Areas of particular interest and expertise:
-Prion diseases
-Neurodegenerative diseases, in particular genetic aspects of movement disorders and dementia associated neurodegenerative diseases.
1) Definition of the full spectrum of clinico-pathological phenotypes in human prion disease focusing on the identification and characterization of novel rare phenotypes
2) Study of genetic risk factors in genetic Creutzfeldt-Jakob disease
3) Study of the molecular basis of strain variation in human prion disease through the characterization of the physico-chemical properties of PrPSc.
4) Study of genetic risk factors either causative or phenotype modifying in neurodegenerative diseases. Definition and validation of new diagnostic protocols for the differential diagnosis of neurodegenerative diseases.
5) Analysis of genetic expression in Autosomal Dominant Adult onset Leukodystrophy, ADLD.
