S. Iotti, G.K. Radda, B. Barbiroli. Influence of cytosolic pH on in vivo assessment of human muscle mitochondrial respiration by 31P-MRS MAGMA 1997; 5:165-171.

Tritschler H.J., Barbiroli B., Medori R., Iotti S., Lodi R., Zaniol P. Thioctic acid stimulates muscle ATP production in patients with type 2 diabetes and diabetic polyneuropathy. In: Lipoic Acid in Health and Disease; Fuchs J., Packer L., Zimmer G., Eds. Marcel Dekker, New York 1997.

Lodi R., Montagna P., Soriani S., Iotti S., Arnaldi C., Cortelli P., Pieraqngeli G., Patuelli A., Zaniol P., Barbiroli B. Deficit of brain and skeletal muscle bioenergetics and low brain magnesium in juvenile migraine. An in vivo 31P-MR spectroscopy interictal study. Pediatric Research 1997; 42:866-871.

Barbiroli B, Salardi S, Iotti S, Lodi R, Zucchini S, Zaniol P, Cacciari E. Defective muscle energy metabolism and ion transport revealed by phosphorus magnetic resonance spectroscopy in patients with insulin-dependent diabetes mellitus. Medical Biochem. 1998; 1:83-92.

Barbiroli B., Frassineti C., Martinelli P., Iotti S., Lodi R., Cortelli P., Montagna P. Coenzyme Q improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorus magnetic resonance spectroscopy. Cellular and Molecular Biology 1997; 43:(5) 741-749.

Barbiroli B., Iotti S. Lodi R. Magnetic resonance spectroscopy of skeletal muscle. Non invasive in vivo biochemical characterization of neurological disorders. World Health Organization Pubblication 1998; pp 74-87.

Salerno C, Iotti S, Lodi R, Crifo C, Barbiroli B. Muscle energy metabolism in human adenylosuccinase deficiency. An in vivo 31P-NMR spectroscopy study. Adv Exp Med Biol. 1998; 431: 275-278.

 B Barbiroli, S Iotti, R Lodi. Aspects of human bioenergetics as studied in vivo by magnetic resonance spectroscopy Biochimie 1998; 80:847-53.

Bruno Barbiroli, Stefano Iotti, Pietro Cortelli, Paolo Martinelli, Raffaele Lodi, Valerio Carelli,Pasquale Montagna. Low brain intracellular free magnesium in mitochondrial cytopathies. J. Cerebr. Blood Flow Metab. 1999; 19(5):528-32.

Bruno Barbiroli, Paolo Martinelli, Alberto Patuelli, Raffaele Lodi, Stefano Iotti, Pietro Cortelli, Pasquale Montagna. Phosphorus Magnetic Resonance Spectroscopy in Multiple System Atrophy and Parkinson’s Disease. Movement Disorders 1999; 14(3):430-5.

B. Barbiroli, S. Iotti, R. Lodi. Improved brain and muscle mitochondrial respiration with CoQ. An in vivo study by 31P-MR spectroscopy in patients with mitochondrial cytopathies. BioFactor 1999; 9(2-4):253-60.

Lodi R, Montagna P, Cortelli P, Iotti S, Cevoli S, Carelli V, Barbiroli B. Effect of "Secondary" Leber's Hereditary Optic Neuropathy Mitochondrial DNA Mutations on Brain and Muscle Oxidative Metabolism. An in vivo 31P Magnetic Resonance Spectroscopy Study" Neurology 1999; 52 A230-A230.

S. Iotti, C. Frassineti, L. Alderighi, A. Sabatini, A. Vacca and B. Barbiroli. 'In Vivo 31P-MRS assessment of cytosolic [Mg2+] in the human skeletal muscle in different metabolic condition. Magetic Resonance Imaging 2000; 18:607-614.

Martinelli P, Scaglione C, Lodi R, Iotti S, Barbiroli B. Deficit of brain and skeletal muscle bioenergetics in progressive supranuclear palsy shown in vivo by phosphorus MR spectroscopy. Movement Disorders 2000; 15(5):889-893.

Lodi R, Montagna P, Cortelli P, Iotti S, Cevoli S, Carelli V, Barbiroli B. "Secondary" 4216/ND1 and 13708/ND5 Leber's Hereditary Optic Neuropathy mtDNA mutations do not further impair mitochondrial oxidative metabolism deficit due to 11778/ND4 mtDNA mutation. An in vivo brain and skeletal muscle phosphorus MR spectroscopy study. Brain 2000; 123:1896-1902.

Lodi R, Iotti S, Cortelli P, Pierangeli G, Cevoli S, Clementi V, Soriani S, Montagna P, Barbiroli B. Deficient energy metabolism is associated with low free magnesium in the brains of patients with migraine and cluster headache. Brain Research Bulletin 2001; 4:437-441.

 Lodi R, Stracciari A, Iotti S, Donati S, Guarino M, Clementi V, Bolondi L, Barbiroli B. Water apparent diffusion coefficient is increased in the brains of cirrhotic patients. Neurology 2001; 56 04.023-04.023.

Lodi R, Carelli V, Cortelli P, Iotti S, Valentino ML, Barboni P, Pallotti F, Montagna P, Barbiroli B. Phosphorus MR spectroscopy shows a tissue specific in vivo distribution of biochemical expression of the G3460A mutation in Leber's hereditary optic neuropathy.
J Neurol Neurosurg Psychiatry. 2002; 72:805-807.

Cecconi F, Frassineti C, Gans P, Iotti S, Midollini S, Sabatini A, Vacca A. Complex formation equilibria of phosphocreatine with sodium, potassium and magnesium ions. Polyhedron 2002; 21: 1481-1484.

Barbiroli B, Lodi R, Iotti S, Clementi V. Alterazioni del metabolismo cerebrale in pazienti con insufficienza epatica avviati al trapianto di fegato: studio in vivo con la spettroscopia di risonanza magnetica (MRS). In: “Clinica e Biologia delle gravi insufficienze d’organo” Bologna: CLUEB 2002.

Barbiroli B, Gaiani S, Lodi R, Iotti S, Tonon C, Clementi V, Donati G, Bolondi L [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12372552&dopt=Abstract] . Abnormal brain energy metabolism shown by in vivo phosphorus magnetic resonance spectroscopy in patients with chronic liver disease. Brain Res Bull. 2002; 59:75.

Frassineti C and Iotti S. Chemical speciation and determination of equilibrium constants in complex system (Review). Recent Research Developments in Analytical Biochemistry 2002; 2:107-134.

Lodi R, Stracciari A, Tonon C, Weiger M, Iotti S, Donati G, Guarino M, Bolondi L, Barbiroli B..Brain diffusion weighted MRI in cirrhosis In: Encephalopathy and Nitrogen Metabolism in liver failure. Jones EA, Meijer AJ and Chamuleau RAFM Eds. Kluwer Academic Publishers, Dordrecht, The Netherlands, 2003, 237-249