Foto del docente

Sandra Cristino

Assistant professor

Department of Biological, Geological, and Environmental Sciences

Academic discipline: MED/42 Hygiene and Public Health


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Publications prior to 2004

  • Lisignoli G., Toneguzzi S., Grassi F., Piacentini A., Tschon M., Cristino S., Gualtieri G., Facchini A.: Different chemokines are expressed in human arthritic bone biopsies: IFNg and IL6 differently modulate IL8, MCP-1 and RANTES production by arthritic osteoblasts. Cytokine 2002, 20: 231-238I.F. 2.183.
  • Roseti L., Gigolo B., Lisignoli G., De Franceschi L., Cristino S., Grassi F., Fini M., Giardino R., Facchini A. Repair of cartilage and bone defects by the use of autologous cells grown onto a hyaluronan-derivative scaffold. Bioceramics Surfaces behaviour in vitro and in vivo, 2002 (356-364) Edited by A.Ravaglioli and A. Krajewski.
  • Lisignoli G., Toneguzzi S., Piacentini A., Cattini L., Lenti A., Tschon M., Cristino S., Grassi F., Facchini A.: Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release. Journal of Cellular Physiology 2003, 194:71-79.I.F. 5.46.
  • Lisignoli G., Toneguzzi S., Zini N., Piacentini A., Cristino S., Tschon M., Grassi F., Giardino R., Facchini A.: Hyaluronan-based biomaterial (HYAFF 11) as scaffold to support mineralization of bone marrow stromal cells; Chirurgia degli organi di movimento 2003,Ottobre-Dicembre 2003 Vol. LXXXVIII, Fasc.4.
  • ▪Lisignoli G.,Piacentini A., Toneguzzi S., Grassi F., Tschon M., Cristino S.,Facchini A.,Mariani E.: Age-associated changes in functional response toCXCR3 and CXCR5 chemokine receptors in human osteoblast; Biogerontology 2003, 4:309-317. I.F. 2.108.
  • ▪Grassi F. Piacentini A; Cristino S., Toneguzzi S., Cavallo C., Facchini A., Lisignoli G.:Human osteoclasts express different CXC chemokines depending on cell culture substrate: molecular and immunocytochemical evidence of high levels of CXCL10 and CXCL12 [] . Histochem Cell Biol. 2003 Nov;120(5):391-400.
  • ▪Rotini R., Errani C., Minarelli A., Cristino S.: Storia naturale dell'atrosi primitiva gleno-omerale. Artropapie della Spalla - Chirurgia e Riabilitazione 20-22 Marzo 2003 Roma.
  • ▪Grassi F., Piacentini A., Cristino S., Toneguzzi S. ,Cavallo C., Facchini A., Lisignoli G. Human osteoclasts express different CXC chemokines depending on cell culture substrate: molecular and immunocytochemical evidence of high levels of CXCL10 and CXCl12. Histochemestry and Cellular Biology 2003,120: 391-400. I.F. 2.581.
  • Lisignoli G., Cristino S., Toneguzzi S., Grassi F. , Piacentini A., Cavallo C., Facchini A., Mariani E: IL1b andTNFa differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from Osteoartrhitis patients: evidence of changes associated to cell maturation. Experimental Gerontology 2004, 39:659-665.I.F. 2.857.
  • Grassi F., Cristino S., Toneguzzi S., Piacentini A., Facchini A., Lisignoli G.: CXCL12 chemokine up-regulates bone resorption and MMP-9 relase by human osteoclasts: CXCL12 levels are increased in synovial and bone tissue of rheumatoid artrhritis patients. Journal of Cellular Physiology 2004, 199:244-251. I.F. 5.463.
  • Lisignoli G., Toneguzzi S., Piacentini A., Cristino S., Cattini L., Grassi F., Facchini A. Recruitment and proliferation of T Lymphocytes is supported by activated human osteoblasts: involvement of CD54 (ICAM-1) and CD106 (VCAM-1) adhesion molecules and CXCR3 chemokine receptor. Journal of Cellular Physiology 2004, 198:388-398.I.F. 5.463.
  • Grassi F., Piacentini A.,Cristino S., Toneguzzi S., Facchini A., Lisignoli G. : Inhibition of CD95 apoptotic signaling by interferon-γin human chondrocytes is associated with increased expression of FLICE inhibitory protein. Arthritis and Rheumatism 2004, 50:498-506. I.F. 7.190.
  • Roseti L., Gigolo B., De Franceschi L., Lisignoli G., Cristino S., Maltarello M.C., Frizziero A., Facchini A., : Ceramics and gene therapy. Materials for Tissues Engineering 2004 (433-437) Edited by A.Ravaglioli and A. Krajewski.
  • Cristino S., Grassi F., Toneguzzi S., Piacentini A., Gigolo B., Santi S., Riccio M.,Tognana E., Facchini A., Lisignoli G.: Analysis of mesenchymal stem cells grown on a three-dimensional HYAFF 11Ò- based prototype ligament scaffold. Journal of Biomedical Materials Research, Part A 2005, 275-283. I.F.2.397.
  • ▪Zini N., Lisignoli G., Solimando L., Bavelloni A., Valmori A., Cristino S., Martelli A.M., Faccini A., Maraldi N.M.: Quantitative immonodetection ofkey elementsof polyphosphoinositide signal trasduction in osteoblasts from arthritic patients shows a direct correlation with cell proliferation. Histochemestry and Cell Biology, Biol. 2005 Aug;124 (2):131-7. I.F. 2.581.
  • Lisignoli G., Cristino S., Piacentini A., Toneguzzi S., Grassi F., Cavallo C., Zini N., Solimando L., Maraldi M. N., Facchini A.: Cellular and molecular events during chondrogenesis of human mesenchymal stromal cells grown in a three-dimensional hyaluronan based scaffold. Biomaterilas, 26(2005) 5677-5686. I.F.2.903.
  • Leoni E., Zanetti F., Cristino S., Legnani PP.: Monitoring and control of opportunistic bacteria in a spa water used for aerosol hydrotherapy. Ann Ig. 2005 Sep-Oct;17(5):377-84.
  • Lisignoli G., Toneguzzi S., Piacentini A., Cristino S., Grassi F., Cavallo C., Facchini A.: CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients. Journal of Cellular Physiology 2006: 206 (1):78-85 .I.F. 5.463.
  • Lisignoli G. Cristino S., Piacentini A., Zini N., Noel D., Jorgensen C, Facchini A.: Chondrogenic differentiation of murine and human mesenchymal stromal cells in a hyaluronic acid scaffold: Differences in gene expression and cell morphology. J Biomed Mater Res A. 2006 Feb 15; . I.F. 2.497.
  • Lisignoli G. Cristino S., Piacentini A., Cavallo C., Caplan AI., Facchini A. : Hyaluronan-based polymer scaffold modulates the expression of inflammatory and degradative factors in mesenchymal stem cells: Involvement of Cd44 and Cd54. J Cell Physiol. 2006 May;207(2):364-73. I.F. 5.463.
  • Facchini A., Lisignoli G., Cristino S., Roseti L., De Franceschi L.,Marconi E., Grigolo B. Human chondrocytes and mesenchymal stem cells grown onto engineered scaffold. Biorheology. 2006;43(3-4):471-80. IF 2.651.
  • Lisignoli G., Piacentini A., Cristino S., Grassi F., Cavallo C., Cattini L., Tonnarelli B., Manferdini C., Facchini A. (2007). CCL20 chemokine induces both osteoblast proliferation and osteoclast differentiation: increased levels of CCL20 are expressed in subchondral bone tissue of rheumatoid arthritis patients. Journal of Cellular Phisiolophy 2007 vol. 210 (3), pp. 798 - 806. IF 3.368.
  • Cristino S., Piacentini A, Manferdini C., Codeluppi K., Grassi F., Facchini A., Lisignoli G. Expression of CXC Chemokines and Their Receptors Is Modulated During Chondrogenic Differentiation of Human Mesenchymal Stem Cells Grown in Three-Dimensional Scaffold: Evidence in Native Cartilage. Tissue Eng Part A. 2008 Jan;14(1):97-105.

    ▪Stok K, Lisignoli G. Cristino S.,, Facchini A.Müller R. Mechano-functional assessment of human mesenchymal stem cells grown in three-dimensional hyaluronan-based scaffold for cartilage tissue engineering. Accept 26Febbraio 2009 - Journal of Biomedical Materials Research: Part. 2010 Apr; 93(1):37-45. Stok KS, Lisignoli G, Cristino S, Facchini A, Müller R.

    ▪Bargellini A., Marchesi I., Leoni E., Mansi A., Cristino S., Marcelloni A.M. , Borella P.. Inter-laboratory validation of a rapid assay for the detection and quantification of Legionella spp. in water samples. Lett Appl Microbiol. 2010 Oct;51(4):421-7.

    ▪Orsini M, Cristino S., Grottola A, Romano-Spica V. Bacteria misagglutination in Legionella surveillance programmes. J Hosp Infect. 2011 Oct;79(2):179-80.

    ▪Cristino S. , Legnani PP, Leoni E. Plan for the control of Legionella infections in long-term care facilities: Role of environmental monitoring. Int J Hyg Environ Health. 2011 Sep 16.

    ▪Checchi, V.,Montevecchi, M.,Legnani, P.,Cristino, S.,Violante, F.,Checchi, L. Rules for managing a dental practice: Waste disposal, disinfection, and sterilization[Le regole di gestione dello studio odontoiatrico: Smaltimento dei rifiuti, disinfezione e sterilizzazione], 2012 Dental Cadmos, 80 (4), pp 184-202.

    ▪D'Addato S., Cicero AF., Rosticci M., Reggi A., Cristino S., Dormi A., Borghi C. Serum Proinflammatory Chemokines in Healthy Elderly Taking or not Taking Simvastatin - Data from the Brisighella Heart Study. Adv Clin Exp Med. 2014 Sep-Oct;23(5):723-8.

    ▪Mancini B, Scurti M, Dormi A, Grottola A, Zanotti A, Cristino S.: Effect of Monochloramine Treatment on Colonization of a Hospital Water Distribution System by Legionella spp.: A 1 Year Experience Study. Environ Sci Technol. 2015, Apr 49, 4551-4558.

  • Bergamaschi A. Zanetti F. Cristino S. Leoni E.: Learning preventive medicine and hygiene in higher education. The experience in a faculty of exercise and sport sciences. Italian Journal of Sport Sciences 2008, 1:48-52.